The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

It is known cutaneous squamous cell carcinoma (cSCC) involves a high tumour mutation burden. Here the authors identify common cSCC mutated genes, copy number changes, altered pathways and report the presence of a novel mutation signature associated with chronic exposure to the immunosuppressive drug...

Full description

Saved in:
Bibliographic Details
Main Authors: Gareth J. Inman, Jun Wang, Ai Nagano, Ludmil B. Alexandrov, Karin J. Purdie, Richard G. Taylor, Victoria Sherwood, Jason Thomson, Sarah Hogan, Lindsay C. Spender, Andrew P. South, Michael Stratton, Claude Chelala, Catherine A. Harwood, Charlotte M. Proby, Irene M. Leigh
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Science
Q
Online Access:https://doaj.org/article/d162fea7f7de4883a5d53f89f08c61a7
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items