Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases
In addition to playing a pivotal role in cellular energetics and biosynthesis, mitochondrial components are key operators in the regulation of cell death. In addition to apoptosis, necrosis is a highly relevant form of programmed liver cell death. Differential activation of specific forms of program...
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Hindawi Limited
2021
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oai:doaj.org-article:d14341aa0e7f413fa4c26f9dc344c4002021-11-22T01:09:35ZMitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases2210-718510.1155/2021/8900122https://doaj.org/article/d14341aa0e7f413fa4c26f9dc344c4002021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/8900122https://doaj.org/toc/2210-7185In addition to playing a pivotal role in cellular energetics and biosynthesis, mitochondrial components are key operators in the regulation of cell death. In addition to apoptosis, necrosis is a highly relevant form of programmed liver cell death. Differential activation of specific forms of programmed cell death may not only affect the outcome of liver disease but may also provide new opportunities for therapeutic intervention. This review describes the role of mitochondria in cell death and the mechanism that leads to chronic liver hepatitis and liver cirrhosis. We focus on mitochondrial-driven apoptosis and current knowledge of necroptosis and discuss therapeutic strategies for targeting mitochondrial-mediated cell death in liver diseases.Qingfei ChuXinyu GuQiuxian ZhengJing WangHaihong ZhuHindawi LimitedarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282CytologyQH573-671ENAnalytical Cellular Pathology, Vol 2021 (2021) |
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671 |
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671 Qingfei Chu Xinyu Gu Qiuxian Zheng Jing Wang Haihong Zhu Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases |
description |
In addition to playing a pivotal role in cellular energetics and biosynthesis, mitochondrial components are key operators in the regulation of cell death. In addition to apoptosis, necrosis is a highly relevant form of programmed liver cell death. Differential activation of specific forms of programmed cell death may not only affect the outcome of liver disease but may also provide new opportunities for therapeutic intervention. This review describes the role of mitochondria in cell death and the mechanism that leads to chronic liver hepatitis and liver cirrhosis. We focus on mitochondrial-driven apoptosis and current knowledge of necroptosis and discuss therapeutic strategies for targeting mitochondrial-mediated cell death in liver diseases. |
format |
article |
author |
Qingfei Chu Xinyu Gu Qiuxian Zheng Jing Wang Haihong Zhu |
author_facet |
Qingfei Chu Xinyu Gu Qiuxian Zheng Jing Wang Haihong Zhu |
author_sort |
Qingfei Chu |
title |
Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases |
title_short |
Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases |
title_full |
Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases |
title_fullStr |
Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases |
title_full_unstemmed |
Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases |
title_sort |
mitochondrial mechanisms of apoptosis and necroptosis in liver diseases |
publisher |
Hindawi Limited |
publishDate |
2021 |
url |
https://doaj.org/article/d14341aa0e7f413fa4c26f9dc344c400 |
work_keys_str_mv |
AT qingfeichu mitochondrialmechanismsofapoptosisandnecroptosisinliverdiseases AT xinyugu mitochondrialmechanismsofapoptosisandnecroptosisinliverdiseases AT qiuxianzheng mitochondrialmechanismsofapoptosisandnecroptosisinliverdiseases AT jingwang mitochondrialmechanismsofapoptosisandnecroptosisinliverdiseases AT haihongzhu mitochondrialmechanismsofapoptosisandnecroptosisinliverdiseases |
_version_ |
1718418427462287360 |