Decreased serum profile of the interleukin-36α in polycystic ovary syndrome
Objective: The aim of this study was to determine the serum adiponectin and interleukin-36 alpha (IL-36α) levels in polycystic ovary syndrome (PCOS), and their relationship with obesity. Materials and methods: This observatory study included 80 PCOS patients and 58 controls. The clinical, biochemica...
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2021
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oai:doaj.org-article:d18354ad8d6544e9adb046c087856c832021-11-18T04:44:41ZDecreased serum profile of the interleukin-36α in polycystic ovary syndrome1028-455910.1016/j.tjog.2021.09.012https://doaj.org/article/d18354ad8d6544e9adb046c087856c832021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1028455921002527https://doaj.org/toc/1028-4559Objective: The aim of this study was to determine the serum adiponectin and interleukin-36 alpha (IL-36α) levels in polycystic ovary syndrome (PCOS), and their relationship with obesity. Materials and methods: This observatory study included 80 PCOS patients and 58 controls. The clinical, biochemical, and hormonal parameters, and serum adiponectin and IL-36α levels of the patients were evaluated. Results: The serum IL-36α levels of the PCOS patients were significantly lower when compared to the control group, despite a similar mean body mass index (BMI) (P = 0.000). The adiponectin levels were significantly lower in the obese PCOS group when compared to the obese control group (P = 0.03). The plasma IL-36α level was positively correlated with adiponectin level, but negatively correlated with the serum LH level (P = 0.000 and P = 0.004, respectively). Using receiver operating characteristic analysis, the cut-off value of IL-36α was calculated as 0.815 for PCOS. In the multiple binary logistic regression analysis, IL-36α (OR [95% CI] 0.432 [0.303, 0.616], P < 0.001) and adiponectin (OR [95% CI] 1.044 [1.005, 1.084], P = 0.028) were determined to be significantly associated with PCOS. Conclusion: A reduced IL-36α level may play a role in the pathogenesis of ovulatory disfunction and insulin resistance in PCOS patients. Further studies are needed to understand the pathogenic and clinical significance of the IL-36 system in PCOS.Semra ErogluElcin Kal CakmakliogullariElsevierarticlePolycystic ovary syndromeObesityInterleukin-36AdiponectinGynecology and obstetricsRG1-991ENTaiwanese Journal of Obstetrics & Gynecology, Vol 60, Iss 6, Pp 1018-1022 (2021) |
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Polycystic ovary syndrome Obesity Interleukin-36 Adiponectin Gynecology and obstetrics RG1-991 |
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Polycystic ovary syndrome Obesity Interleukin-36 Adiponectin Gynecology and obstetrics RG1-991 Semra Eroglu Elcin Kal Cakmakliogullari Decreased serum profile of the interleukin-36α in polycystic ovary syndrome |
description |
Objective: The aim of this study was to determine the serum adiponectin and interleukin-36 alpha (IL-36α) levels in polycystic ovary syndrome (PCOS), and their relationship with obesity. Materials and methods: This observatory study included 80 PCOS patients and 58 controls. The clinical, biochemical, and hormonal parameters, and serum adiponectin and IL-36α levels of the patients were evaluated. Results: The serum IL-36α levels of the PCOS patients were significantly lower when compared to the control group, despite a similar mean body mass index (BMI) (P = 0.000). The adiponectin levels were significantly lower in the obese PCOS group when compared to the obese control group (P = 0.03). The plasma IL-36α level was positively correlated with adiponectin level, but negatively correlated with the serum LH level (P = 0.000 and P = 0.004, respectively). Using receiver operating characteristic analysis, the cut-off value of IL-36α was calculated as 0.815 for PCOS. In the multiple binary logistic regression analysis, IL-36α (OR [95% CI] 0.432 [0.303, 0.616], P < 0.001) and adiponectin (OR [95% CI] 1.044 [1.005, 1.084], P = 0.028) were determined to be significantly associated with PCOS. Conclusion: A reduced IL-36α level may play a role in the pathogenesis of ovulatory disfunction and insulin resistance in PCOS patients. Further studies are needed to understand the pathogenic and clinical significance of the IL-36 system in PCOS. |
format |
article |
author |
Semra Eroglu Elcin Kal Cakmakliogullari |
author_facet |
Semra Eroglu Elcin Kal Cakmakliogullari |
author_sort |
Semra Eroglu |
title |
Decreased serum profile of the interleukin-36α in polycystic ovary syndrome |
title_short |
Decreased serum profile of the interleukin-36α in polycystic ovary syndrome |
title_full |
Decreased serum profile of the interleukin-36α in polycystic ovary syndrome |
title_fullStr |
Decreased serum profile of the interleukin-36α in polycystic ovary syndrome |
title_full_unstemmed |
Decreased serum profile of the interleukin-36α in polycystic ovary syndrome |
title_sort |
decreased serum profile of the interleukin-36α in polycystic ovary syndrome |
publisher |
Elsevier |
publishDate |
2021 |
url |
https://doaj.org/article/d18354ad8d6544e9adb046c087856c83 |
work_keys_str_mv |
AT semraeroglu decreasedserumprofileoftheinterleukin36ainpolycysticovarysyndrome AT elcinkalcakmakliogullari decreasedserumprofileoftheinterleukin36ainpolycysticovarysyndrome |
_version_ |
1718425128628387840 |