Impact of the COVID-19 pandemic on symptoms of anxiety and depression and health-related quality of life in older patients with chronic kidney disease

Abstract Background Older patients with advanced chronic kidney disease are at increased risk for a severe course of the coronavirus disease-2019 (COVID-19) and vulnerable to mental health problems. We aimed to investigate prevalence and associated patient (demographic and clinical) characteristics...

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Autores principales:	C. G. N. Voorend, M. van Oevelen, M. Nieberg, Y. Meuleman, C. F. M. Franssen, H. Joosten, N. C. Berkhout-Byrne, A. C. Abrahams, S. P. Mooijaart, W. J. W. Bos, M. van Buren, on behalf of the POLDER investigators
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Aged Chronic kidney diseases Coronavirus disease-2019 (COVID-19) pandemic Mental health Quality of life Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/d15689734b4e43c9bf1461b8b8d0a7f4
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spelling	oai:doaj.org-article:d15689734b4e43c9bf1461b8b8d0a7f42021-11-21T12:07:19ZImpact of the COVID-19 pandemic on symptoms of anxiety and depression and health-related quality of life in older patients with chronic kidney disease10.1186/s12877-021-02593-01471-2318https://doaj.org/article/d15689734b4e43c9bf1461b8b8d0a7f42021-11-01T00:00:00Zhttps://doi.org/10.1186/s12877-021-02593-0https://doaj.org/toc/1471-2318Abstract Background Older patients with advanced chronic kidney disease are at increased risk for a severe course of the coronavirus disease-2019 (COVID-19) and vulnerable to mental health problems. We aimed to investigate prevalence and associated patient (demographic and clinical) characteristics of mental wellbeing (health-related quality of life [HRQoL] and symptoms of depression and anxiety) before and during the COVID-19 pandemic in older patients with advanced chronic kidney disease. Methods An ongoing Dutch multicentre prospective cohort study enrols patients of ≥70 years with an eGFR < 20 mL/min/1.73m2 from October 2018 onward. With additional questionnaires during the pandemic (May–June 2020), disease-related concerns about COVID-19 and general anxiety symptoms were assessed cross-sectionally, and depressive symptoms, HRQoL, and emotional symptoms longitudinally. Results The 82 included patients had a median age of 77.5 years (interquartile range 73.9–82.1), 77% were male and none had tested positive for COVID-19. Cross-sectionally, 67% of the patients reported to be more anxious about COVID-19 because of their kidney disease, and 43% of the patients stated that their quality of life was reduced due to the COVID-19 pandemic. Compared to pre-COVID-19, the presence of depressive symptoms had increased (11 to 22%; p = .022) and physical HRQoL declined (M = 40.4, SD = 10.1 to M = 36.1, SD = 10.4; p < .001), particularly in males. Mental HRQoL (M = 50.3, SD = 9.6 to M = 50.4, SD = 9.9; p = .913) and emotional symptoms remained similar. Conclusions Older patients with advanced chronic kidney disease suffered from disease-related anxiety about COVID-19, increased depressive symptoms and reduced physical HRQoL during the COVID-19 pandemic. The impact of the pandemic on this vulnerable patient group extends beyond increased mortality risk, and awareness of mental wellbeing is important. Trial registration The study is registered at the Netherlands Trial Register (NTR), trial number NL7104. Date of registration: 06-06-2018.C. G. N. VoorendM. van OevelenM. NiebergY. MeulemanC. F. M. FranssenH. JoostenN. C. Berkhout-ByrneA. C. AbrahamsS. P. MooijaartW. J. W. BosM. van Burenon behalf of the POLDER investigatorsBMCarticleAgedChronic kidney diseasesCoronavirus disease-2019 (COVID-19) pandemicMental healthQuality of lifeGeriatricsRC952-954.6ENBMC Geriatrics, Vol 21, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Aged Chronic kidney diseases Coronavirus disease-2019 (COVID-19) pandemic Mental health Quality of life Geriatrics RC952-954.6
