Adipose gene expression prior to weight loss can differentiate and weakly predict dietary responders.

<h4>Background</h4>The ability to identify obese individuals who will successfully lose weight in response to dietary intervention will revolutionize disease management. Therefore, we asked whether it is possible to identify subjects who will lose weight during dietary intervention using...

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Autores principales: David M Mutch, M Ramzi Temanni, Corneliu Henegar, Florence Combes, Véronique Pelloux, Claus Holst, Thorkild I A Sørensen, Arne Astrup, J Alfredo Martinez, Wim H M Saris, Nathalie Viguerie, Dominique Langin, Jean-Daniel Zucker, Karine Clément
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Publicado: Public Library of Science (PLoS) 2007
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spelling oai:doaj.org-article:d13e11834ce94b149fe08fae7010428b2021-11-25T06:13:38ZAdipose gene expression prior to weight loss can differentiate and weakly predict dietary responders.1932-620310.1371/journal.pone.0001344https://doaj.org/article/d13e11834ce94b149fe08fae7010428b2007-12-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0001344https://doaj.org/toc/1932-6203<h4>Background</h4>The ability to identify obese individuals who will successfully lose weight in response to dietary intervention will revolutionize disease management. Therefore, we asked whether it is possible to identify subjects who will lose weight during dietary intervention using only a single gene expression snapshot.<h4>Methodology/principal findings</h4>The present study involved 54 female subjects from the Nutrient-Gene Interactions in Human Obesity-Implications for Dietary Guidelines (NUGENOB) trial to determine whether subcutaneous adipose tissue gene expression could be used to predict weight loss prior to the 10-week consumption of a low-fat hypocaloric diet. Using several statistical tests revealed that the gene expression profiles of responders (8-12 kgs weight loss) could always be differentiated from non-responders (<4 kgs weight loss). We also assessed whether this differentiation was sufficient for prediction. Using a bottom-up (i.e. black-box) approach, standard class prediction algorithms were able to predict dietary responders with up to 61.1%+/-8.1% accuracy. Using a top-down approach (i.e. using differentially expressed genes to build a classifier) improved prediction accuracy to 80.9%+/-2.2%.<h4>Conclusion</h4>Adipose gene expression profiling prior to the consumption of a low-fat diet is able to differentiate responders from non-responders as well as serve as a weak predictor of subjects destined to lose weight. While the degree of prediction accuracy currently achieved with a gene expression snapshot is perhaps insufficient for clinical use, this work reveals that the comprehensive molecular signature of adipose tissue paves the way for the future of personalized nutrition.David M MutchM Ramzi TemanniCorneliu HenegarFlorence CombesFlorence CombesVéronique PellouxClaus HolstThorkild I A SørensenArne AstrupJ Alfredo MartinezWim H M SarisNathalie ViguerieDominique LanginJean-Daniel ZuckerKarine ClémentPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 2, Iss 12, p e1344 (2007)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
David M Mutch
M Ramzi Temanni
Corneliu Henegar
Florence Combes
Florence Combes
Véronique Pelloux
Claus Holst
Thorkild I A Sørensen
Arne Astrup
J Alfredo Martinez
Wim H M Saris
Nathalie Viguerie
Dominique Langin
Jean-Daniel Zucker
Karine Clément
Adipose gene expression prior to weight loss can differentiate and weakly predict dietary responders.
description <h4>Background</h4>The ability to identify obese individuals who will successfully lose weight in response to dietary intervention will revolutionize disease management. Therefore, we asked whether it is possible to identify subjects who will lose weight during dietary intervention using only a single gene expression snapshot.<h4>Methodology/principal findings</h4>The present study involved 54 female subjects from the Nutrient-Gene Interactions in Human Obesity-Implications for Dietary Guidelines (NUGENOB) trial to determine whether subcutaneous adipose tissue gene expression could be used to predict weight loss prior to the 10-week consumption of a low-fat hypocaloric diet. Using several statistical tests revealed that the gene expression profiles of responders (8-12 kgs weight loss) could always be differentiated from non-responders (<4 kgs weight loss). We also assessed whether this differentiation was sufficient for prediction. Using a bottom-up (i.e. black-box) approach, standard class prediction algorithms were able to predict dietary responders with up to 61.1%+/-8.1% accuracy. Using a top-down approach (i.e. using differentially expressed genes to build a classifier) improved prediction accuracy to 80.9%+/-2.2%.<h4>Conclusion</h4>Adipose gene expression profiling prior to the consumption of a low-fat diet is able to differentiate responders from non-responders as well as serve as a weak predictor of subjects destined to lose weight. While the degree of prediction accuracy currently achieved with a gene expression snapshot is perhaps insufficient for clinical use, this work reveals that the comprehensive molecular signature of adipose tissue paves the way for the future of personalized nutrition.
format article
author David M Mutch
M Ramzi Temanni
Corneliu Henegar
Florence Combes
Florence Combes
Véronique Pelloux
Claus Holst
Thorkild I A Sørensen
Arne Astrup
J Alfredo Martinez
Wim H M Saris
Nathalie Viguerie
Dominique Langin
Jean-Daniel Zucker
Karine Clément
author_facet David M Mutch
M Ramzi Temanni
Corneliu Henegar
Florence Combes
Florence Combes
Véronique Pelloux
Claus Holst
Thorkild I A Sørensen
Arne Astrup
J Alfredo Martinez
Wim H M Saris
Nathalie Viguerie
Dominique Langin
Jean-Daniel Zucker
Karine Clément
author_sort David M Mutch
title Adipose gene expression prior to weight loss can differentiate and weakly predict dietary responders.
title_short Adipose gene expression prior to weight loss can differentiate and weakly predict dietary responders.
title_full Adipose gene expression prior to weight loss can differentiate and weakly predict dietary responders.
title_fullStr Adipose gene expression prior to weight loss can differentiate and weakly predict dietary responders.
title_full_unstemmed Adipose gene expression prior to weight loss can differentiate and weakly predict dietary responders.
title_sort adipose gene expression prior to weight loss can differentiate and weakly predict dietary responders.
publisher Public Library of Science (PLoS)
publishDate 2007
url https://doaj.org/article/d13e11834ce94b149fe08fae7010428b
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