Impact of sex, fat distribution and initial body weight on oxytocin’s body weight regulation

Abstract Obesity is considered as a worldwide problem in both males and females. Although many studies have demonstrated the efficiency of oxytocin (Oxt) as an anti-obesity peptide, there is no comparative study of its effect in males and females. This study aims to determine factors (sex, initial b...

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Autores principales:	Yuko Maejima, Masato Aoyama, Kazuho Sakamoto, Teruo Jojima, Yoshimasa Aso, Katsuya Takasu, Seiichi Takenosihita, Kenju Shimomura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d1596357f40343548a920d5c7b1a50ea
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spelling	oai:doaj.org-article:d1596357f40343548a920d5c7b1a50ea2021-12-02T15:06:05ZImpact of sex, fat distribution and initial body weight on oxytocin’s body weight regulation10.1038/s41598-017-09318-72045-2322https://doaj.org/article/d1596357f40343548a920d5c7b1a50ea2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09318-7https://doaj.org/toc/2045-2322Abstract Obesity is considered as a worldwide problem in both males and females. Although many studies have demonstrated the efficiency of oxytocin (Oxt) as an anti-obesity peptide, there is no comparative study of its effect in males and females. This study aims to determine factors (sex, initial body weight, and fat distribution) that may affect the ability of Oxt to regulate body weight (BW). With regard to sex, Oxt reduced BW similarly in males and females under both high fat diet (HFD) and standard chow-fed condition. The BW reduction induced by Oxt correlated with initial BW in male and female mice under HFD conditions. Oxt showed an equal efficacy in fat degradation in both the visceral and subcutaneous fat mass in both males and females fed with HFD. The effect of Oxt on BW reduction was attenuated in standard chow-fed male and female mice. Therefore, our results suggest that administration of Oxt is more effective in reducing BW in subjects with a high initial BW with increased fat accumulation. The present data contains important information for the possible clinical application of Oxt for the treatment of obesity.Yuko MaejimaMasato AoyamaKazuho SakamotoTeruo JojimaYoshimasa AsoKatsuya TakasuSeiichi TakenosihitaKenju ShimomuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuko Maejima Masato Aoyama Kazuho Sakamoto Teruo Jojima Yoshimasa Aso Katsuya Takasu Seiichi Takenosihita Kenju Shimomura Impact of sex, fat distribution and initial body weight on oxytocin’s body weight regulation
description	Abstract Obesity is considered as a worldwide problem in both males and females. Although many studies have demonstrated the efficiency of oxytocin (Oxt) as an anti-obesity peptide, there is no comparative study of its effect in males and females. This study aims to determine factors (sex, initial body weight, and fat distribution) that may affect the ability of Oxt to regulate body weight (BW). With regard to sex, Oxt reduced BW similarly in males and females under both high fat diet (HFD) and standard chow-fed condition. The BW reduction induced by Oxt correlated with initial BW in male and female mice under HFD conditions. Oxt showed an equal efficacy in fat degradation in both the visceral and subcutaneous fat mass in both males and females fed with HFD. The effect of Oxt on BW reduction was attenuated in standard chow-fed male and female mice. Therefore, our results suggest that administration of Oxt is more effective in reducing BW in subjects with a high initial BW with increased fat accumulation. The present data contains important information for the possible clinical application of Oxt for the treatment of obesity.
format	article
author	Yuko Maejima Masato Aoyama Kazuho Sakamoto Teruo Jojima Yoshimasa Aso Katsuya Takasu Seiichi Takenosihita Kenju Shimomura
author_facet	Yuko Maejima Masato Aoyama Kazuho Sakamoto Teruo Jojima Yoshimasa Aso Katsuya Takasu Seiichi Takenosihita Kenju Shimomura
author_sort	Yuko Maejima
title	Impact of sex, fat distribution and initial body weight on oxytocin’s body weight regulation
title_short	Impact of sex, fat distribution and initial body weight on oxytocin’s body weight regulation
title_full	Impact of sex, fat distribution and initial body weight on oxytocin’s body weight regulation
title_fullStr	Impact of sex, fat distribution and initial body weight on oxytocin’s body weight regulation
title_full_unstemmed	Impact of sex, fat distribution and initial body weight on oxytocin’s body weight regulation
title_sort	impact of sex, fat distribution and initial body weight on oxytocin’s body weight regulation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d1596357f40343548a920d5c7b1a50ea
work_keys_str_mv	AT yukomaejima impactofsexfatdistributionandinitialbodyweightonoxytocinsbodyweightregulation AT masatoaoyama impactofsexfatdistributionandinitialbodyweightonoxytocinsbodyweightregulation AT kazuhosakamoto impactofsexfatdistributionandinitialbodyweightonoxytocinsbodyweightregulation AT teruojojima impactofsexfatdistributionandinitialbodyweightonoxytocinsbodyweightregulation AT yoshimasaaso impactofsexfatdistributionandinitialbodyweightonoxytocinsbodyweightregulation AT katsuyatakasu impactofsexfatdistributionandinitialbodyweightonoxytocinsbodyweightregulation AT seiichitakenosihita impactofsexfatdistributionandinitialbodyweightonoxytocinsbodyweightregulation AT kenjushimomura impactofsexfatdistributionandinitialbodyweightonoxytocinsbodyweightregulation
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Impact of sex, fat distribution and initial body weight on oxytocin’s body weight regulation

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