Reduced readiness potential and post-movement beta synchronization reflect self-disorders in early course schizophrenia

Abstract Disturbances of conscious awareness, or self-disorders, are a defining feature of schizophrenia. These include symptoms such as delusions of control, i.e. the belief that one’s actions are controlled by an external agent. Models of self-disorders point at altered neural mechanisms of source...

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Autores principales:	Francesco Luciano Donati, Matteo Fecchio, Davide Maestri, Mattia Cornali, Chiara Camilla Derchi, Cecilia Casetta, Maristella Zalaffi, Corrado Sinigaglia, Simone Sarasso, Armando D’Agostino
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d127388bc85c4630a39649d80d4e0ac9
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spelling	oai:doaj.org-article:d127388bc85c4630a39649d80d4e0ac92021-12-02T16:17:17ZReduced readiness potential and post-movement beta synchronization reflect self-disorders in early course schizophrenia10.1038/s41598-021-94356-52045-2322https://doaj.org/article/d127388bc85c4630a39649d80d4e0ac92021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94356-5https://doaj.org/toc/2045-2322Abstract Disturbances of conscious awareness, or self-disorders, are a defining feature of schizophrenia. These include symptoms such as delusions of control, i.e. the belief that one’s actions are controlled by an external agent. Models of self-disorders point at altered neural mechanisms of source monitoring, i.e. the ability of the brain to discriminate self-generated stimuli from those driven by the environment. However, evidence supporting this putative relationship is currently lacking. We performed electroencephalography (EEG) during self-paced, brisk right fist closures in ten (M = 9; F = 1) patients with Early-Course Schizophrenia (ECSCZ) and age and gender-matched healthy volunteers. We measured the Readiness Potential (RP), i.e. an EEG feature preceding self-generated movements, and movement-related EEG spectral changes. Self-disorders in ECSCZ were assessed with the Examination of Anomalous Self-Experience (EASE). Patients showed a markedly reduced RP and altered post-movement Event-Related Synchronization (ERS) in the beta frequency band (14–24 Hz) compared to healthy controls. Importantly, smaller RP and weaker ERS were associated with higher EASE scores in ECSCZ. Our data suggest that disturbances of neural correlates preceding and following self-initiated movements may reflect the severity of self-disorders in patients suffering from ECSCZ. These findings point towards deficits in basic mechanisms of sensorimotor integration as a substrate for self-disorders.Francesco Luciano DonatiMatteo FecchioDavide MaestriMattia CornaliChiara Camilla DerchiCecilia CasettaMaristella ZalaffiCorrado SinigagliaSimone SarassoArmando D’AgostinoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Francesco Luciano Donati Matteo Fecchio Davide Maestri Mattia Cornali Chiara Camilla Derchi Cecilia Casetta Maristella Zalaffi Corrado Sinigaglia Simone Sarasso Armando D’Agostino Reduced readiness potential and post-movement beta synchronization reflect self-disorders in early course schizophrenia
description	Abstract Disturbances of conscious awareness, or self-disorders, are a defining feature of schizophrenia. These include symptoms such as delusions of control, i.e. the belief that one’s actions are controlled by an external agent. Models of self-disorders point at altered neural mechanisms of source monitoring, i.e. the ability of the brain to discriminate self-generated stimuli from those driven by the environment. However, evidence supporting this putative relationship is currently lacking. We performed electroencephalography (EEG) during self-paced, brisk right fist closures in ten (M = 9; F = 1) patients with Early-Course Schizophrenia (ECSCZ) and age and gender-matched healthy volunteers. We measured the Readiness Potential (RP), i.e. an EEG feature preceding self-generated movements, and movement-related EEG spectral changes. Self-disorders in ECSCZ were assessed with the Examination of Anomalous Self-Experience (EASE). Patients showed a markedly reduced RP and altered post-movement Event-Related Synchronization (ERS) in the beta frequency band (14–24 Hz) compared to healthy controls. Importantly, smaller RP and weaker ERS were associated with higher EASE scores in ECSCZ. Our data suggest that disturbances of neural correlates preceding and following self-initiated movements may reflect the severity of self-disorders in patients suffering from ECSCZ. These findings point towards deficits in basic mechanisms of sensorimotor integration as a substrate for self-disorders.
format	article
author	Francesco Luciano Donati Matteo Fecchio Davide Maestri Mattia Cornali Chiara Camilla Derchi Cecilia Casetta Maristella Zalaffi Corrado Sinigaglia Simone Sarasso Armando D’Agostino
author_facet	Francesco Luciano Donati Matteo Fecchio Davide Maestri Mattia Cornali Chiara Camilla Derchi Cecilia Casetta Maristella Zalaffi Corrado Sinigaglia Simone Sarasso Armando D’Agostino
author_sort	Francesco Luciano Donati
title	Reduced readiness potential and post-movement beta synchronization reflect self-disorders in early course schizophrenia
title_short	Reduced readiness potential and post-movement beta synchronization reflect self-disorders in early course schizophrenia
title_full	Reduced readiness potential and post-movement beta synchronization reflect self-disorders in early course schizophrenia
title_fullStr	Reduced readiness potential and post-movement beta synchronization reflect self-disorders in early course schizophrenia
title_full_unstemmed	Reduced readiness potential and post-movement beta synchronization reflect self-disorders in early course schizophrenia
title_sort	reduced readiness potential and post-movement beta synchronization reflect self-disorders in early course schizophrenia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d127388bc85c4630a39649d80d4e0ac9
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Reduced readiness potential and post-movement beta synchronization reflect self-disorders in early course schizophrenia

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