Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases

In addition to playing a pivotal role in cellular energetics and biosynthesis, mitochondrial components are key operators in the regulation of cell death. In addition to apoptosis, necrosis is a highly relevant form of programmed liver cell death. Differential activation of specific forms of program...

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Autores principales: Qingfei Chu, Xinyu Gu, Qiuxian Zheng, Jing Wang, Haihong Zhu
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Lenguaje:EN
Publicado: Hindawi Limited 2021
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Acceso en línea:https://doaj.org/article/d14341aa0e7f413fa4c26f9dc344c400
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spelling oai:doaj.org-article:d14341aa0e7f413fa4c26f9dc344c4002021-11-22T01:09:35ZMitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases2210-718510.1155/2021/8900122https://doaj.org/article/d14341aa0e7f413fa4c26f9dc344c4002021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/8900122https://doaj.org/toc/2210-7185In addition to playing a pivotal role in cellular energetics and biosynthesis, mitochondrial components are key operators in the regulation of cell death. In addition to apoptosis, necrosis is a highly relevant form of programmed liver cell death. Differential activation of specific forms of programmed cell death may not only affect the outcome of liver disease but may also provide new opportunities for therapeutic intervention. This review describes the role of mitochondria in cell death and the mechanism that leads to chronic liver hepatitis and liver cirrhosis. We focus on mitochondrial-driven apoptosis and current knowledge of necroptosis and discuss therapeutic strategies for targeting mitochondrial-mediated cell death in liver diseases.Qingfei ChuXinyu GuQiuxian ZhengJing WangHaihong ZhuHindawi LimitedarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282CytologyQH573-671ENAnalytical Cellular Pathology, Vol 2021 (2021)
institution DOAJ
collection DOAJ
language EN
topic Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Cytology
QH573-671
spellingShingle Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Cytology
QH573-671
Qingfei Chu
Xinyu Gu
Qiuxian Zheng
Jing Wang
Haihong Zhu
Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases
description In addition to playing a pivotal role in cellular energetics and biosynthesis, mitochondrial components are key operators in the regulation of cell death. In addition to apoptosis, necrosis is a highly relevant form of programmed liver cell death. Differential activation of specific forms of programmed cell death may not only affect the outcome of liver disease but may also provide new opportunities for therapeutic intervention. This review describes the role of mitochondria in cell death and the mechanism that leads to chronic liver hepatitis and liver cirrhosis. We focus on mitochondrial-driven apoptosis and current knowledge of necroptosis and discuss therapeutic strategies for targeting mitochondrial-mediated cell death in liver diseases.
format article
author Qingfei Chu
Xinyu Gu
Qiuxian Zheng
Jing Wang
Haihong Zhu
author_facet Qingfei Chu
Xinyu Gu
Qiuxian Zheng
Jing Wang
Haihong Zhu
author_sort Qingfei Chu
title Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases
title_short Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases
title_full Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases
title_fullStr Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases
title_full_unstemmed Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases
title_sort mitochondrial mechanisms of apoptosis and necroptosis in liver diseases
publisher Hindawi Limited
publishDate 2021
url https://doaj.org/article/d14341aa0e7f413fa4c26f9dc344c400
work_keys_str_mv AT qingfeichu mitochondrialmechanismsofapoptosisandnecroptosisinliverdiseases
AT xinyugu mitochondrialmechanismsofapoptosisandnecroptosisinliverdiseases
AT qiuxianzheng mitochondrialmechanismsofapoptosisandnecroptosisinliverdiseases
AT jingwang mitochondrialmechanismsofapoptosisandnecroptosisinliverdiseases
AT haihongzhu mitochondrialmechanismsofapoptosisandnecroptosisinliverdiseases
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