Age and Sex Specific Prevalence of Clinical and Screen-Detected Atrial Fibrillation in Hospitalized Patients

Background: The prevalence of atrial fibrillation (AF) is high in older patients. The present study aimed to estimate the age and sex specific prevalence of clinical and screen-detected atrial fibrillation (AF) in hospitalized patients. Methods: The STAR-FIB cohort study was a prospective cohort stu...

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Autores principales:	Laurent Roten, Eleni Goulouti, Anna Lam, Elena Elchinova, Nikolas Nozica, Alessandro Spirito, Severin Wittmer, Mattia Branca, Helge Servatius, Fabian Noti, Jens Seiler, Samuel H Baldinger, Andreas Haeberlin, Stefano de Marchi, Babken Asatryan, Nicolas Rodondi, Jacques Donzé, Drahomir Aujesky, Hildegard Tanner, Tobias Reichlin, Peter Jüni
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	atrial fibrillation screening paroxysmal subclinical silent Holter ECG Medicine R
Acceso en línea:	https://doaj.org/article/d13d828289654bbf87cc80d5da7587c6
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spelling	oai:doaj.org-article:d13d828289654bbf87cc80d5da7587c62021-11-11T17:31:53ZAge and Sex Specific Prevalence of Clinical and Screen-Detected Atrial Fibrillation in Hospitalized Patients10.3390/jcm102148712077-0383https://doaj.org/article/d13d828289654bbf87cc80d5da7587c62021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4871https://doaj.org/toc/2077-0383Background: The prevalence of atrial fibrillation (AF) is high in older patients. The present study aimed to estimate the age and sex specific prevalence of clinical and screen-detected atrial fibrillation (AF) in hospitalized patients. Methods: The STAR-FIB cohort study was a prospective cohort study recruiting participants from a large source population of hospitalized patients aged 65–84 years. The estimated size of the source population was 26,035 (95% CI 25,918–26,152), and 795 consenting patients without clinical AF were included in the cohort study after stratification by sex and age (49.2% females; mean age 74.7 years). Patients in the cohort study underwent three seven-day Holter ECGs in intervals of two months to screen for AF. Results: In the source population, the estimated prevalence of clinical AF was 22.2% (95% CI 18.4–26.1), 23.8% for males (95% CI 20.9–26.6) and 19.8% for females (95% CI 17.3–22.4; <i>p</i> for difference between sexes, 0.004). There was a linear trend for an increase in the prevalence of clinical AF with increasing age, overall and in both sexes. In the cohort study, AF was newly diagnosed in 38 patients, for an estimated prevalence of screen-detected AF of 4.9% overall (95% CI 3.3–6.6), 5.5% in males (95% CI 3.2–7.8) and 4.0% in females (95% CI 2.0–6.0; <i>p</i> for difference between sexes, 0.041). The estimated prevalence of screen-detected AF in the source population was 3.8% overall, 4.2% in males and 3.2% in females. Conclusion: In a large hospital-based patient population aged 65–84 years, the prevalence of clinical AF and of screen-detected AF was 22.2% and 3.8%, respectively, and significantly higher in males than females.Laurent RotenEleni GouloutiAnna LamElena ElchinovaNikolas NozicaAlessandro SpiritoSeverin WittmerMattia BrancaHelge ServatiusFabian NotiJens SeilerSamuel H BaldingerAndreas HaeberlinStefano de MarchiBabken AsatryanNicolas RodondiJacques DonzéDrahomir AujeskyHildegard TannerTobias ReichlinPeter JüniMDPI AGarticleatrial fibrillationscreeningparoxysmalsubclinicalsilentHolter ECGMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4871, p 4871 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	atrial fibrillation screening paroxysmal subclinical silent Holter ECG Medicine R
