Gastrointestinal microbiota composition predicts peripheral inflammatory state during treatment of human tuberculosis

Antibiotic therapy can lead to pathogen clearance, but also to alterations in the gut microbiota and systemic immune responses. Here, the authors analyze data from patients with tuberculosis and healthy subjects to show that pathogen clearance and gut microbiota alterations are independently associa...

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Autores principales:	Matthew F. Wipperman, Shakti K. Bhattarai, Charles Kyriakos Vorkas, Venkata Suhas Maringati, Ying Taur, Laurent Mathurin, Katherine McAulay, Stalz Charles Vilbrun, Daphie Francois, James Bean, Kathleen F. Walsh, Carl Nathan, Daniel W. Fitzgerald, Michael S. Glickman, Vanni Bucci
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d1412789c68649e5804527b92e439bff
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spelling	oai:doaj.org-article:d1412789c68649e5804527b92e439bff2021-12-02T12:11:39ZGastrointestinal microbiota composition predicts peripheral inflammatory state during treatment of human tuberculosis10.1038/s41467-021-21475-y2041-1723https://doaj.org/article/d1412789c68649e5804527b92e439bff2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21475-yhttps://doaj.org/toc/2041-1723Antibiotic therapy can lead to pathogen clearance, but also to alterations in the gut microbiota and systemic immune responses. Here, the authors analyze data from patients with tuberculosis and healthy subjects to show that pathogen clearance and gut microbiota alterations are independently associated with antibiotic-induced changes of the inflammatory response of active tuberculosis.Matthew F. WippermanShakti K. BhattaraiCharles Kyriakos VorkasVenkata Suhas MaringatiYing TaurLaurent MathurinKatherine McAulayStalz Charles VilbrunDaphie FrancoisJames BeanKathleen F. WalshCarl NathanDaniel W. FitzgeraldMichael S. GlickmanVanni BucciNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthew F. Wipperman Shakti K. Bhattarai Charles Kyriakos Vorkas Venkata Suhas Maringati Ying Taur Laurent Mathurin Katherine McAulay Stalz Charles Vilbrun Daphie Francois James Bean Kathleen F. Walsh Carl Nathan Daniel W. Fitzgerald Michael S. Glickman Vanni Bucci Gastrointestinal microbiota composition predicts peripheral inflammatory state during treatment of human tuberculosis
description	Antibiotic therapy can lead to pathogen clearance, but also to alterations in the gut microbiota and systemic immune responses. Here, the authors analyze data from patients with tuberculosis and healthy subjects to show that pathogen clearance and gut microbiota alterations are independently associated with antibiotic-induced changes of the inflammatory response of active tuberculosis.
format	article
author	Matthew F. Wipperman Shakti K. Bhattarai Charles Kyriakos Vorkas Venkata Suhas Maringati Ying Taur Laurent Mathurin Katherine McAulay Stalz Charles Vilbrun Daphie Francois James Bean Kathleen F. Walsh Carl Nathan Daniel W. Fitzgerald Michael S. Glickman Vanni Bucci
author_facet	Matthew F. Wipperman Shakti K. Bhattarai Charles Kyriakos Vorkas Venkata Suhas Maringati Ying Taur Laurent Mathurin Katherine McAulay Stalz Charles Vilbrun Daphie Francois James Bean Kathleen F. Walsh Carl Nathan Daniel W. Fitzgerald Michael S. Glickman Vanni Bucci
author_sort	Matthew F. Wipperman
title	Gastrointestinal microbiota composition predicts peripheral inflammatory state during treatment of human tuberculosis
title_short	Gastrointestinal microbiota composition predicts peripheral inflammatory state during treatment of human tuberculosis
title_full	Gastrointestinal microbiota composition predicts peripheral inflammatory state during treatment of human tuberculosis
title_fullStr	Gastrointestinal microbiota composition predicts peripheral inflammatory state during treatment of human tuberculosis
title_full_unstemmed	Gastrointestinal microbiota composition predicts peripheral inflammatory state during treatment of human tuberculosis
title_sort	gastrointestinal microbiota composition predicts peripheral inflammatory state during treatment of human tuberculosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d1412789c68649e5804527b92e439bff
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Gastrointestinal microbiota composition predicts peripheral inflammatory state during treatment of human tuberculosis

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