MiR-18a-5p Facilitates Progression of Hepatocellular Carcinoma by Targeting CPEB3

Objective: To explore the function of the miR-18a-5p/CPEB3 axis in regulating the occurrence of hepatocellular carcinoma (HCC). Methods: Differentially expressed miRNAs and mRNAs were acquired by bioinformatics analysis. qRT-PCR was used for miR-18a-5p and CPEB3 mRNA expression detection. Cell funct...

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Autores principales:	Mingxin Cui MM, Fengzhi Qu MM, Libing Wang MM, Daming Cheng MB, Xiaogang Liu MM
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/d13529c889cf421d859dfe77aae6f6d7
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id	oai:doaj.org-article:d13529c889cf421d859dfe77aae6f6d7
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spelling	oai:doaj.org-article:d13529c889cf421d859dfe77aae6f6d72021-11-05T22:33:23ZMiR-18a-5p Facilitates Progression of Hepatocellular Carcinoma by Targeting CPEB31533-033810.1177/15330338211043976https://doaj.org/article/d13529c889cf421d859dfe77aae6f6d72021-11-01T00:00:00Zhttps://doi.org/10.1177/15330338211043976https://doaj.org/toc/1533-0338Objective: To explore the function of the miR-18a-5p/CPEB3 axis in regulating the occurrence of hepatocellular carcinoma (HCC). Methods: Differentially expressed miRNAs and mRNAs were acquired by bioinformatics analysis. qRT-PCR was used for miR-18a-5p and CPEB3 mRNA expression detection. Cell functional assays were implemented to examine the biological functions of HCC cells. The binding relationship between miR-18a-5p and CPEB3 was verified by a dual luciferase assay. Results: In HCC, miR-18a-5p was remarkably highly expressed, while CPEB3 was markedly lowly expressed. HCC cell progression was facilitated after cells transfecting miR-18a-5p mimic, whereas silencing miR-18a-5p caused the opposite result. Overexpressing CPEB3 could restore promoting effect of miR-18a-5p on the growth of HCC cells. Conclusion: Oncogene miR-18a-5p accelerates malignant phenotype by suppressing CPEB3. MiR-18a-5p/CPEB3 axis in HCC identified in this study provides a new target for HCC treatment.Mingxin Cui MMFengzhi Qu MMLibing Wang MMDaming Cheng MBXiaogang Liu MMSAGE PublishingarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENTechnology in Cancer Research & Treatment, Vol 20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Mingxin Cui MM Fengzhi Qu MM Libing Wang MM Daming Cheng MB Xiaogang Liu MM MiR-18a-5p Facilitates Progression of Hepatocellular Carcinoma by Targeting CPEB3
description	Objective: To explore the function of the miR-18a-5p/CPEB3 axis in regulating the occurrence of hepatocellular carcinoma (HCC). Methods: Differentially expressed miRNAs and mRNAs were acquired by bioinformatics analysis. qRT-PCR was used for miR-18a-5p and CPEB3 mRNA expression detection. Cell functional assays were implemented to examine the biological functions of HCC cells. The binding relationship between miR-18a-5p and CPEB3 was verified by a dual luciferase assay. Results: In HCC, miR-18a-5p was remarkably highly expressed, while CPEB3 was markedly lowly expressed. HCC cell progression was facilitated after cells transfecting miR-18a-5p mimic, whereas silencing miR-18a-5p caused the opposite result. Overexpressing CPEB3 could restore promoting effect of miR-18a-5p on the growth of HCC cells. Conclusion: Oncogene miR-18a-5p accelerates malignant phenotype by suppressing CPEB3. MiR-18a-5p/CPEB3 axis in HCC identified in this study provides a new target for HCC treatment.
format	article
author	Mingxin Cui MM Fengzhi Qu MM Libing Wang MM Daming Cheng MB Xiaogang Liu MM
author_facet	Mingxin Cui MM Fengzhi Qu MM Libing Wang MM Daming Cheng MB Xiaogang Liu MM
author_sort	Mingxin Cui MM
title	MiR-18a-5p Facilitates Progression of Hepatocellular Carcinoma by Targeting CPEB3
title_short	MiR-18a-5p Facilitates Progression of Hepatocellular Carcinoma by Targeting CPEB3
title_full	MiR-18a-5p Facilitates Progression of Hepatocellular Carcinoma by Targeting CPEB3
title_fullStr	MiR-18a-5p Facilitates Progression of Hepatocellular Carcinoma by Targeting CPEB3
title_full_unstemmed	MiR-18a-5p Facilitates Progression of Hepatocellular Carcinoma by Targeting CPEB3
title_sort	mir-18a-5p facilitates progression of hepatocellular carcinoma by targeting cpeb3
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/d13529c889cf421d859dfe77aae6f6d7
work_keys_str_mv	AT mingxincuimm mir18a5pfacilitatesprogressionofhepatocellularcarcinomabytargetingcpeb3 AT fengzhiqumm mir18a5pfacilitatesprogressionofhepatocellularcarcinomabytargetingcpeb3 AT libingwangmm mir18a5pfacilitatesprogressionofhepatocellularcarcinomabytargetingcpeb3 AT damingchengmb mir18a5pfacilitatesprogressionofhepatocellularcarcinomabytargetingcpeb3 AT xiaogangliumm mir18a5pfacilitatesprogressionofhepatocellularcarcinomabytargetingcpeb3
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MiR-18a-5p Facilitates Progression of Hepatocellular Carcinoma by Targeting CPEB3

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