A Comparative Assessment of MR BI-RADS 4 Breast Lesions With Kaiser Score and Apparent Diffusion Coefficient Value

ObjectivesTo investigate the diagnostic performance of the Kaiser score and apparent diffusion coefficient (ADC) to differentiate Breast Imaging Reporting and Data System (BI-RADS) Category 4 lesions at dynamic contrast-enhanced (DCE) MRI.MethodsThis was a single-institution retrospective study of p...

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Autores principales:	Lingsong Meng, Xin Zhao, Lin Lu, Qingna Xing, Kaiyu Wang, Yafei Guo, Honglei Shang, Yan Chen, Mengyue Huang, Yongbing Sun, Xiaoan Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Kaiser score apparent diffusion coefficient breast cancer BI-RADS specificity Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/d162f03887a64d94b308b15d554791b1
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spelling	oai:doaj.org-article:d162f03887a64d94b308b15d554791b12021-12-02T10:54:07ZA Comparative Assessment of MR BI-RADS 4 Breast Lesions With Kaiser Score and Apparent Diffusion Coefficient Value2234-943X10.3389/fonc.2021.779642https://doaj.org/article/d162f03887a64d94b308b15d554791b12021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.779642/fullhttps://doaj.org/toc/2234-943XObjectivesTo investigate the diagnostic performance of the Kaiser score and apparent diffusion coefficient (ADC) to differentiate Breast Imaging Reporting and Data System (BI-RADS) Category 4 lesions at dynamic contrast-enhanced (DCE) MRI.MethodsThis was a single-institution retrospective study of patients who underwent breast MRI from March 2020 to June 2021. All image data were acquired with a 3-T MRI system. Kaiser score of each lesion was assigned by an experienced breast radiologist. Kaiser score+ was determined by combining ADC and Kaiser score. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic performance of Kaiser score+, Kaiser score, and ADC. The area under the curve (AUC) values were calculated and compared by using the Delong test. The differences in sensitivity and specificity between different indicators were determined by the McNemar test.ResultsThe study involved 243 women (mean age, 43.1 years; age range, 18–67 years) with 268 MR BI-RADS 4 lesions. Overall diagnostic performance for Kaiser score (AUC, 0.902) was significantly higher than for ADC (AUC, 0.81; p = 0.004). There were no significant differences in AUCs between Kaiser score and Kaiser score+ (p = 0.134). The Kaiser score was superior to ADC in avoiding unnecessary biopsies (p < 0.001). Compared with the Kaiser score alone, the specificity of Kaiser score+ increased by 7.82%, however, at the price of a lower sensitivity.ConclusionFor MR BI-RADS category 4 breast lesions, the Kaiser score was superior to ADC mapping regarding the potential to avoid unnecessary biopsies. However, the combination of both indicators did not significantly contribute to breast cancer diagnosis of this subgroup.Lingsong MengXin ZhaoLin LuQingna XingKaiyu WangYafei GuoHonglei ShangYan ChenMengyue HuangYongbing SunXiaoan ZhangFrontiers Media S.A.articleKaiser scoreapparent diffusion coefficientbreast cancerBI-RADSspecificityNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Kaiser score apparent diffusion coefficient breast cancer BI-RADS specificity Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Kaiser score apparent diffusion coefficient breast cancer BI-RADS specificity Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Lingsong Meng Xin Zhao Lin Lu Qingna Xing Kaiyu Wang Yafei Guo Honglei Shang Yan Chen Mengyue Huang Yongbing Sun Xiaoan Zhang A Comparative Assessment of MR BI-RADS 4 Breast Lesions With Kaiser Score and Apparent Diffusion Coefficient Value
description	ObjectivesTo investigate the diagnostic performance of the Kaiser score and apparent diffusion coefficient (ADC) to differentiate Breast Imaging Reporting and Data System (BI-RADS) Category 4 lesions at dynamic contrast-enhanced (DCE) MRI.MethodsThis was a single-institution retrospective study of patients who underwent breast MRI from March 2020 to June 2021. All image data were acquired with a 3-T MRI system. Kaiser score of each lesion was assigned by an experienced breast radiologist. Kaiser score+ was determined by combining ADC and Kaiser score. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic performance of Kaiser score+, Kaiser score, and ADC. The area under the curve (AUC) values were calculated and compared by using the Delong test. The differences in sensitivity and specificity between different indicators were determined by the McNemar test.ResultsThe study involved 243 women (mean age, 43.1 years; age range, 18–67 years) with 268 MR BI-RADS 4 lesions. Overall diagnostic performance for Kaiser score (AUC, 0.902) was significantly higher than for ADC (AUC, 0.81; p = 0.004). There were no significant differences in AUCs between Kaiser score and Kaiser score+ (p = 0.134). The Kaiser score was superior to ADC in avoiding unnecessary biopsies (p < 0.001). Compared with the Kaiser score alone, the specificity of Kaiser score+ increased by 7.82%, however, at the price of a lower sensitivity.ConclusionFor MR BI-RADS category 4 breast lesions, the Kaiser score was superior to ADC mapping regarding the potential to avoid unnecessary biopsies. However, the combination of both indicators did not significantly contribute to breast cancer diagnosis of this subgroup.
format	article
author	Lingsong Meng Xin Zhao Lin Lu Qingna Xing Kaiyu Wang Yafei Guo Honglei Shang Yan Chen Mengyue Huang Yongbing Sun Xiaoan Zhang
author_facet	Lingsong Meng Xin Zhao Lin Lu Qingna Xing Kaiyu Wang Yafei Guo Honglei Shang Yan Chen Mengyue Huang Yongbing Sun Xiaoan Zhang
author_sort	Lingsong Meng
title	A Comparative Assessment of MR BI-RADS 4 Breast Lesions With Kaiser Score and Apparent Diffusion Coefficient Value
title_short	A Comparative Assessment of MR BI-RADS 4 Breast Lesions With Kaiser Score and Apparent Diffusion Coefficient Value
title_full	A Comparative Assessment of MR BI-RADS 4 Breast Lesions With Kaiser Score and Apparent Diffusion Coefficient Value
title_fullStr	A Comparative Assessment of MR BI-RADS 4 Breast Lesions With Kaiser Score and Apparent Diffusion Coefficient Value
title_full_unstemmed	A Comparative Assessment of MR BI-RADS 4 Breast Lesions With Kaiser Score and Apparent Diffusion Coefficient Value
title_sort	comparative assessment of mr bi-rads 4 breast lesions with kaiser score and apparent diffusion coefficient value
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d162f03887a64d94b308b15d554791b1
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A Comparative Assessment of MR BI-RADS 4 Breast Lesions With Kaiser Score and Apparent Diffusion Coefficient Value

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