Dendritic spine density is increased on nucleus accumbens D2 neurons after chronic social defeat

Abstract Stress alters the structure and function of brain reward circuitry and is an important risk factor for developing depression. In the nucleus accumbens (NAc), structural and physiological plasticity of medium spiny neurons (MSNs) have been linked to increased stress-related and depression-li...

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Autores principales:	Megan E. Fox, Antonio Figueiredo, Miriam S. Menken, Mary Kay Lobo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d16bc7fad6024b85a3b46d766c46053b
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id	oai:doaj.org-article:d16bc7fad6024b85a3b46d766c46053b
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spelling	oai:doaj.org-article:d16bc7fad6024b85a3b46d766c46053b2021-12-02T16:26:22ZDendritic spine density is increased on nucleus accumbens D2 neurons after chronic social defeat10.1038/s41598-020-69339-72045-2322https://doaj.org/article/d16bc7fad6024b85a3b46d766c46053b2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-69339-7https://doaj.org/toc/2045-2322Abstract Stress alters the structure and function of brain reward circuitry and is an important risk factor for developing depression. In the nucleus accumbens (NAc), structural and physiological plasticity of medium spiny neurons (MSNs) have been linked to increased stress-related and depression-like behaviors. NAc MSNs have opposing roles in driving stress-related behaviors that is dependent on their dopamine receptor expression. After chronic social defeat stress, NAc MSNs exhibit increased dendritic spine density. However, it remains unclear if the dendritic spine plasticity is MSN subtype specific. Here we use viral labeling to characterize dendritic spine morphology specifically in dopamine D2 receptor expressing MSNs (D2-MSNs). After chronic social defeat, D2-MSNs exhibit increased spine density that is correlated with enhanced social avoidance behavior. Together, our data indicate dendritic spine plasticity is MSN subtype specific, improving our understanding of structural plasticity after chronic stress.Megan E. FoxAntonio FigueiredoMiriam S. MenkenMary Kay LoboNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Megan E. Fox Antonio Figueiredo Miriam S. Menken Mary Kay Lobo Dendritic spine density is increased on nucleus accumbens D2 neurons after chronic social defeat
description	Abstract Stress alters the structure and function of brain reward circuitry and is an important risk factor for developing depression. In the nucleus accumbens (NAc), structural and physiological plasticity of medium spiny neurons (MSNs) have been linked to increased stress-related and depression-like behaviors. NAc MSNs have opposing roles in driving stress-related behaviors that is dependent on their dopamine receptor expression. After chronic social defeat stress, NAc MSNs exhibit increased dendritic spine density. However, it remains unclear if the dendritic spine plasticity is MSN subtype specific. Here we use viral labeling to characterize dendritic spine morphology specifically in dopamine D2 receptor expressing MSNs (D2-MSNs). After chronic social defeat, D2-MSNs exhibit increased spine density that is correlated with enhanced social avoidance behavior. Together, our data indicate dendritic spine plasticity is MSN subtype specific, improving our understanding of structural plasticity after chronic stress.
format	article
author	Megan E. Fox Antonio Figueiredo Miriam S. Menken Mary Kay Lobo
author_facet	Megan E. Fox Antonio Figueiredo Miriam S. Menken Mary Kay Lobo
author_sort	Megan E. Fox
title	Dendritic spine density is increased on nucleus accumbens D2 neurons after chronic social defeat
title_short	Dendritic spine density is increased on nucleus accumbens D2 neurons after chronic social defeat
title_full	Dendritic spine density is increased on nucleus accumbens D2 neurons after chronic social defeat
title_fullStr	Dendritic spine density is increased on nucleus accumbens D2 neurons after chronic social defeat
title_full_unstemmed	Dendritic spine density is increased on nucleus accumbens D2 neurons after chronic social defeat
title_sort	dendritic spine density is increased on nucleus accumbens d2 neurons after chronic social defeat
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d16bc7fad6024b85a3b46d766c46053b
work_keys_str_mv	AT meganefox dendriticspinedensityisincreasedonnucleusaccumbensd2neuronsafterchronicsocialdefeat AT antoniofigueiredo dendriticspinedensityisincreasedonnucleusaccumbensd2neuronsafterchronicsocialdefeat AT miriamsmenken dendriticspinedensityisincreasedonnucleusaccumbensd2neuronsafterchronicsocialdefeat AT marykaylobo dendriticspinedensityisincreasedonnucleusaccumbensd2neuronsafterchronicsocialdefeat
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Dendritic spine density is increased on nucleus accumbens D2 neurons after chronic social defeat

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