Complex small-world regulatory networks emerge from the 3D organisation of the human genome

Gene-regulatory networks are thought to be complex, and yet perturbation of just a few transcription factors (TFs) can have major consequences. Here the authors apply DNA polymer modelling and simulations to predict how 3D genome structure and TF-DNA interactions can give rise to transcriptional reg...

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Autores principales:	C. A. Brackley, N. Gilbert, D. Michieletto, A. Papantonis, M. C. F. Pereira, P. R. Cook, D. Marenduzzo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d1745e903b2a43babee8990c92ff7cec
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spelling	oai:doaj.org-article:d1745e903b2a43babee8990c92ff7cec2021-12-02T18:51:37ZComplex small-world regulatory networks emerge from the 3D organisation of the human genome10.1038/s41467-021-25875-y2041-1723https://doaj.org/article/d1745e903b2a43babee8990c92ff7cec2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25875-yhttps://doaj.org/toc/2041-1723Gene-regulatory networks are thought to be complex, and yet perturbation of just a few transcription factors (TFs) can have major consequences. Here the authors apply DNA polymer modelling and simulations to predict how 3D genome structure and TF-DNA interactions can give rise to transcriptional regulation operating over broad genomic regions, where small perturbations can have long-reaching effects.C. A. BrackleyN. GilbertD. MichielettoA. PapantonisM. C. F. PereiraP. R. CookD. MarenduzzoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q C. A. Brackley N. Gilbert D. Michieletto A. Papantonis M. C. F. Pereira P. R. Cook D. Marenduzzo Complex small-world regulatory networks emerge from the 3D organisation of the human genome
description	Gene-regulatory networks are thought to be complex, and yet perturbation of just a few transcription factors (TFs) can have major consequences. Here the authors apply DNA polymer modelling and simulations to predict how 3D genome structure and TF-DNA interactions can give rise to transcriptional regulation operating over broad genomic regions, where small perturbations can have long-reaching effects.
format	article
author	C. A. Brackley N. Gilbert D. Michieletto A. Papantonis M. C. F. Pereira P. R. Cook D. Marenduzzo
author_facet	C. A. Brackley N. Gilbert D. Michieletto A. Papantonis M. C. F. Pereira P. R. Cook D. Marenduzzo
author_sort	C. A. Brackley
title	Complex small-world regulatory networks emerge from the 3D organisation of the human genome
title_short	Complex small-world regulatory networks emerge from the 3D organisation of the human genome
title_full	Complex small-world regulatory networks emerge from the 3D organisation of the human genome
title_fullStr	Complex small-world regulatory networks emerge from the 3D organisation of the human genome
title_full_unstemmed	Complex small-world regulatory networks emerge from the 3D organisation of the human genome
title_sort	complex small-world regulatory networks emerge from the 3d organisation of the human genome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d1745e903b2a43babee8990c92ff7cec
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Complex small-world regulatory networks emerge from the 3D organisation of the human genome

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