Dose comparison of ultrasonic transdermal insulin delivery to subcutaneous insulin injection

Eun-Joo Park1, Jeff Dodds2, Nadine Barrie Smith31Department of Bioengineering, 2Animal Resource Program, 3Graduate Program in Acoustics, The Pennsylvania State University, University Park, PA, USAAbstract: Prior studies have demonstrated the effectiveness of noninvasive transdermal insulin delivery...

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Autores principales:	Eun-Joo Park, Jeff Dodds, Nadine Barrie Smith
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d1500d877ff442eaaf2d6de47a30f77d
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spelling	oai:doaj.org-article:d1500d877ff442eaaf2d6de47a30f77d2021-12-02T00:43:21ZDose comparison of ultrasonic transdermal insulin delivery to subcutaneous insulin injection1176-91141178-2013https://doaj.org/article/d1500d877ff442eaaf2d6de47a30f77d2008-10-01T00:00:00Zhttp://www.dovepress.com/dose-comparison-of-ultrasonic-transdermal-insulin-delivery-to-subcutan-a2443https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Eun-Joo Park1, Jeff Dodds2, Nadine Barrie Smith31Department of Bioengineering, 2Animal Resource Program, 3Graduate Program in Acoustics, The Pennsylvania State University, University Park, PA, USAAbstract: Prior studies have demonstrated the effectiveness of noninvasive transdermal insulin delivery using a cymbal transducer array. In this study the physiologic response to ultrasound mediated transdermal insulin delivery is compared to that of subcutaneously administered insulin. Anesthetized rats (350&ndash;550 g) were divided into four groups of four animals; one group representing ultrasound mediated insulin delivery and three representing subcutaneously administered insulin (0.15, 0.20, and 0.25 U/kg). The cymbal array was operated for 60 minutes at 20 kHz with 100 mW/cm2 spatial-peak temporal-peak intensity and a 20% duty cycle. The blood glucose level was determined at the beginning of the experiment and, following insulin administration, every 15 minutes for 90 minutes for both the ultrasound and injection groups. The change in blood glucose from baseline was compared between groups. When administered by subcutaneous injection at insulin doses of 0.15 and 0.20 U/kg, there was little change in the blood glucose levels over the 90 minute experiment. Following subcutaneous administration of insulin at a dose of 0.25 U/kg, blood glucose decreased by 190 &plusmn; 96 mg/dl (mean &plusmn; SD) at 90 minutes. The change in blood glucose following ultrasound mediated insulin delivery was &minus;262 &plusmn; 40 mg/dl at 90 minutes. As expected, the magnitude of change in blood glucose between the three injection groups was dependant on the dose of insulin administered. The change in blood glucose in the ultrasound group was greater than that observed in the injection groups suggesting that a higher effective dose of insulin was delivered.Keywords: ultrasound, intensity, drug delivery, insulin, injections Eun-Joo ParkJeff DoddsNadine Barrie SmithDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2008, Iss Issue 3, Pp 335-341 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Eun-Joo Park Jeff Dodds Nadine Barrie Smith Dose comparison of ultrasonic transdermal insulin delivery to subcutaneous insulin injection
description	Eun-Joo Park1, Jeff Dodds2, Nadine Barrie Smith31Department of Bioengineering, 2Animal Resource Program, 3Graduate Program in Acoustics, The Pennsylvania State University, University Park, PA, USAAbstract: Prior studies have demonstrated the effectiveness of noninvasive transdermal insulin delivery using a cymbal transducer array. In this study the physiologic response to ultrasound mediated transdermal insulin delivery is compared to that of subcutaneously administered insulin. Anesthetized rats (350&ndash;550 g) were divided into four groups of four animals; one group representing ultrasound mediated insulin delivery and three representing subcutaneously administered insulin (0.15, 0.20, and 0.25 U/kg). The cymbal array was operated for 60 minutes at 20 kHz with 100 mW/cm2 spatial-peak temporal-peak intensity and a 20% duty cycle. The blood glucose level was determined at the beginning of the experiment and, following insulin administration, every 15 minutes for 90 minutes for both the ultrasound and injection groups. The change in blood glucose from baseline was compared between groups. When administered by subcutaneous injection at insulin doses of 0.15 and 0.20 U/kg, there was little change in the blood glucose levels over the 90 minute experiment. Following subcutaneous administration of insulin at a dose of 0.25 U/kg, blood glucose decreased by 190 &plusmn; 96 mg/dl (mean &plusmn; SD) at 90 minutes. The change in blood glucose following ultrasound mediated insulin delivery was &minus;262 &plusmn; 40 mg/dl at 90 minutes. As expected, the magnitude of change in blood glucose between the three injection groups was dependant on the dose of insulin administered. The change in blood glucose in the ultrasound group was greater than that observed in the injection groups suggesting that a higher effective dose of insulin was delivered.Keywords: ultrasound, intensity, drug delivery, insulin, injections
format	article
author	Eun-Joo Park Jeff Dodds Nadine Barrie Smith
author_facet	Eun-Joo Park Jeff Dodds Nadine Barrie Smith
author_sort	Eun-Joo Park
title	Dose comparison of ultrasonic transdermal insulin delivery to subcutaneous insulin injection
title_short	Dose comparison of ultrasonic transdermal insulin delivery to subcutaneous insulin injection
title_full	Dose comparison of ultrasonic transdermal insulin delivery to subcutaneous insulin injection
title_fullStr	Dose comparison of ultrasonic transdermal insulin delivery to subcutaneous insulin injection
title_full_unstemmed	Dose comparison of ultrasonic transdermal insulin delivery to subcutaneous insulin injection
title_sort	dose comparison of ultrasonic transdermal insulin delivery to subcutaneous insulin injection
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/d1500d877ff442eaaf2d6de47a30f77d
work_keys_str_mv	AT eunjoopark dosecomparisonofultrasonictransdermalinsulindeliverytosubcutaneousinsulininjection AT jeffdodds dosecomparisonofultrasonictransdermalinsulindeliverytosubcutaneousinsulininjection AT nadinebarriesmith dosecomparisonofultrasonictransdermalinsulindeliverytosubcutaneousinsulininjection
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Dose comparison of ultrasonic transdermal insulin delivery to subcutaneous insulin injection

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