Investigation of water bonding status of normal and psoriatic skin in vivo using diffuse reflectance spectroscopy

Abstract Psoriasis affects more than 125 million people worldwide, and the diagnosis and treatment efficacy evaluation of the disease mainly rely on clinical assessments that could be subjective. Our previous study showed that the skin erythema level could be quantified using diffuse reflectance spe...

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Autores principales:	Chao-Chun Yang, Yun-Yo Yen, Chao-Kai Hsu, Nan-Yu Cheng, Shih-Yu Tzeng, Shih-Jay Chou, Jun-Ming Chang, Sheng-Hao Tseng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d148525855a040388407fc1d310d7307
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spelling	oai:doaj.org-article:d148525855a040388407fc1d310d73072021-12-02T17:39:20ZInvestigation of water bonding status of normal and psoriatic skin in vivo using diffuse reflectance spectroscopy10.1038/s41598-021-88530-y2045-2322https://doaj.org/article/d148525855a040388407fc1d310d73072021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88530-yhttps://doaj.org/toc/2045-2322Abstract Psoriasis affects more than 125 million people worldwide, and the diagnosis and treatment efficacy evaluation of the disease mainly rely on clinical assessments that could be subjective. Our previous study showed that the skin erythema level could be quantified using diffuse reflectance spectroscopy (DRS), and the hemoglobin concentration of most psoriatic lesion was higher than that of its adjacent uninvolved skin. While the compromised epidermal barrier function has been taken as the major cause of clinical manifestation of skin dryness and inflammation of psoriasis, very few methods can be used to effectively evaluate this function. In this study, we investigate the near infrared spectroscopic features of psoriatic (n = 21) and normal (n = 21) skin that could link to the epidermal barrier function. From the DRS measurements, it was found that the water bonding status and light scattering properties of psoriasis are significantly different from those of uninvolved or normal skin. The connection between these parameters to the epidermal barrier function and morphology will be discussed. Our results suggest that objective evaluation of epidermal barrier function of psoriasis could be achieved using a simple DRS system.Chao-Chun YangYun-Yo YenChao-Kai HsuNan-Yu ChengShih-Yu TzengShih-Jay ChouJun-Ming ChangSheng-Hao TsengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chao-Chun Yang Yun-Yo Yen Chao-Kai Hsu Nan-Yu Cheng Shih-Yu Tzeng Shih-Jay Chou Jun-Ming Chang Sheng-Hao Tseng Investigation of water bonding status of normal and psoriatic skin in vivo using diffuse reflectance spectroscopy
description	Abstract Psoriasis affects more than 125 million people worldwide, and the diagnosis and treatment efficacy evaluation of the disease mainly rely on clinical assessments that could be subjective. Our previous study showed that the skin erythema level could be quantified using diffuse reflectance spectroscopy (DRS), and the hemoglobin concentration of most psoriatic lesion was higher than that of its adjacent uninvolved skin. While the compromised epidermal barrier function has been taken as the major cause of clinical manifestation of skin dryness and inflammation of psoriasis, very few methods can be used to effectively evaluate this function. In this study, we investigate the near infrared spectroscopic features of psoriatic (n = 21) and normal (n = 21) skin that could link to the epidermal barrier function. From the DRS measurements, it was found that the water bonding status and light scattering properties of psoriasis are significantly different from those of uninvolved or normal skin. The connection between these parameters to the epidermal barrier function and morphology will be discussed. Our results suggest that objective evaluation of epidermal barrier function of psoriasis could be achieved using a simple DRS system.
format	article
author	Chao-Chun Yang Yun-Yo Yen Chao-Kai Hsu Nan-Yu Cheng Shih-Yu Tzeng Shih-Jay Chou Jun-Ming Chang Sheng-Hao Tseng
author_facet	Chao-Chun Yang Yun-Yo Yen Chao-Kai Hsu Nan-Yu Cheng Shih-Yu Tzeng Shih-Jay Chou Jun-Ming Chang Sheng-Hao Tseng
author_sort	Chao-Chun Yang
title	Investigation of water bonding status of normal and psoriatic skin in vivo using diffuse reflectance spectroscopy
title_short	Investigation of water bonding status of normal and psoriatic skin in vivo using diffuse reflectance spectroscopy
title_full	Investigation of water bonding status of normal and psoriatic skin in vivo using diffuse reflectance spectroscopy
title_fullStr	Investigation of water bonding status of normal and psoriatic skin in vivo using diffuse reflectance spectroscopy
title_full_unstemmed	Investigation of water bonding status of normal and psoriatic skin in vivo using diffuse reflectance spectroscopy
title_sort	investigation of water bonding status of normal and psoriatic skin in vivo using diffuse reflectance spectroscopy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d148525855a040388407fc1d310d7307
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_version_	1718379849617244160

Investigation of water bonding status of normal and psoriatic skin in vivo using diffuse reflectance spectroscopy

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