Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1

Ataxin-1, linked to spinocerebellar ataxia type 1, is known to interact with the orphan nuclear receptor RORα. Here, Fujita and colleagues show that genetic supplementation of RORα-interacting protein YAPdeltaC during early development can rescue the adult pathologies of SCA1 mouse model.

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Autores principales:	Kyota Fujita, Ying Mao, Shigenori Uchida, Xigui Chen, Hiroki Shiwaku, Takuya Tamura, Hikaru Ito, Kei Watase, Hidenori Homma, Kazuhiko Tagawa, Marius Sudol, Hitoshi Okazawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d12cc52f03a847f3a9b99a8f14c82965
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spelling	oai:doaj.org-article:d12cc52f03a847f3a9b99a8f14c829652021-12-02T14:40:45ZDevelopmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 110.1038/s41467-017-01790-z2041-1723https://doaj.org/article/d12cc52f03a847f3a9b99a8f14c829652017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01790-zhttps://doaj.org/toc/2041-1723Ataxin-1, linked to spinocerebellar ataxia type 1, is known to interact with the orphan nuclear receptor RORα. Here, Fujita and colleagues show that genetic supplementation of RORα-interacting protein YAPdeltaC during early development can rescue the adult pathologies of SCA1 mouse model.Kyota FujitaYing MaoShigenori UchidaXigui ChenHiroki ShiwakuTakuya TamuraHikaru ItoKei WataseHidenori HommaKazuhiko TagawaMarius SudolHitoshi OkazawaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kyota Fujita Ying Mao Shigenori Uchida Xigui Chen Hiroki Shiwaku Takuya Tamura Hikaru Ito Kei Watase Hidenori Homma Kazuhiko Tagawa Marius Sudol Hitoshi Okazawa Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1
description	Ataxin-1, linked to spinocerebellar ataxia type 1, is known to interact with the orphan nuclear receptor RORα. Here, Fujita and colleagues show that genetic supplementation of RORα-interacting protein YAPdeltaC during early development can rescue the adult pathologies of SCA1 mouse model.
format	article
author	Kyota Fujita Ying Mao Shigenori Uchida Xigui Chen Hiroki Shiwaku Takuya Tamura Hikaru Ito Kei Watase Hidenori Homma Kazuhiko Tagawa Marius Sudol Hitoshi Okazawa
author_facet	Kyota Fujita Ying Mao Shigenori Uchida Xigui Chen Hiroki Shiwaku Takuya Tamura Hikaru Ito Kei Watase Hidenori Homma Kazuhiko Tagawa Marius Sudol Hitoshi Okazawa
author_sort	Kyota Fujita
title	Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1
title_short	Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1
title_full	Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1
title_fullStr	Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1
title_full_unstemmed	Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1
title_sort	developmental yapdeltac determines adult pathology in a model of spinocerebellar ataxia type 1
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d12cc52f03a847f3a9b99a8f14c82965
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Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1

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