The effect of soybean-derived phosphatidylserine on cognitive performance in elderly with subjective memory complaints: a pilot study
Yael Richter, Yael Herzog, Yael Lifshitz, Rami Hayun, Sigalit ZchutEnzymotec Ltd, K’far Baruch, IsraelObjective: To evaluate the efficacy and safety of soybean-derived phosphatidylserine (SB-PS) (300 mg/day) in improving cognitive performance in elderly with memory complaints, following a...
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Dove Medical Press
2013
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oai:doaj.org-article:d167fe587d5949b6b1aa3de71241c6752021-12-02T00:37:30ZThe effect of soybean-derived phosphatidylserine on cognitive performance in elderly with subjective memory complaints: a pilot study1178-1998https://doaj.org/article/d167fe587d5949b6b1aa3de71241c6752013-05-01T00:00:00Zhttps://www.dovepress.com/the-effect-of-soybean-derived-phosphatidylserine-on-cognitive-performa-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Yael Richter, Yael Herzog, Yael Lifshitz, Rami Hayun, Sigalit ZchutEnzymotec Ltd, K’far Baruch, IsraelObjective: To evaluate the efficacy and safety of soybean-derived phosphatidylserine (SB-PS) (300 mg/day) in improving cognitive performance in elderly with memory complaints, following a short duration of 12 weeks’ SB-PS administration.Methods: SB-PS was administered daily for 12 weeks to 30 elderly volunteers with memory complaints (age range 50–90 years). Cognitive performance was determined by a computerized test battery and by the Rey Auditory Verbal Learning Test (Rey-AVLT). Physical examination and blood safety parameters were part of the extensive safety analysis of PS that was performed.Results: The computerized test results showed that SB-PS supplementation significantly increased the following cognitive parameters: memory recognition (P = 0.004), memory recall (P = 0.006), executive functions (P = 0.004), and mental flexibility (P = 0.01). The Rey-AVLT indicated that, following SB-PS administration, total learning and immediate recall improved significantly (P = 0.013 and P = 0.007, respectively). Unexpected results from the safety tests suggested that SB-PS significantly reduces both systolic (P = 0.043) and diastolic (P = 0.003) blood pressure. SB-PS consumption was well tolerated and no serious adverse events were reported during the study.Conclusion: This exploratory study demonstrates that SB-PS may have favorable effects on cognitive function in elderly with memory complaints. In addition, the study suggests that SB-PS is safe for human consumption and may serve as a safe alternative to phosphatidylserine extracted from bovine cortex. These results encourage further extended studies in order to establish the safety and efficacy of SB-PS treatment.Keywords: learning, AAMI, memory, cognitive, phosphatidylserineRichter YHerzog YLifshitz YHayun RZchut SDove Medical PressarticlelearningAAMImemorycognitivephosphatidylserineGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 8, Pp 557-563 (2013) |
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DOAJ |
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learning AAMI memory cognitive phosphatidylserine Geriatrics RC952-954.6 |
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learning AAMI memory cognitive phosphatidylserine Geriatrics RC952-954.6 Richter Y Herzog Y Lifshitz Y Hayun R Zchut S The effect of soybean-derived phosphatidylserine on cognitive performance in elderly with subjective memory complaints: a pilot study |
| description |
Yael Richter, Yael Herzog, Yael Lifshitz, Rami Hayun, Sigalit ZchutEnzymotec Ltd, K’far Baruch, IsraelObjective: To evaluate the efficacy and safety of soybean-derived phosphatidylserine (SB-PS) (300 mg/day) in improving cognitive performance in elderly with memory complaints, following a short duration of 12 weeks’ SB-PS administration.Methods: SB-PS was administered daily for 12 weeks to 30 elderly volunteers with memory complaints (age range 50–90 years). Cognitive performance was determined by a computerized test battery and by the Rey Auditory Verbal Learning Test (Rey-AVLT). Physical examination and blood safety parameters were part of the extensive safety analysis of PS that was performed.Results: The computerized test results showed that SB-PS supplementation significantly increased the following cognitive parameters: memory recognition (P = 0.004), memory recall (P = 0.006), executive functions (P = 0.004), and mental flexibility (P = 0.01). The Rey-AVLT indicated that, following SB-PS administration, total learning and immediate recall improved significantly (P = 0.013 and P = 0.007, respectively). Unexpected results from the safety tests suggested that SB-PS significantly reduces both systolic (P = 0.043) and diastolic (P = 0.003) blood pressure. SB-PS consumption was well tolerated and no serious adverse events were reported during the study.Conclusion: This exploratory study demonstrates that SB-PS may have favorable effects on cognitive function in elderly with memory complaints. In addition, the study suggests that SB-PS is safe for human consumption and may serve as a safe alternative to phosphatidylserine extracted from bovine cortex. These results encourage further extended studies in order to establish the safety and efficacy of SB-PS treatment.Keywords: learning, AAMI, memory, cognitive, phosphatidylserine |
| format |
article |
| author |
Richter Y Herzog Y Lifshitz Y Hayun R Zchut S |
| author_facet |
Richter Y Herzog Y Lifshitz Y Hayun R Zchut S |
| author_sort |
Richter Y |
| title |
The effect of soybean-derived phosphatidylserine on cognitive performance in elderly with subjective memory complaints: a pilot study |
| title_short |
The effect of soybean-derived phosphatidylserine on cognitive performance in elderly with subjective memory complaints: a pilot study |
| title_full |
The effect of soybean-derived phosphatidylserine on cognitive performance in elderly with subjective memory complaints: a pilot study |
| title_fullStr |
The effect of soybean-derived phosphatidylserine on cognitive performance in elderly with subjective memory complaints: a pilot study |
| title_full_unstemmed |
The effect of soybean-derived phosphatidylserine on cognitive performance in elderly with subjective memory complaints: a pilot study |
| title_sort |
effect of soybean-derived phosphatidylserine on cognitive performance in elderly with subjective memory complaints: a pilot study |
| publisher |
Dove Medical Press |
| publishDate |
2013 |
| url |
https://doaj.org/article/d167fe587d5949b6b1aa3de71241c675 |
| work_keys_str_mv |
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