Circulating branch chain amino acids and improvement in liver fat content in response to exercise interventions in NAFLD

Abstract Nonalcoholic fatty liver disease is likely to be associated with increased circulating branched-chain amino acids. We investigated the relationship between changes in branched-chain amino acids levels in the serum and improvement in liver fat content caused by exercise intervention in indiv...

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Autores principales:	Xiulin Shi, Hongyan Yin, Jia Li, Caoxin Huang, Yinling Chen, Zheng Chen, Wei Liu, Weijuan Su, Yiping Zhang, Mingzhu Lin, Yan Zhao, Xuejun Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d126c1939f174743937c4edb8b6673b6
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spelling	oai:doaj.org-article:d126c1939f174743937c4edb8b6673b62021-12-02T16:32:02ZCirculating branch chain amino acids and improvement in liver fat content in response to exercise interventions in NAFLD10.1038/s41598-021-92918-12045-2322https://doaj.org/article/d126c1939f174743937c4edb8b6673b62021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92918-1https://doaj.org/toc/2045-2322Abstract Nonalcoholic fatty liver disease is likely to be associated with increased circulating branched-chain amino acids. We investigated the relationship between changes in branched-chain amino acids levels in the serum and improvement in liver fat content caused by exercise intervention in individuals with nonalcoholic fatty liver disease. The exploratory study included 208 central obesity and nonalcoholic fatty liver disease individuals from an exercise intervention randomized clinical trial for nonalcoholic fatty liver disease. The participants were randomly assigned to control, moderate, and vigorous-moderate exercise groups for 12 months. Changes in total branched-chain amino acids, leucine, isoleucine, and valine levels from baseline to 6 months were calculated. Liver fat content was determined by proton magnetic resonance spectroscopy. Reductions in circulating levels of total branched-chain amino acids, leucine, and valine levels from baseline to 6 months were significantly associated with the improvement of liver fat content at 6 months and 12 months (p < 0.01 for all) after adjustments for age, sex, total energy intake, protein intake, intervention groups, HOMA-IR, BMI, liver fat content, total branched-chain amino acids, leucine, and valine at baseline, respectively. These associations were still significant after further adjustments for changes in HOMA-IR and BMI from baseline to 6 months (p < 0.05 for all). Our findings indicated that reductions in circulating branched-chain amino acids levels were associated with an improvement in liver fat content by exercise intervention among patients with nonalcoholic fatty liver disease, which was independent of changes in BMI or HOMA-IR.Xiulin ShiHongyan YinJia LiCaoxin HuangYinling ChenZheng ChenWei LiuWeijuan SuYiping ZhangMingzhu LinYan ZhaoXuejun LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiulin Shi Hongyan Yin Jia Li Caoxin Huang Yinling Chen Zheng Chen Wei Liu Weijuan Su Yiping Zhang Mingzhu Lin Yan Zhao Xuejun Li Circulating branch chain amino acids and improvement in liver fat content in response to exercise interventions in NAFLD
description	Abstract Nonalcoholic fatty liver disease is likely to be associated with increased circulating branched-chain amino acids. We investigated the relationship between changes in branched-chain amino acids levels in the serum and improvement in liver fat content caused by exercise intervention in individuals with nonalcoholic fatty liver disease. The exploratory study included 208 central obesity and nonalcoholic fatty liver disease individuals from an exercise intervention randomized clinical trial for nonalcoholic fatty liver disease. The participants were randomly assigned to control, moderate, and vigorous-moderate exercise groups for 12 months. Changes in total branched-chain amino acids, leucine, isoleucine, and valine levels from baseline to 6 months were calculated. Liver fat content was determined by proton magnetic resonance spectroscopy. Reductions in circulating levels of total branched-chain amino acids, leucine, and valine levels from baseline to 6 months were significantly associated with the improvement of liver fat content at 6 months and 12 months (p < 0.01 for all) after adjustments for age, sex, total energy intake, protein intake, intervention groups, HOMA-IR, BMI, liver fat content, total branched-chain amino acids, leucine, and valine at baseline, respectively. These associations were still significant after further adjustments for changes in HOMA-IR and BMI from baseline to 6 months (p < 0.05 for all). Our findings indicated that reductions in circulating branched-chain amino acids levels were associated with an improvement in liver fat content by exercise intervention among patients with nonalcoholic fatty liver disease, which was independent of changes in BMI or HOMA-IR.
format	article
author	Xiulin Shi Hongyan Yin Jia Li Caoxin Huang Yinling Chen Zheng Chen Wei Liu Weijuan Su Yiping Zhang Mingzhu Lin Yan Zhao Xuejun Li
author_facet	Xiulin Shi Hongyan Yin Jia Li Caoxin Huang Yinling Chen Zheng Chen Wei Liu Weijuan Su Yiping Zhang Mingzhu Lin Yan Zhao Xuejun Li
author_sort	Xiulin Shi
title	Circulating branch chain amino acids and improvement in liver fat content in response to exercise interventions in NAFLD
title_short	Circulating branch chain amino acids and improvement in liver fat content in response to exercise interventions in NAFLD
title_full	Circulating branch chain amino acids and improvement in liver fat content in response to exercise interventions in NAFLD
title_fullStr	Circulating branch chain amino acids and improvement in liver fat content in response to exercise interventions in NAFLD
title_full_unstemmed	Circulating branch chain amino acids and improvement in liver fat content in response to exercise interventions in NAFLD
title_sort	circulating branch chain amino acids and improvement in liver fat content in response to exercise interventions in nafld
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d126c1939f174743937c4edb8b6673b6
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Circulating branch chain amino acids and improvement in liver fat content in response to exercise interventions in NAFLD

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