Sorting through the wealth of options: comparative evaluation of two ultraviolet disinfection systems.

<h4>Background</h4>Environmental surfaces play an important role in the transmission of healthcare-associated pathogens. Because environmental cleaning is often suboptimal, there is a growing demand for safe, rapid, and automated disinfection technologies, which has lead to a wealth of n...

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Autores principales:	Michelle M Nerandzic, Christopher W Fisher, Curtis J Donskey
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d1412eba1e5a4aa29cecd0ae7774987c
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spelling	oai:doaj.org-article:d1412eba1e5a4aa29cecd0ae7774987c2021-11-25T05:59:42ZSorting through the wealth of options: comparative evaluation of two ultraviolet disinfection systems.1932-620310.1371/journal.pone.0107444https://doaj.org/article/d1412eba1e5a4aa29cecd0ae7774987c2014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0107444https://doaj.org/toc/1932-6203<h4>Background</h4>Environmental surfaces play an important role in the transmission of healthcare-associated pathogens. Because environmental cleaning is often suboptimal, there is a growing demand for safe, rapid, and automated disinfection technologies, which has lead to a wealth of novel disinfection options available on the market. Specifically, automated ultraviolet-C (UV-C) devices have grown in number due to the documented efficacy of UV-C for reducing healthcare-acquired pathogens in hospital rooms. Here, we assessed and compared the impact of pathogen concentration, organic load, distance, and radiant dose on the killing efficacy of two analogous UV-C devices.<h4>Principal findings</h4>The devices performed equivalently for each impact factor assessed. Irradiation delivered for 41 minutes at 4 feet from the devices consistently reduced C. difficile spores by ∼ 3 log10CFU/cm2, MRSA by>4 log10CFU/cm2, and VRE by >5 log10CFU/cm2. Pathogen concentration did not significantly impact the killing efficacy of the devices. However, both a light and heavy organic load had a significant negative impacted on the killing efficacy of the devices. Additionally, increasing the distance to 10 feet from the devices reduced the killing efficacy to ≤3 log10CFU/cm2 for MRSA and VRE and <2 log10CFU/cm2 for C.difficile spores. Delivery of reduced timed doses of irradiation particularly impacted the ability of the devices to kill C. difficile spores. MRSA and VRE were reduced by >3 log10CFU/cm2 after only 10 minutes of irradiation, while C. difficile spores required 40 minutes of irradiation to achieve a similar reduction.<h4>Conclusions</h4>The UV-C devices were equally effective for killing C. difficile spores, MRSA, and VRE. While neither device would be recommended as a stand-alone disinfection procedure, either device would be a useful adjunctive measure to routine cleaning in healthcare facilities.Michelle M NerandzicChristopher W FisherCurtis J DonskeyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 9, p e107444 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michelle M Nerandzic Christopher W Fisher Curtis J Donskey Sorting through the wealth of options: comparative evaluation of two ultraviolet disinfection systems.
description	<h4>Background</h4>Environmental surfaces play an important role in the transmission of healthcare-associated pathogens. Because environmental cleaning is often suboptimal, there is a growing demand for safe, rapid, and automated disinfection technologies, which has lead to a wealth of novel disinfection options available on the market. Specifically, automated ultraviolet-C (UV-C) devices have grown in number due to the documented efficacy of UV-C for reducing healthcare-acquired pathogens in hospital rooms. Here, we assessed and compared the impact of pathogen concentration, organic load, distance, and radiant dose on the killing efficacy of two analogous UV-C devices.<h4>Principal findings</h4>The devices performed equivalently for each impact factor assessed. Irradiation delivered for 41 minutes at 4 feet from the devices consistently reduced C. difficile spores by ∼ 3 log10CFU/cm2, MRSA by>4 log10CFU/cm2, and VRE by >5 log10CFU/cm2. Pathogen concentration did not significantly impact the killing efficacy of the devices. However, both a light and heavy organic load had a significant negative impacted on the killing efficacy of the devices. Additionally, increasing the distance to 10 feet from the devices reduced the killing efficacy to ≤3 log10CFU/cm2 for MRSA and VRE and <2 log10CFU/cm2 for C.difficile spores. Delivery of reduced timed doses of irradiation particularly impacted the ability of the devices to kill C. difficile spores. MRSA and VRE were reduced by >3 log10CFU/cm2 after only 10 minutes of irradiation, while C. difficile spores required 40 minutes of irradiation to achieve a similar reduction.<h4>Conclusions</h4>The UV-C devices were equally effective for killing C. difficile spores, MRSA, and VRE. While neither device would be recommended as a stand-alone disinfection procedure, either device would be a useful adjunctive measure to routine cleaning in healthcare facilities.
format	article
author	Michelle M Nerandzic Christopher W Fisher Curtis J Donskey
author_facet	Michelle M Nerandzic Christopher W Fisher Curtis J Donskey
author_sort	Michelle M Nerandzic
title	Sorting through the wealth of options: comparative evaluation of two ultraviolet disinfection systems.
title_short	Sorting through the wealth of options: comparative evaluation of two ultraviolet disinfection systems.
title_full	Sorting through the wealth of options: comparative evaluation of two ultraviolet disinfection systems.
title_fullStr	Sorting through the wealth of options: comparative evaluation of two ultraviolet disinfection systems.
title_full_unstemmed	Sorting through the wealth of options: comparative evaluation of two ultraviolet disinfection systems.
title_sort	sorting through the wealth of options: comparative evaluation of two ultraviolet disinfection systems.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/d1412eba1e5a4aa29cecd0ae7774987c
work_keys_str_mv	AT michellemnerandzic sortingthroughthewealthofoptionscomparativeevaluationoftwoultravioletdisinfectionsystems AT christopherwfisher sortingthroughthewealthofoptionscomparativeevaluationoftwoultravioletdisinfectionsystems AT curtisjdonskey sortingthroughthewealthofoptionscomparativeevaluationoftwoultravioletdisinfectionsystems
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Sorting through the wealth of options: comparative evaluation of two ultraviolet disinfection systems.

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