Endoplasmic reticulum visits highly active spines and prevents runaway potentiation of synapses

In hippocampal pyramidal cells, a subset of dendritic spines contain endoplasmic reticulum (ER). Here, the authors show that ER enters dendritic spines in a non-random manner, during high synaptic activity with the function of limiting synaptic strength.

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Autores principales:	Alberto Perez-Alvarez, Shuting Yin, Christian Schulze, John A. Hammer, Wolfgang Wagner, Thomas G. Oertner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d18389b28e5c4c748bad163e6a7b8cd6
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spelling	oai:doaj.org-article:d18389b28e5c4c748bad163e6a7b8cd62021-12-02T18:37:29ZEndoplasmic reticulum visits highly active spines and prevents runaway potentiation of synapses10.1038/s41467-020-18889-52041-1723https://doaj.org/article/d18389b28e5c4c748bad163e6a7b8cd62020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18889-5https://doaj.org/toc/2041-1723In hippocampal pyramidal cells, a subset of dendritic spines contain endoplasmic reticulum (ER). Here, the authors show that ER enters dendritic spines in a non-random manner, during high synaptic activity with the function of limiting synaptic strength.Alberto Perez-AlvarezShuting YinChristian SchulzeJohn A. HammerWolfgang WagnerThomas G. OertnerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alberto Perez-Alvarez Shuting Yin Christian Schulze John A. Hammer Wolfgang Wagner Thomas G. Oertner Endoplasmic reticulum visits highly active spines and prevents runaway potentiation of synapses
description	In hippocampal pyramidal cells, a subset of dendritic spines contain endoplasmic reticulum (ER). Here, the authors show that ER enters dendritic spines in a non-random manner, during high synaptic activity with the function of limiting synaptic strength.
format	article
author	Alberto Perez-Alvarez Shuting Yin Christian Schulze John A. Hammer Wolfgang Wagner Thomas G. Oertner
author_facet	Alberto Perez-Alvarez Shuting Yin Christian Schulze John A. Hammer Wolfgang Wagner Thomas G. Oertner
author_sort	Alberto Perez-Alvarez
title	Endoplasmic reticulum visits highly active spines and prevents runaway potentiation of synapses
title_short	Endoplasmic reticulum visits highly active spines and prevents runaway potentiation of synapses
title_full	Endoplasmic reticulum visits highly active spines and prevents runaway potentiation of synapses
title_fullStr	Endoplasmic reticulum visits highly active spines and prevents runaway potentiation of synapses
title_full_unstemmed	Endoplasmic reticulum visits highly active spines and prevents runaway potentiation of synapses
title_sort	endoplasmic reticulum visits highly active spines and prevents runaway potentiation of synapses
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d18389b28e5c4c748bad163e6a7b8cd6
work_keys_str_mv	AT albertoperezalvarez endoplasmicreticulumvisitshighlyactivespinesandpreventsrunawaypotentiationofsynapses AT shutingyin endoplasmicreticulumvisitshighlyactivespinesandpreventsrunawaypotentiationofsynapses AT christianschulze endoplasmicreticulumvisitshighlyactivespinesandpreventsrunawaypotentiationofsynapses AT johnahammer endoplasmicreticulumvisitshighlyactivespinesandpreventsrunawaypotentiationofsynapses AT wolfgangwagner endoplasmicreticulumvisitshighlyactivespinesandpreventsrunawaypotentiationofsynapses AT thomasgoertner endoplasmicreticulumvisitshighlyactivespinesandpreventsrunawaypotentiationofsynapses
_version_	1718377827919724544

Endoplasmic reticulum visits highly active spines and prevents runaway potentiation of synapses

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