On the Role of the Immunoproteasome in Protein Homeostasis

Numerous cellular processes are controlled by the proteasome, a multicatalytic protease in the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation. The immunoproteasome is a special type of proteasome which is inducible under inflammatory conditions and constitutively...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Michael Basler, Marcus Groettrup
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	proteasome immunoproteasome ubiquitin ubiquitin–proteasome system (UPS) protein degradation protein homeostasis Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d186bba6ada945bd96857d4663c9a71c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d186bba6ada945bd96857d4663c9a71c
record_format	dspace
spelling	oai:doaj.org-article:d186bba6ada945bd96857d4663c9a71c2021-11-25T17:12:58ZOn the Role of the Immunoproteasome in Protein Homeostasis10.3390/cells101132162073-4409https://doaj.org/article/d186bba6ada945bd96857d4663c9a71c2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3216https://doaj.org/toc/2073-4409Numerous cellular processes are controlled by the proteasome, a multicatalytic protease in the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation. The immunoproteasome is a special type of proteasome which is inducible under inflammatory conditions and constitutively expressed in hematopoietic cells. MECL-1 (β2i), LMP2 (β1i), and LMP7 (β5i) are the proteolytically active subunits of the immunoproteasome (IP), which is known to shape the antigenic repertoire presented on major histocompatibility complex (MHC) class I molecules. Furthermore, the immunoproteasome is involved in T cell expansion and inflammatory diseases. In recent years, targeting the immunoproteasome in cancer, autoimmune diseases, and transplantation proved to be therapeutically effective in preclinical animal models. However, the prime function of standard proteasomes and immunoproteasomes is the control of protein homeostasis in cells. To maintain protein homeostasis in cells, proteasomes remove proteins which are not properly folded, which are damaged by stress conditions such as reactive oxygen species formation, or which have to be degraded on the basis of regular protein turnover. In this review we summarize the latest insights on how the immunoproteasome influences protein homeostasis.Michael BaslerMarcus GroettrupMDPI AGarticleproteasomeimmunoproteasomeubiquitinubiquitin–proteasome system (UPS)protein degradationprotein homeostasisBiology (General)QH301-705.5ENCells, Vol 10, Iss 3216, p 3216 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	proteasome immunoproteasome ubiquitin ubiquitin–proteasome system (UPS) protein degradation protein homeostasis Biology (General) QH301-705.5
spellingShingle	proteasome immunoproteasome ubiquitin ubiquitin–proteasome system (UPS) protein degradation protein homeostasis Biology (General) QH301-705.5 Michael Basler Marcus Groettrup On the Role of the Immunoproteasome in Protein Homeostasis
description	Numerous cellular processes are controlled by the proteasome, a multicatalytic protease in the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation. The immunoproteasome is a special type of proteasome which is inducible under inflammatory conditions and constitutively expressed in hematopoietic cells. MECL-1 (β2i), LMP2 (β1i), and LMP7 (β5i) are the proteolytically active subunits of the immunoproteasome (IP), which is known to shape the antigenic repertoire presented on major histocompatibility complex (MHC) class I molecules. Furthermore, the immunoproteasome is involved in T cell expansion and inflammatory diseases. In recent years, targeting the immunoproteasome in cancer, autoimmune diseases, and transplantation proved to be therapeutically effective in preclinical animal models. However, the prime function of standard proteasomes and immunoproteasomes is the control of protein homeostasis in cells. To maintain protein homeostasis in cells, proteasomes remove proteins which are not properly folded, which are damaged by stress conditions such as reactive oxygen species formation, or which have to be degraded on the basis of regular protein turnover. In this review we summarize the latest insights on how the immunoproteasome influences protein homeostasis.
format	article
author	Michael Basler Marcus Groettrup
author_facet	Michael Basler Marcus Groettrup
author_sort	Michael Basler
title	On the Role of the Immunoproteasome in Protein Homeostasis
title_short	On the Role of the Immunoproteasome in Protein Homeostasis
title_full	On the Role of the Immunoproteasome in Protein Homeostasis
title_fullStr	On the Role of the Immunoproteasome in Protein Homeostasis
title_full_unstemmed	On the Role of the Immunoproteasome in Protein Homeostasis
title_sort	on the role of the immunoproteasome in protein homeostasis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d186bba6ada945bd96857d4663c9a71c
work_keys_str_mv	AT michaelbasler ontheroleoftheimmunoproteasomeinproteinhomeostasis AT marcusgroettrup ontheroleoftheimmunoproteasomeinproteinhomeostasis
_version_	1718412619149213696

On the Role of the Immunoproteasome in Protein Homeostasis

Ejemplares similares