Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1

Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1

Ataxin-1, linked to spinocerebellar ataxia type 1, is known to interact with the orphan nuclear receptor RORα. Here, Fujita and colleagues show that genetic supplementation of RORα-interacting protein YAPdeltaC during early development can rescue the adult pathologies of SCA1 mouse model.

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Detalles Bibliográficos
Autores principales: Kyota Fujita, Ying Mao, Shigenori Uchida, Xigui Chen, Hiroki Shiwaku, Takuya Tamura, Hikaru Ito, Kei Watase, Hidenori Homma, Kazuhiko Tagawa, Marius Sudol, Hitoshi Okazawa
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/d12cc52f03a847f3a9b99a8f14c82965
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