Bone Marrow Adipocytes: A Critical Player in the Bone Marrow Microenvironment

Recognized for nearly 100 years, bone marrow adipocytes (BMAs) form bone marrow niches that contain hematopoietic and bone cells, the roles of which have long been underestimated. Distinct from canonical white, brown, and beige adipocytes, BMAs derived from bone marrow mesenchymal stromal cells poss...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lipeng Wang, Hao Zhang, Sicheng Wang, Xiao Chen, Jiacan Su
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	bone marrow adipocytes bone marrow mesenchymal stromal cells hematopoiesis osteogenesis osteoclastogenesis immune regulation Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d16f784e834f4712a108f414e566838f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d16f784e834f4712a108f414e566838f
record_format	dspace
spelling	oai:doaj.org-article:d16f784e834f4712a108f414e566838f2021-12-01T13:29:59ZBone Marrow Adipocytes: A Critical Player in the Bone Marrow Microenvironment2296-634X10.3389/fcell.2021.770705https://doaj.org/article/d16f784e834f4712a108f414e566838f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.770705/fullhttps://doaj.org/toc/2296-634XRecognized for nearly 100 years, bone marrow adipocytes (BMAs) form bone marrow niches that contain hematopoietic and bone cells, the roles of which have long been underestimated. Distinct from canonical white, brown, and beige adipocytes, BMAs derived from bone marrow mesenchymal stromal cells possess unique characteristics and functions. Recent single-cell sequencing studies have revealed the differentiation pathway, and seminal works support the tenet that BMAs are critical regulators in hematopoiesis, osteogenesis, and osteoclastogenesis. In this review, we discuss the origin and differentiation of BMAs, as well as the roles of BMAs in hematopoiesis, osteogenesis, osteoclastogenesis, and immune regulation. Overall, BMAs represent a novel target for bone marrow-related diseases, including osteoporosis and leukemia.Lipeng WangHao ZhangSicheng WangXiao ChenJiacan SuJiacan SuFrontiers Media S.A.articlebone marrow adipocytesbone marrow mesenchymal stromal cellshematopoiesisosteogenesisosteoclastogenesisimmune regulationBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bone marrow adipocytes bone marrow mesenchymal stromal cells hematopoiesis osteogenesis osteoclastogenesis immune regulation Biology (General) QH301-705.5
spellingShingle	bone marrow adipocytes bone marrow mesenchymal stromal cells hematopoiesis osteogenesis osteoclastogenesis immune regulation Biology (General) QH301-705.5 Lipeng Wang Hao Zhang Sicheng Wang Xiao Chen Jiacan Su Jiacan Su Bone Marrow Adipocytes: A Critical Player in the Bone Marrow Microenvironment
description	Recognized for nearly 100 years, bone marrow adipocytes (BMAs) form bone marrow niches that contain hematopoietic and bone cells, the roles of which have long been underestimated. Distinct from canonical white, brown, and beige adipocytes, BMAs derived from bone marrow mesenchymal stromal cells possess unique characteristics and functions. Recent single-cell sequencing studies have revealed the differentiation pathway, and seminal works support the tenet that BMAs are critical regulators in hematopoiesis, osteogenesis, and osteoclastogenesis. In this review, we discuss the origin and differentiation of BMAs, as well as the roles of BMAs in hematopoiesis, osteogenesis, osteoclastogenesis, and immune regulation. Overall, BMAs represent a novel target for bone marrow-related diseases, including osteoporosis and leukemia.
format	article
author	Lipeng Wang Hao Zhang Sicheng Wang Xiao Chen Jiacan Su Jiacan Su
author_facet	Lipeng Wang Hao Zhang Sicheng Wang Xiao Chen Jiacan Su Jiacan Su
author_sort	Lipeng Wang
title	Bone Marrow Adipocytes: A Critical Player in the Bone Marrow Microenvironment
title_short	Bone Marrow Adipocytes: A Critical Player in the Bone Marrow Microenvironment
title_full	Bone Marrow Adipocytes: A Critical Player in the Bone Marrow Microenvironment
title_fullStr	Bone Marrow Adipocytes: A Critical Player in the Bone Marrow Microenvironment
title_full_unstemmed	Bone Marrow Adipocytes: A Critical Player in the Bone Marrow Microenvironment
title_sort	bone marrow adipocytes: a critical player in the bone marrow microenvironment
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d16f784e834f4712a108f414e566838f
work_keys_str_mv	AT lipengwang bonemarrowadipocytesacriticalplayerinthebonemarrowmicroenvironment AT haozhang bonemarrowadipocytesacriticalplayerinthebonemarrowmicroenvironment AT sichengwang bonemarrowadipocytesacriticalplayerinthebonemarrowmicroenvironment AT xiaochen bonemarrowadipocytesacriticalplayerinthebonemarrowmicroenvironment AT jiacansu bonemarrowadipocytesacriticalplayerinthebonemarrowmicroenvironment AT jiacansu bonemarrowadipocytesacriticalplayerinthebonemarrowmicroenvironment
_version_	1718405141584936960

Bone Marrow Adipocytes: A Critical Player in the Bone Marrow Microenvironment

Ejemplares similares