Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia

Chronic lymphocytic leukaemia (CLL) is characterized by cell-autonomous B-cell receptor (BcR)-mediated signalling of neoplastic B lymphocytes. Here the authors unveil the structural basis and diversity of activatory homotypic BcR contacts and link them with CLL heterogeneity and the clinical outcome...

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Autores principales:	Claudia Minici, Maria Gounari, Rudolf Übelhart, Lydia Scarfò, Marcus Dühren-von Minden, Dunja Schneider, Alpaslan Tasdogan, Alabbas Alkhatib, Andreas Agathangelidis, Stavroula Ntoufa, Nicholas Chiorazzi, Hassan Jumaa, Kostas Stamatopoulos, Paolo Ghia, Massimo Degano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d134c066cc4e4ceb916cfd21f5f03500
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spelling	oai:doaj.org-article:d134c066cc4e4ceb916cfd21f5f035002021-12-02T14:40:49ZDistinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia10.1038/ncomms157462041-1723https://doaj.org/article/d134c066cc4e4ceb916cfd21f5f035002017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15746https://doaj.org/toc/2041-1723Chronic lymphocytic leukaemia (CLL) is characterized by cell-autonomous B-cell receptor (BcR)-mediated signalling of neoplastic B lymphocytes. Here the authors unveil the structural basis and diversity of activatory homotypic BcR contacts and link them with CLL heterogeneity and the clinical outcome.Claudia MiniciMaria GounariRudolf ÜbelhartLydia ScarfòMarcus Dühren-von MindenDunja SchneiderAlpaslan TasdoganAlabbas AlkhatibAndreas AgathangelidisStavroula NtoufaNicholas ChiorazziHassan JumaaKostas StamatopoulosPaolo GhiaMassimo DeganoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Claudia Minici Maria Gounari Rudolf Übelhart Lydia Scarfò Marcus Dühren-von Minden Dunja Schneider Alpaslan Tasdogan Alabbas Alkhatib Andreas Agathangelidis Stavroula Ntoufa Nicholas Chiorazzi Hassan Jumaa Kostas Stamatopoulos Paolo Ghia Massimo Degano Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia
description	Chronic lymphocytic leukaemia (CLL) is characterized by cell-autonomous B-cell receptor (BcR)-mediated signalling of neoplastic B lymphocytes. Here the authors unveil the structural basis and diversity of activatory homotypic BcR contacts and link them with CLL heterogeneity and the clinical outcome.
format	article
author	Claudia Minici Maria Gounari Rudolf Übelhart Lydia Scarfò Marcus Dühren-von Minden Dunja Schneider Alpaslan Tasdogan Alabbas Alkhatib Andreas Agathangelidis Stavroula Ntoufa Nicholas Chiorazzi Hassan Jumaa Kostas Stamatopoulos Paolo Ghia Massimo Degano
author_facet	Claudia Minici Maria Gounari Rudolf Übelhart Lydia Scarfò Marcus Dühren-von Minden Dunja Schneider Alpaslan Tasdogan Alabbas Alkhatib Andreas Agathangelidis Stavroula Ntoufa Nicholas Chiorazzi Hassan Jumaa Kostas Stamatopoulos Paolo Ghia Massimo Degano
author_sort	Claudia Minici
title	Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia
title_short	Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia
title_full	Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia
title_fullStr	Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia
title_full_unstemmed	Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia
title_sort	distinct homotypic b-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d134c066cc4e4ceb916cfd21f5f03500
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Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia

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