The Association of Circulating Selenium Concentrations with Diabetes Mellitus

Xiao-Long Liao, Zhong-Hua Wang, Xiu-Na Liang, Jun Liang, Xue-Biao Wei, Shou-Hong Wang, Wei-Xin Guo Department of Critical Care Medicine, Guangdong Provincial Geriatrics Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, People&rs...

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Autores principales:	Liao XL, Wang ZH, Liang XN, Liang J, Wei XB, Wang SH, Guo WX
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	diabetes mellitus selenium relationship Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/d16977d63d404a51a56246d46e7a01c3
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spelling	oai:doaj.org-article:d16977d63d404a51a56246d46e7a01c32021-12-02T12:27:46ZThe Association of Circulating Selenium Concentrations with Diabetes Mellitus1178-7007https://doaj.org/article/d16977d63d404a51a56246d46e7a01c32020-12-01T00:00:00Zhttps://www.dovepress.com/the-association-of-circulating-selenium-concentrations-with-diabetes-m-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Xiao-Long Liao, Zhong-Hua Wang, Xiu-Na Liang, Jun Liang, Xue-Biao Wei, Shou-Hong Wang, Wei-Xin Guo Department of Critical Care Medicine, Guangdong Provincial Geriatrics Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, People’s Republic of ChinaCorrespondence: Shou-Hong Wang; Wei-Xin GuoDepartment of Critical Care Medicine, Guangdong Provincial Geriatrics Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan Road 2, Guangzhou 510080, People’s Republic of ChinaTel/Fax +86-20-83827812Email gdwangshouhong@163.com; gguosumly@163.comPurpose: The relationship between circulating selenium and diabetes mellitus (DM) remains inconsistent. Therefore, the relationship between circulating selenium and DM was investigated in the present study.Patients and Methods: All participants (aged ≥ 18 years) were included from the National Health and Nutrition Examination Survey (NHANES) 1999– 2006. Selenium concentrations from the fasting serum samples were determined using inductively coupled mass spectrometry, then grouped into quartiles. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by using multivariate logistic regression analysis and the results were stratified by age and sex.Results: A total of 2,903 (61.9± 13.7 years old) participants (49.3% males) were enrolled, and 580 (19.97%) of them had DM. The mean levels of selenium were 136.4± 19.6 μg/L. Patients with DM (138.76± 20.02 vs 135.88± 19.44, P=0.002) had higher selenium levels compared to those without DM. The OR for DM was 1.12 (95% CI=1.01– 1.24; P=0.0270) for each 10 μg/L increment in selenium, and subjects in the highest quartile of selenium levels (> 147.00 uμg/L) had 2.82 (95% CI=1.55– 5.11; P=0.0007) times higher risk of DM compared to the lowest quartile of selenium levels. Subgroup analysis showed that selenium was independently associated with DM only in female aged < 65 years.Conclusion: Circulating selenium levels were positively associated with the odds of DM, but difference in sex and age.Keywords: diabetes mellitus, selenium, relationshipLiao XLWang ZHLiang XNLiang JWei XBWang SHGuo WXDove Medical Pressarticlediabetes mellitusseleniumrelationshipSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 4755-4761 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus selenium relationship Specialties of internal medicine RC581-951
spellingShingle	diabetes mellitus selenium relationship Specialties of internal medicine RC581-951 Liao XL Wang ZH Liang XN Liang J Wei XB Wang SH Guo WX The Association of Circulating Selenium Concentrations with Diabetes Mellitus
description	Xiao-Long Liao, Zhong-Hua Wang, Xiu-Na Liang, Jun Liang, Xue-Biao Wei, Shou-Hong Wang, Wei-Xin Guo Department of Critical Care Medicine, Guangdong Provincial Geriatrics Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, People’s Republic of ChinaCorrespondence: Shou-Hong Wang; Wei-Xin GuoDepartment of Critical Care Medicine, Guangdong Provincial Geriatrics Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan Road 2, Guangzhou 510080, People’s Republic of ChinaTel/Fax +86-20-83827812Email gdwangshouhong@163.com; gguosumly@163.comPurpose: The relationship between circulating selenium and diabetes mellitus (DM) remains inconsistent. Therefore, the relationship between circulating selenium and DM was investigated in the present study.Patients and Methods: All participants (aged ≥ 18 years) were included from the National Health and Nutrition Examination Survey (NHANES) 1999– 2006. Selenium concentrations from the fasting serum samples were determined using inductively coupled mass spectrometry, then grouped into quartiles. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by using multivariate logistic regression analysis and the results were stratified by age and sex.Results: A total of 2,903 (61.9± 13.7 years old) participants (49.3% males) were enrolled, and 580 (19.97%) of them had DM. The mean levels of selenium were 136.4± 19.6 μg/L. Patients with DM (138.76± 20.02 vs 135.88± 19.44, P=0.002) had higher selenium levels compared to those without DM. The OR for DM was 1.12 (95% CI=1.01– 1.24; P=0.0270) for each 10 μg/L increment in selenium, and subjects in the highest quartile of selenium levels (> 147.00 uμg/L) had 2.82 (95% CI=1.55– 5.11; P=0.0007) times higher risk of DM compared to the lowest quartile of selenium levels. Subgroup analysis showed that selenium was independently associated with DM only in female aged < 65 years.Conclusion: Circulating selenium levels were positively associated with the odds of DM, but difference in sex and age.Keywords: diabetes mellitus, selenium, relationship
format	article
author	Liao XL Wang ZH Liang XN Liang J Wei XB Wang SH Guo WX
author_facet	Liao XL Wang ZH Liang XN Liang J Wei XB Wang SH Guo WX
author_sort	Liao XL
title	The Association of Circulating Selenium Concentrations with Diabetes Mellitus
title_short	The Association of Circulating Selenium Concentrations with Diabetes Mellitus
title_full	The Association of Circulating Selenium Concentrations with Diabetes Mellitus
title_fullStr	The Association of Circulating Selenium Concentrations with Diabetes Mellitus
title_full_unstemmed	The Association of Circulating Selenium Concentrations with Diabetes Mellitus
title_sort	association of circulating selenium concentrations with diabetes mellitus
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/d16977d63d404a51a56246d46e7a01c3
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The Association of Circulating Selenium Concentrations with Diabetes Mellitus

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