spellingShingle	atrial fibrillation screening paroxysmal subclinical silent Holter ECG Medicine R Laurent Roten Eleni Goulouti Anna Lam Elena Elchinova Nikolas Nozica Alessandro Spirito Severin Wittmer Mattia Branca Helge Servatius Fabian Noti Jens Seiler Samuel H Baldinger Andreas Haeberlin Stefano de Marchi Babken Asatryan Nicolas Rodondi Jacques Donzé Drahomir Aujesky Hildegard Tanner Tobias Reichlin Peter Jüni Age and Sex Specific Prevalence of Clinical and Screen-Detected Atrial Fibrillation in Hospitalized Patients
description	Background: The prevalence of atrial fibrillation (AF) is high in older patients. The present study aimed to estimate the age and sex specific prevalence of clinical and screen-detected atrial fibrillation (AF) in hospitalized patients. Methods: The STAR-FIB cohort study was a prospective cohort study recruiting participants from a large source population of hospitalized patients aged 65–84 years. The estimated size of the source population was 26,035 (95% CI 25,918–26,152), and 795 consenting patients without clinical AF were included in the cohort study after stratification by sex and age (49.2% females; mean age 74.7 years). Patients in the cohort study underwent three seven-day Holter ECGs in intervals of two months to screen for AF. Results: In the source population, the estimated prevalence of clinical AF was 22.2% (95% CI 18.4–26.1), 23.8% for males (95% CI 20.9–26.6) and 19.8% for females (95% CI 17.3–22.4; <i>p</i> for difference between sexes, 0.004). There was a linear trend for an increase in the prevalence of clinical AF with increasing age, overall and in both sexes. In the cohort study, AF was newly diagnosed in 38 patients, for an estimated prevalence of screen-detected AF of 4.9% overall (95% CI 3.3–6.6), 5.5% in males (95% CI 3.2–7.8) and 4.0% in females (95% CI 2.0–6.0; <i>p</i> for difference between sexes, 0.041). The estimated prevalence of screen-detected AF in the source population was 3.8% overall, 4.2% in males and 3.2% in females. Conclusion: In a large hospital-based patient population aged 65–84 years, the prevalence of clinical AF and of screen-detected AF was 22.2% and 3.8%, respectively, and significantly higher in males than females.
format	article
author	Laurent Roten Eleni Goulouti Anna Lam Elena Elchinova Nikolas Nozica Alessandro Spirito Severin Wittmer Mattia Branca Helge Servatius Fabian Noti Jens Seiler Samuel H Baldinger Andreas Haeberlin Stefano de Marchi Babken Asatryan Nicolas Rodondi Jacques Donzé Drahomir Aujesky Hildegard Tanner Tobias Reichlin Peter Jüni
author_facet	Laurent Roten Eleni Goulouti Anna Lam Elena Elchinova Nikolas Nozica Alessandro Spirito Severin Wittmer Mattia Branca Helge Servatius Fabian Noti Jens Seiler Samuel H Baldinger Andreas Haeberlin Stefano de Marchi Babken Asatryan Nicolas Rodondi Jacques Donzé Drahomir Aujesky Hildegard Tanner Tobias Reichlin Peter Jüni
author_sort	Laurent Roten
title	Age and Sex Specific Prevalence of Clinical and Screen-Detected Atrial Fibrillation in Hospitalized Patients
title_short	Age and Sex Specific Prevalence of Clinical and Screen-Detected Atrial Fibrillation in Hospitalized Patients
title_full	Age and Sex Specific Prevalence of Clinical and Screen-Detected Atrial Fibrillation in Hospitalized Patients
title_fullStr	Age and Sex Specific Prevalence of Clinical and Screen-Detected Atrial Fibrillation in Hospitalized Patients
title_full_unstemmed	Age and Sex Specific Prevalence of Clinical and Screen-Detected Atrial Fibrillation in Hospitalized Patients
title_sort	age and sex specific prevalence of clinical and screen-detected atrial fibrillation in hospitalized patients
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d13d828289654bbf87cc80d5da7587c6
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Age and Sex Specific Prevalence of Clinical and Screen-Detected Atrial Fibrillation in Hospitalized Patients

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