Towards a comprehensive understanding of the structural dynamics of a bacterial diterpene synthase during catalysis

The bacterial diterpene synthase CotB2 catalyses the cyclisation of geranylgeranyl diphosphate to cyclooctat-9-en7-ol. Here the authors present various CotB2 structures including a trapped abrupt reaction product that were used for molecular dynamic simulations and allowed them to model all intermed...

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Autores principales:	Ronja Driller, Sophie Janke, Monika Fuchs, Evelyn Warner, Anil R. Mhashal, Dan Thomas Major, Mathias Christmann, Thomas Brück, Bernhard Loll
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d17e467129ff4b9c86987611db040f82
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spelling	oai:doaj.org-article:d17e467129ff4b9c86987611db040f822021-12-02T15:33:34ZTowards a comprehensive understanding of the structural dynamics of a bacterial diterpene synthase during catalysis10.1038/s41467-018-06325-82041-1723https://doaj.org/article/d17e467129ff4b9c86987611db040f822018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06325-8https://doaj.org/toc/2041-1723The bacterial diterpene synthase CotB2 catalyses the cyclisation of geranylgeranyl diphosphate to cyclooctat-9-en7-ol. Here the authors present various CotB2 structures including a trapped abrupt reaction product that were used for molecular dynamic simulations and allowed them to model all intermediates along the reaction cascade.Ronja DrillerSophie JankeMonika FuchsEvelyn WarnerAnil R. MhashalDan Thomas MajorMathias ChristmannThomas BrückBernhard LollNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ronja Driller Sophie Janke Monika Fuchs Evelyn Warner Anil R. Mhashal Dan Thomas Major Mathias Christmann Thomas Brück Bernhard Loll Towards a comprehensive understanding of the structural dynamics of a bacterial diterpene synthase during catalysis
description	The bacterial diterpene synthase CotB2 catalyses the cyclisation of geranylgeranyl diphosphate to cyclooctat-9-en7-ol. Here the authors present various CotB2 structures including a trapped abrupt reaction product that were used for molecular dynamic simulations and allowed them to model all intermediates along the reaction cascade.
format	article
author	Ronja Driller Sophie Janke Monika Fuchs Evelyn Warner Anil R. Mhashal Dan Thomas Major Mathias Christmann Thomas Brück Bernhard Loll
author_facet	Ronja Driller Sophie Janke Monika Fuchs Evelyn Warner Anil R. Mhashal Dan Thomas Major Mathias Christmann Thomas Brück Bernhard Loll
author_sort	Ronja Driller
title	Towards a comprehensive understanding of the structural dynamics of a bacterial diterpene synthase during catalysis
title_short	Towards a comprehensive understanding of the structural dynamics of a bacterial diterpene synthase during catalysis
title_full	Towards a comprehensive understanding of the structural dynamics of a bacterial diterpene synthase during catalysis
title_fullStr	Towards a comprehensive understanding of the structural dynamics of a bacterial diterpene synthase during catalysis
title_full_unstemmed	Towards a comprehensive understanding of the structural dynamics of a bacterial diterpene synthase during catalysis
title_sort	towards a comprehensive understanding of the structural dynamics of a bacterial diterpene synthase during catalysis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d17e467129ff4b9c86987611db040f82
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Towards a comprehensive understanding of the structural dynamics of a bacterial diterpene synthase during catalysis

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