Malignancy risk analysis in patients with inadequate fine needle aspiration cytology (FNAC) of the thyroid.

<h4>Background</h4>Thyroid fine needle aspiration cytology (FNAC) is the standard diagnostic modality for thyroid nodules. However, it has limitations among which is the incidence of non-diagnostic results (Thy1). Management of cases with repeatedly non-diagnostic FNAC ranges from simple...

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Autores principales:	Talib Al Maqbali, Miroslav Tedla, Martin O Weickert, Hisham Mehanna
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d13693fb63e9482e9a3ccd6ab3550fb5
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spelling	oai:doaj.org-article:d13693fb63e9482e9a3ccd6ab3550fb52021-11-18T08:08:19ZMalignancy risk analysis in patients with inadequate fine needle aspiration cytology (FNAC) of the thyroid.1932-620310.1371/journal.pone.0049078https://doaj.org/article/d13693fb63e9482e9a3ccd6ab3550fb52012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23185295/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Thyroid fine needle aspiration cytology (FNAC) is the standard diagnostic modality for thyroid nodules. However, it has limitations among which is the incidence of non-diagnostic results (Thy1). Management of cases with repeatedly non-diagnostic FNAC ranges from simple observation to surgical intervention. We aim to evaluate the incidence of malignancy in non-diagnostic FNAC, and the success rate of repeated FNAC. We also aim to evaluate risk factors for malignancy in patients with non-diagnostic FNAC.<h4>Materials and methods</h4>Retrospective analyses of consecutive cases with thyroid non diagnostic FNAC results were included.<h4>Results</h4>Out of total 1657 thyroid FNAC done during the study period, there were 264 (15.9%) non-diagnostic FNAC on the first attempt. On repeating those, the rate of a non-diagnostic result on second FNAC was 61.8% and on third FNAC was 47.2%. The overall malignancy rate in Thy1 FNAC was 4.5% (42% papillary, 42% follicular and 8% anaplastic), and the yield of malignancy decreased considerably with successive non-diagnostic FNAC. Ultrasound guidance by an experienced head neck radiologist produced the lowest non-diagnostic rate (38%) on repetition compared to US guidance by a generalist radiologist (65%) and by non US guidance (90%).<h4>Conclusions</h4>There is a low risk of malignancy in patients with a non-diagnostic FNAC result, commensurate to the risk of any nodule. The yield of malignancy decreased considerably with successive non-diagnostic FNAC.Talib Al MaqbaliMiroslav TedlaMartin O WeickertHisham MehannaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e49078 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Talib Al Maqbali Miroslav Tedla Martin O Weickert Hisham Mehanna Malignancy risk analysis in patients with inadequate fine needle aspiration cytology (FNAC) of the thyroid.
description	<h4>Background</h4>Thyroid fine needle aspiration cytology (FNAC) is the standard diagnostic modality for thyroid nodules. However, it has limitations among which is the incidence of non-diagnostic results (Thy1). Management of cases with repeatedly non-diagnostic FNAC ranges from simple observation to surgical intervention. We aim to evaluate the incidence of malignancy in non-diagnostic FNAC, and the success rate of repeated FNAC. We also aim to evaluate risk factors for malignancy in patients with non-diagnostic FNAC.<h4>Materials and methods</h4>Retrospective analyses of consecutive cases with thyroid non diagnostic FNAC results were included.<h4>Results</h4>Out of total 1657 thyroid FNAC done during the study period, there were 264 (15.9%) non-diagnostic FNAC on the first attempt. On repeating those, the rate of a non-diagnostic result on second FNAC was 61.8% and on third FNAC was 47.2%. The overall malignancy rate in Thy1 FNAC was 4.5% (42% papillary, 42% follicular and 8% anaplastic), and the yield of malignancy decreased considerably with successive non-diagnostic FNAC. Ultrasound guidance by an experienced head neck radiologist produced the lowest non-diagnostic rate (38%) on repetition compared to US guidance by a generalist radiologist (65%) and by non US guidance (90%).<h4>Conclusions</h4>There is a low risk of malignancy in patients with a non-diagnostic FNAC result, commensurate to the risk of any nodule. The yield of malignancy decreased considerably with successive non-diagnostic FNAC.
format	article
author	Talib Al Maqbali Miroslav Tedla Martin O Weickert Hisham Mehanna
author_facet	Talib Al Maqbali Miroslav Tedla Martin O Weickert Hisham Mehanna
author_sort	Talib Al Maqbali
title	Malignancy risk analysis in patients with inadequate fine needle aspiration cytology (FNAC) of the thyroid.
title_short	Malignancy risk analysis in patients with inadequate fine needle aspiration cytology (FNAC) of the thyroid.
title_full	Malignancy risk analysis in patients with inadequate fine needle aspiration cytology (FNAC) of the thyroid.
title_fullStr	Malignancy risk analysis in patients with inadequate fine needle aspiration cytology (FNAC) of the thyroid.
title_full_unstemmed	Malignancy risk analysis in patients with inadequate fine needle aspiration cytology (FNAC) of the thyroid.
title_sort	malignancy risk analysis in patients with inadequate fine needle aspiration cytology (fnac) of the thyroid.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/d13693fb63e9482e9a3ccd6ab3550fb5
work_keys_str_mv	AT talibalmaqbali malignancyriskanalysisinpatientswithinadequatefineneedleaspirationcytologyfnacofthethyroid AT miroslavtedla malignancyriskanalysisinpatientswithinadequatefineneedleaspirationcytologyfnacofthethyroid AT martinoweickert malignancyriskanalysisinpatientswithinadequatefineneedleaspirationcytologyfnacofthethyroid AT hishammehanna malignancyriskanalysisinpatientswithinadequatefineneedleaspirationcytologyfnacofthethyroid
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Malignancy risk analysis in patients with inadequate fine needle aspiration cytology (FNAC) of the thyroid.

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