Towards a comprehensive understanding of the structural dynamics of a bacterial diterpene synthase during catalysis

The bacterial diterpene synthase CotB2 catalyses the cyclisation of geranylgeranyl diphosphate to cyclooctat-9-en7-ol. Here the authors present various CotB2 structures including a trapped abrupt reaction product that were used for molecular dynamic simulations and allowed them to model all intermed...

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Autores principales: Ronja Driller, Sophie Janke, Monika Fuchs, Evelyn Warner, Anil R. Mhashal, Dan Thomas Major, Mathias Christmann, Thomas Brück, Bernhard Loll
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/d17e467129ff4b9c86987611db040f82
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