Optically-controlled bacterial metabolite for cancer therapy

Targeting tumors with bacteria as vehicles for metabolite therapy suffers from low efficiency and robustness. Here, the authors combine carbon nitride with nitric oxide generation enzyme-positive E. coli for photo-controlled metabolite therapy (PMT) and observe increased effects both in vitro and in...

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Autores principales: Di-Wei Zheng, Ying Chen, Zi-Hao Li, Lu Xu, Chu-Xin Li, Bin Li, Jin-Xuan Fan, Si-Xue Cheng, Xian-Zheng Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/d16bc80f86904250a7bda65fe7249261
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Sumario:Targeting tumors with bacteria as vehicles for metabolite therapy suffers from low efficiency and robustness. Here, the authors combine carbon nitride with nitric oxide generation enzyme-positive E. coli for photo-controlled metabolite therapy (PMT) and observe increased effects both in vitro and in tumor-bearing mice.