Molecular Mechanism of Astragaloside IV in Improving Endothelial Dysfunction of Cardiovascular Diseases Mediated by Oxidative Stress

Endothelial dysfunction, induced by oxidative stress, is an essential factor affecting cardiovascular disease. Uncoupling of endothelial nitric oxide synthase (eNOS) leads to a decrease in nitric oxide (NO) production, an increase in reactive oxygen species (ROS) production, NO consumption, and NO s...

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Autores principales: Peipei Meng, Rui Yang, Fenjun Jiang, Jianbo Guo, Xinyu Lu, Tao Yang, Qingyong He
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Publicado: Hindawi Limited 2021
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spelling oai:doaj.org-article:d17ae168b17d41389f66aa75dad7adec2021-11-29T00:56:47ZMolecular Mechanism of Astragaloside IV in Improving Endothelial Dysfunction of Cardiovascular Diseases Mediated by Oxidative Stress1942-099410.1155/2021/1481236https://doaj.org/article/d17ae168b17d41389f66aa75dad7adec2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/1481236https://doaj.org/toc/1942-0994Endothelial dysfunction, induced by oxidative stress, is an essential factor affecting cardiovascular disease. Uncoupling of endothelial nitric oxide synthase (eNOS) leads to a decrease in nitric oxide (NO) production, an increase in reactive oxygen species (ROS) production, NO consumption, and NO synthesis. As a main active ingredient of astragalus, astragaloside IV can reduce the apoptosis of endothelial cells during oxidative stress. This review is aimed at exploring the mechanism of astragaloside IV in improving oxidative stress-mediated endothelial dysfunction relevant to cardiovascular diseases. The findings showed that the astragaloside IV can prevent or reverse the uncoupling of eNOS, increase eNOS and NO, and enhance several activating enzymes to activate the antioxidant system. In-depth validation and quantitative experiments still need to be implemented.Peipei MengRui YangFenjun JiangJianbo GuoXinyu LuTao YangQingyong HeHindawi LimitedarticleCytologyQH573-671ENOxidative Medicine and Cellular Longevity, Vol 2021 (2021)
institution DOAJ
collection DOAJ
language EN
topic Cytology
QH573-671
spellingShingle Cytology
QH573-671
Peipei Meng
Rui Yang
Fenjun Jiang
Jianbo Guo
Xinyu Lu
Tao Yang
Qingyong He
Molecular Mechanism of Astragaloside IV in Improving Endothelial Dysfunction of Cardiovascular Diseases Mediated by Oxidative Stress
description Endothelial dysfunction, induced by oxidative stress, is an essential factor affecting cardiovascular disease. Uncoupling of endothelial nitric oxide synthase (eNOS) leads to a decrease in nitric oxide (NO) production, an increase in reactive oxygen species (ROS) production, NO consumption, and NO synthesis. As a main active ingredient of astragalus, astragaloside IV can reduce the apoptosis of endothelial cells during oxidative stress. This review is aimed at exploring the mechanism of astragaloside IV in improving oxidative stress-mediated endothelial dysfunction relevant to cardiovascular diseases. The findings showed that the astragaloside IV can prevent or reverse the uncoupling of eNOS, increase eNOS and NO, and enhance several activating enzymes to activate the antioxidant system. In-depth validation and quantitative experiments still need to be implemented.
format article
author Peipei Meng
Rui Yang
Fenjun Jiang
Jianbo Guo
Xinyu Lu
Tao Yang
Qingyong He
author_facet Peipei Meng
Rui Yang
Fenjun Jiang
Jianbo Guo
Xinyu Lu
Tao Yang
Qingyong He
author_sort Peipei Meng
title Molecular Mechanism of Astragaloside IV in Improving Endothelial Dysfunction of Cardiovascular Diseases Mediated by Oxidative Stress
title_short Molecular Mechanism of Astragaloside IV in Improving Endothelial Dysfunction of Cardiovascular Diseases Mediated by Oxidative Stress
title_full Molecular Mechanism of Astragaloside IV in Improving Endothelial Dysfunction of Cardiovascular Diseases Mediated by Oxidative Stress
title_fullStr Molecular Mechanism of Astragaloside IV in Improving Endothelial Dysfunction of Cardiovascular Diseases Mediated by Oxidative Stress
title_full_unstemmed Molecular Mechanism of Astragaloside IV in Improving Endothelial Dysfunction of Cardiovascular Diseases Mediated by Oxidative Stress
title_sort molecular mechanism of astragaloside iv in improving endothelial dysfunction of cardiovascular diseases mediated by oxidative stress
publisher Hindawi Limited
publishDate 2021
url https://doaj.org/article/d17ae168b17d41389f66aa75dad7adec
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