Positive Selection Inhibits Plasmid Coexistence in Bacterial Genomes

Bacterial genomes often contain multiple coexisting plasmids that provide important functions like antibiotic resistance. Using lab experiments, we show that such plasmid coexistence within a genome is stable only in environments where the function they encode is useless but is unstable if the func...

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Autores principales:	Laura Carrilero, Anastasia Kottara, David Guymer, Ellie Harrison, James P. J. Hall, Michael A. Brockhurst
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/d17b325909d34cb795fd1f22be20be38
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spelling	oai:doaj.org-article:d17b325909d34cb795fd1f22be20be382021-11-03T21:15:03ZPositive Selection Inhibits Plasmid Coexistence in Bacterial Genomes2150-751110.1128/mBio.00558-21https://doaj.org/article/d17b325909d34cb795fd1f22be20be382021-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00558-21https://doaj.org/toc/2150-7511 Bacterial genomes often contain multiple coexisting plasmids that provide important functions like antibiotic resistance. Using lab experiments, we show that such plasmid coexistence within a genome is stable only in environments where the function they encode is useless but is unstable if the function is useful and beneficial for bacterial fitness.Laura CarrileroAnastasia KottaraDavid GuymerEllie HarrisonJames P. J. HallMichael A. BrockhurstAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Laura Carrilero Anastasia Kottara David Guymer Ellie Harrison James P. J. Hall Michael A. Brockhurst Positive Selection Inhibits Plasmid Coexistence in Bacterial Genomes
description	Bacterial genomes often contain multiple coexisting plasmids that provide important functions like antibiotic resistance. Using lab experiments, we show that such plasmid coexistence within a genome is stable only in environments where the function they encode is useless but is unstable if the function is useful and beneficial for bacterial fitness.
format	article
author	Laura Carrilero Anastasia Kottara David Guymer Ellie Harrison James P. J. Hall Michael A. Brockhurst
author_facet	Laura Carrilero Anastasia Kottara David Guymer Ellie Harrison James P. J. Hall Michael A. Brockhurst
author_sort	Laura Carrilero
title	Positive Selection Inhibits Plasmid Coexistence in Bacterial Genomes
title_short	Positive Selection Inhibits Plasmid Coexistence in Bacterial Genomes
title_full	Positive Selection Inhibits Plasmid Coexistence in Bacterial Genomes
title_fullStr	Positive Selection Inhibits Plasmid Coexistence in Bacterial Genomes
title_full_unstemmed	Positive Selection Inhibits Plasmid Coexistence in Bacterial Genomes
title_sort	positive selection inhibits plasmid coexistence in bacterial genomes
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/d17b325909d34cb795fd1f22be20be38
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Positive Selection Inhibits Plasmid Coexistence in Bacterial Genomes

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