The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

It is known cutaneous squamous cell carcinoma (cSCC) involves a high tumour mutation burden. Here the authors identify common cSCC mutated genes, copy number changes, altered pathways and report the presence of a novel mutation signature associated with chronic exposure to the immunosuppressive drug...

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Autores principales:	Gareth J. Inman, Jun Wang, Ai Nagano, Ludmil B. Alexandrov, Karin J. Purdie, Richard G. Taylor, Victoria Sherwood, Jason Thomson, Sarah Hogan, Lindsay C. Spender, Andrew P. South, Michael Stratton, Claude Chelala, Catherine A. Harwood, Charlotte M. Proby, Irene M. Leigh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d162fea7f7de4883a5d53f89f08c61a7
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spelling	oai:doaj.org-article:d162fea7f7de4883a5d53f89f08c61a72021-12-02T17:32:45ZThe genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature10.1038/s41467-018-06027-12041-1723https://doaj.org/article/d162fea7f7de4883a5d53f89f08c61a72018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06027-1https://doaj.org/toc/2041-1723It is known cutaneous squamous cell carcinoma (cSCC) involves a high tumour mutation burden. Here the authors identify common cSCC mutated genes, copy number changes, altered pathways and report the presence of a novel mutation signature associated with chronic exposure to the immunosuppressive drug azathioprine.Gareth J. InmanJun WangAi NaganoLudmil B. AlexandrovKarin J. PurdieRichard G. TaylorVictoria SherwoodJason ThomsonSarah HoganLindsay C. SpenderAndrew P. SouthMichael StrattonClaude ChelalaCatherine A. HarwoodCharlotte M. ProbyIrene M. LeighNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gareth J. Inman Jun Wang Ai Nagano Ludmil B. Alexandrov Karin J. Purdie Richard G. Taylor Victoria Sherwood Jason Thomson Sarah Hogan Lindsay C. Spender Andrew P. South Michael Stratton Claude Chelala Catherine A. Harwood Charlotte M. Proby Irene M. Leigh The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature
description	It is known cutaneous squamous cell carcinoma (cSCC) involves a high tumour mutation burden. Here the authors identify common cSCC mutated genes, copy number changes, altered pathways and report the presence of a novel mutation signature associated with chronic exposure to the immunosuppressive drug azathioprine.
format	article
author	Gareth J. Inman Jun Wang Ai Nagano Ludmil B. Alexandrov Karin J. Purdie Richard G. Taylor Victoria Sherwood Jason Thomson Sarah Hogan Lindsay C. Spender Andrew P. South Michael Stratton Claude Chelala Catherine A. Harwood Charlotte M. Proby Irene M. Leigh
author_facet	Gareth J. Inman Jun Wang Ai Nagano Ludmil B. Alexandrov Karin J. Purdie Richard G. Taylor Victoria Sherwood Jason Thomson Sarah Hogan Lindsay C. Spender Andrew P. South Michael Stratton Claude Chelala Catherine A. Harwood Charlotte M. Proby Irene M. Leigh
author_sort	Gareth J. Inman
title	The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature
title_short	The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature
title_full	The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature
title_fullStr	The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature
title_full_unstemmed	The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature
title_sort	genomic landscape of cutaneous scc reveals drivers and a novel azathioprine associated mutational signature
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d162fea7f7de4883a5d53f89f08c61a7
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The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

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