Decreased serum profile of the interleukin-36α in polycystic ovary syndrome

Objective: The aim of this study was to determine the serum adiponectin and interleukin-36 alpha (IL-36α) levels in polycystic ovary syndrome (PCOS), and their relationship with obesity. Materials and methods: This observatory study included 80 PCOS patients and 58 controls. The clinical, biochemica...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Semra Eroglu, Elcin Kal Cakmakliogullari
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://doaj.org/article/d18354ad8d6544e9adb046c087856c83
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:d18354ad8d6544e9adb046c087856c83
record_format dspace
spelling oai:doaj.org-article:d18354ad8d6544e9adb046c087856c832021-11-18T04:44:41ZDecreased serum profile of the interleukin-36α in polycystic ovary syndrome1028-455910.1016/j.tjog.2021.09.012https://doaj.org/article/d18354ad8d6544e9adb046c087856c832021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1028455921002527https://doaj.org/toc/1028-4559Objective: The aim of this study was to determine the serum adiponectin and interleukin-36 alpha (IL-36α) levels in polycystic ovary syndrome (PCOS), and their relationship with obesity. Materials and methods: This observatory study included 80 PCOS patients and 58 controls. The clinical, biochemical, and hormonal parameters, and serum adiponectin and IL-36α levels of the patients were evaluated. Results: The serum IL-36α levels of the PCOS patients were significantly lower when compared to the control group, despite a similar mean body mass index (BMI) (P = 0.000). The adiponectin levels were significantly lower in the obese PCOS group when compared to the obese control group (P = 0.03). The plasma IL-36α level was positively correlated with adiponectin level, but negatively correlated with the serum LH level (P = 0.000 and P = 0.004, respectively). Using receiver operating characteristic analysis, the cut-off value of IL-36α was calculated as 0.815 for PCOS. In the multiple binary logistic regression analysis, IL-36α (OR [95% CI] 0.432 [0.303, 0.616], P < 0.001) and adiponectin (OR [95% CI] 1.044 [1.005, 1.084], P = 0.028) were determined to be significantly associated with PCOS. Conclusion: A reduced IL-36α level may play a role in the pathogenesis of ovulatory disfunction and insulin resistance in PCOS patients. Further studies are needed to understand the pathogenic and clinical significance of the IL-36 system in PCOS.Semra ErogluElcin Kal CakmakliogullariElsevierarticlePolycystic ovary syndromeObesityInterleukin-36AdiponectinGynecology and obstetricsRG1-991ENTaiwanese Journal of Obstetrics & Gynecology, Vol 60, Iss 6, Pp 1018-1022 (2021)
institution DOAJ
collection DOAJ
language EN
topic Polycystic ovary syndrome
Obesity
Interleukin-36
Adiponectin
Gynecology and obstetrics
RG1-991
spellingShingle Polycystic ovary syndrome
Obesity
Interleukin-36
Adiponectin
Gynecology and obstetrics
RG1-991
Semra Eroglu
Elcin Kal Cakmakliogullari
Decreased serum profile of the interleukin-36α in polycystic ovary syndrome
description Objective: The aim of this study was to determine the serum adiponectin and interleukin-36 alpha (IL-36α) levels in polycystic ovary syndrome (PCOS), and their relationship with obesity. Materials and methods: This observatory study included 80 PCOS patients and 58 controls. The clinical, biochemical, and hormonal parameters, and serum adiponectin and IL-36α levels of the patients were evaluated. Results: The serum IL-36α levels of the PCOS patients were significantly lower when compared to the control group, despite a similar mean body mass index (BMI) (P = 0.000). The adiponectin levels were significantly lower in the obese PCOS group when compared to the obese control group (P = 0.03). The plasma IL-36α level was positively correlated with adiponectin level, but negatively correlated with the serum LH level (P = 0.000 and P = 0.004, respectively). Using receiver operating characteristic analysis, the cut-off value of IL-36α was calculated as 0.815 for PCOS. In the multiple binary logistic regression analysis, IL-36α (OR [95% CI] 0.432 [0.303, 0.616], P < 0.001) and adiponectin (OR [95% CI] 1.044 [1.005, 1.084], P = 0.028) were determined to be significantly associated with PCOS. Conclusion: A reduced IL-36α level may play a role in the pathogenesis of ovulatory disfunction and insulin resistance in PCOS patients. Further studies are needed to understand the pathogenic and clinical significance of the IL-36 system in PCOS.
format article
author Semra Eroglu
Elcin Kal Cakmakliogullari
author_facet Semra Eroglu
Elcin Kal Cakmakliogullari
author_sort Semra Eroglu
title Decreased serum profile of the interleukin-36α in polycystic ovary syndrome
title_short Decreased serum profile of the interleukin-36α in polycystic ovary syndrome
title_full Decreased serum profile of the interleukin-36α in polycystic ovary syndrome
title_fullStr Decreased serum profile of the interleukin-36α in polycystic ovary syndrome
title_full_unstemmed Decreased serum profile of the interleukin-36α in polycystic ovary syndrome
title_sort decreased serum profile of the interleukin-36α in polycystic ovary syndrome
publisher Elsevier
publishDate 2021
url https://doaj.org/article/d18354ad8d6544e9adb046c087856c83
work_keys_str_mv AT semraeroglu decreasedserumprofileoftheinterleukin36ainpolycysticovarysyndrome
AT elcinkalcakmakliogullari decreasedserumprofileoftheinterleukin36ainpolycysticovarysyndrome
_version_ 1718425128628387840