spellingShingle	Aged Chronic kidney diseases Coronavirus disease-2019 (COVID-19) pandemic Mental health Quality of life Geriatrics RC952-954.6 C. G. N. Voorend M. van Oevelen M. Nieberg Y. Meuleman C. F. M. Franssen H. Joosten N. C. Berkhout-Byrne A. C. Abrahams S. P. Mooijaart W. J. W. Bos M. van Buren on behalf of the POLDER investigators Impact of the COVID-19 pandemic on symptoms of anxiety and depression and health-related quality of life in older patients with chronic kidney disease
description	Abstract Background Older patients with advanced chronic kidney disease are at increased risk for a severe course of the coronavirus disease-2019 (COVID-19) and vulnerable to mental health problems. We aimed to investigate prevalence and associated patient (demographic and clinical) characteristics of mental wellbeing (health-related quality of life [HRQoL] and symptoms of depression and anxiety) before and during the COVID-19 pandemic in older patients with advanced chronic kidney disease. Methods An ongoing Dutch multicentre prospective cohort study enrols patients of ≥70 years with an eGFR < 20 mL/min/1.73m2 from October 2018 onward. With additional questionnaires during the pandemic (May–June 2020), disease-related concerns about COVID-19 and general anxiety symptoms were assessed cross-sectionally, and depressive symptoms, HRQoL, and emotional symptoms longitudinally. Results The 82 included patients had a median age of 77.5 years (interquartile range 73.9–82.1), 77% were male and none had tested positive for COVID-19. Cross-sectionally, 67% of the patients reported to be more anxious about COVID-19 because of their kidney disease, and 43% of the patients stated that their quality of life was reduced due to the COVID-19 pandemic. Compared to pre-COVID-19, the presence of depressive symptoms had increased (11 to 22%; p = .022) and physical HRQoL declined (M = 40.4, SD = 10.1 to M = 36.1, SD = 10.4; p < .001), particularly in males. Mental HRQoL (M = 50.3, SD = 9.6 to M = 50.4, SD = 9.9; p = .913) and emotional symptoms remained similar. Conclusions Older patients with advanced chronic kidney disease suffered from disease-related anxiety about COVID-19, increased depressive symptoms and reduced physical HRQoL during the COVID-19 pandemic. The impact of the pandemic on this vulnerable patient group extends beyond increased mortality risk, and awareness of mental wellbeing is important. Trial registration The study is registered at the Netherlands Trial Register (NTR), trial number NL7104. Date of registration: 06-06-2018.
format	article
author	C. G. N. Voorend M. van Oevelen M. Nieberg Y. Meuleman C. F. M. Franssen H. Joosten N. C. Berkhout-Byrne A. C. Abrahams S. P. Mooijaart W. J. W. Bos M. van Buren on behalf of the POLDER investigators
author_facet	C. G. N. Voorend M. van Oevelen M. Nieberg Y. Meuleman C. F. M. Franssen H. Joosten N. C. Berkhout-Byrne A. C. Abrahams S. P. Mooijaart W. J. W. Bos M. van Buren on behalf of the POLDER investigators
author_sort	C. G. N. Voorend
title	Impact of the COVID-19 pandemic on symptoms of anxiety and depression and health-related quality of life in older patients with chronic kidney disease
title_short	Impact of the COVID-19 pandemic on symptoms of anxiety and depression and health-related quality of life in older patients with chronic kidney disease
title_full	Impact of the COVID-19 pandemic on symptoms of anxiety and depression and health-related quality of life in older patients with chronic kidney disease
title_fullStr	Impact of the COVID-19 pandemic on symptoms of anxiety and depression and health-related quality of life in older patients with chronic kidney disease
title_full_unstemmed	Impact of the COVID-19 pandemic on symptoms of anxiety and depression and health-related quality of life in older patients with chronic kidney disease
title_sort	impact of the covid-19 pandemic on symptoms of anxiety and depression and health-related quality of life in older patients with chronic kidney disease
publisher	BMC
publishDate	2021
url	https://doaj.org/article/d15689734b4e43c9bf1461b8b8d0a7f4
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Impact of the COVID-19 pandemic on symptoms of anxiety and depression and health-related quality of life in older patients with chronic kidney disease

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