Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases

In addition to playing a pivotal role in cellular energetics and biosynthesis, mitochondrial components are key operators in the regulation of cell death. In addition to apoptosis, necrosis is a highly relevant form of programmed liver cell death. Differential activation of specific forms of program...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Qingfei Chu, Xinyu Gu, Qiuxian Zheng, Jing Wang, Haihong Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
Acceso en línea:	https://doaj.org/article/d14341aa0e7f413fa4c26f9dc344c400
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d14341aa0e7f413fa4c26f9dc344c400
record_format	dspace
spelling	oai:doaj.org-article:d14341aa0e7f413fa4c26f9dc344c4002021-11-22T01:09:35ZMitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases2210-718510.1155/2021/8900122https://doaj.org/article/d14341aa0e7f413fa4c26f9dc344c4002021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/8900122https://doaj.org/toc/2210-7185In addition to playing a pivotal role in cellular energetics and biosynthesis, mitochondrial components are key operators in the regulation of cell death. In addition to apoptosis, necrosis is a highly relevant form of programmed liver cell death. Differential activation of specific forms of programmed cell death may not only affect the outcome of liver disease but may also provide new opportunities for therapeutic intervention. This review describes the role of mitochondria in cell death and the mechanism that leads to chronic liver hepatitis and liver cirrhosis. We focus on mitochondrial-driven apoptosis and current knowledge of necroptosis and discuss therapeutic strategies for targeting mitochondrial-mediated cell death in liver diseases.Qingfei ChuXinyu GuQiuxian ZhengJing WangHaihong ZhuHindawi LimitedarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282CytologyQH573-671ENAnalytical Cellular Pathology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671 Qingfei Chu Xinyu Gu Qiuxian Zheng Jing Wang Haihong Zhu Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases
description	In addition to playing a pivotal role in cellular energetics and biosynthesis, mitochondrial components are key operators in the regulation of cell death. In addition to apoptosis, necrosis is a highly relevant form of programmed liver cell death. Differential activation of specific forms of programmed cell death may not only affect the outcome of liver disease but may also provide new opportunities for therapeutic intervention. This review describes the role of mitochondria in cell death and the mechanism that leads to chronic liver hepatitis and liver cirrhosis. We focus on mitochondrial-driven apoptosis and current knowledge of necroptosis and discuss therapeutic strategies for targeting mitochondrial-mediated cell death in liver diseases.
format	article
author	Qingfei Chu Xinyu Gu Qiuxian Zheng Jing Wang Haihong Zhu
author_facet	Qingfei Chu Xinyu Gu Qiuxian Zheng Jing Wang Haihong Zhu
author_sort	Qingfei Chu
title	Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases
title_short	Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases
title_full	Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases
title_fullStr	Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases
title_full_unstemmed	Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases
title_sort	mitochondrial mechanisms of apoptosis and necroptosis in liver diseases
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/d14341aa0e7f413fa4c26f9dc344c400
work_keys_str_mv	AT qingfeichu mitochondrialmechanismsofapoptosisandnecroptosisinliverdiseases AT xinyugu mitochondrialmechanismsofapoptosisandnecroptosisinliverdiseases AT qiuxianzheng mitochondrialmechanismsofapoptosisandnecroptosisinliverdiseases AT jingwang mitochondrialmechanismsofapoptosisandnecroptosisinliverdiseases AT haihongzhu mitochondrialmechanismsofapoptosisandnecroptosisinliverdiseases
_version_	1718418427462287360

Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases

Ejemplares similares