Optically-controlled bacterial metabolite for cancer therapy

Targeting tumors with bacteria as vehicles for metabolite therapy suffers from low efficiency and robustness. Here, the authors combine carbon nitride with nitric oxide generation enzyme-positive E. coli for photo-controlled metabolite therapy (PMT) and observe increased effects both in vitro and in...

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Autores principales: Di-Wei Zheng, Ying Chen, Zi-Hao Li, Lu Xu, Chu-Xin Li, Bin Li, Jin-Xuan Fan, Si-Xue Cheng, Xian-Zheng Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/d16bc80f86904250a7bda65fe7249261
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spelling oai:doaj.org-article:d16bc80f86904250a7bda65fe72492612021-12-02T17:31:57ZOptically-controlled bacterial metabolite for cancer therapy10.1038/s41467-018-03233-92041-1723https://doaj.org/article/d16bc80f86904250a7bda65fe72492612018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03233-9https://doaj.org/toc/2041-1723Targeting tumors with bacteria as vehicles for metabolite therapy suffers from low efficiency and robustness. Here, the authors combine carbon nitride with nitric oxide generation enzyme-positive E. coli for photo-controlled metabolite therapy (PMT) and observe increased effects both in vitro and in tumor-bearing mice.Di-Wei ZhengYing ChenZi-Hao LiLu XuChu-Xin LiBin LiJin-Xuan FanSi-Xue ChengXian-Zheng ZhangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Di-Wei Zheng
Ying Chen
Zi-Hao Li
Lu Xu
Chu-Xin Li
Bin Li
Jin-Xuan Fan
Si-Xue Cheng
Xian-Zheng Zhang
Optically-controlled bacterial metabolite for cancer therapy
description Targeting tumors with bacteria as vehicles for metabolite therapy suffers from low efficiency and robustness. Here, the authors combine carbon nitride with nitric oxide generation enzyme-positive E. coli for photo-controlled metabolite therapy (PMT) and observe increased effects both in vitro and in tumor-bearing mice.
format article
author Di-Wei Zheng
Ying Chen
Zi-Hao Li
Lu Xu
Chu-Xin Li
Bin Li
Jin-Xuan Fan
Si-Xue Cheng
Xian-Zheng Zhang
author_facet Di-Wei Zheng
Ying Chen
Zi-Hao Li
Lu Xu
Chu-Xin Li
Bin Li
Jin-Xuan Fan
Si-Xue Cheng
Xian-Zheng Zhang
author_sort Di-Wei Zheng
title Optically-controlled bacterial metabolite for cancer therapy
title_short Optically-controlled bacterial metabolite for cancer therapy
title_full Optically-controlled bacterial metabolite for cancer therapy
title_fullStr Optically-controlled bacterial metabolite for cancer therapy
title_full_unstemmed Optically-controlled bacterial metabolite for cancer therapy
title_sort optically-controlled bacterial metabolite for cancer therapy
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/d16bc80f86904250a7bda65fe7249261
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AT chuxinli opticallycontrolledbacterialmetaboliteforcancertherapy
AT binli opticallycontrolledbacterialmetaboliteforcancertherapy
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