Antibiotic resistance pattern of Klebsiella pneumoniae in obtained samples from Ziaee Hospital of Ardakan, Yazd, Iran during 2016 to 2017

Background: In recent years, due to the inappropriate use of antibiotics, drug resistance has increased in gram negative bacilli, including Klebsiella pneumoniae. Drug resistance is associated with an increase in mortality and therapeutic costs. Therefore, determination of an antibiotic resistance p...

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Autores principales:	Jamshid Ayatollahi, Mohammad Sharifyazdi, Razieh Fadakarfard, Seyed Hossein Shahcheraghi
Formato:	article
Lenguaje:	EN
Publicado:	Emergency Department of Hospital San Pedro (Logroño, Spain) 2020
Materias:	klebsiella resistance antibiotic Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d18ba20d476f4f048c86140bffe8783e
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spelling	oai:doaj.org-article:d18ba20d476f4f048c86140bffe8783e2021-12-02T19:14:48ZAntibiotic resistance pattern of Klebsiella pneumoniae in obtained samples from Ziaee Hospital of Ardakan, Yazd, Iran during 2016 to 201710.5281/zenodo.36981802695-5075https://doaj.org/article/d18ba20d476f4f048c86140bffe8783e2020-03-01T00:00:00Zhttps://doi.org/10.5281/zenodo.3698180https://doaj.org/toc/2695-5075Background: In recent years, due to the inappropriate use of antibiotics, drug resistance has increased in gram negative bacilli, including Klebsiella pneumoniae. Drug resistance is associated with an increase in mortality and therapeutic costs. Therefore, determination of an antibiotic resistance pattern for choosing the appropriate treatment for infections caused by this bacterium seems necessary. This study was conducted to determine the antibiotic resistance pattern of Klebsiella pneumoniae species isolated from patients referring to Ziaee Hospital in Ardakan in 2016-2017. Materials and Methods: For this descriptive-analytic study, all positive cultures of Klebsiella pneumoniae in patients referred to Ziaee Hospital in Ardakan during 2016 to 2017, were evaluated. Antibiotic resistance patterns of the samples were determined by the standard method of propagation of the disk from 12 different antibiotics and data analyzed by SPSS 21 software. Results and discussions: The results of this study, which were performed on 75 samples, showed that 22 (29.3%) were male and 53 (70.7%) were female. Klebsiella's resistance to clarithromycin was 100%, but was 100% susceptible to amikacin. The percentage of Klebsiella's resistance to ampicillin was 78.3%, cefalotin 75%, cotrimoxazole 43.9%, ceftriaxone 32%, ciprofloxacin 30.9%, cefotaxime 24%, and ampicillin 20%. The highest sensitivity of Klebsiella pneumoniae for antibiotics was 100% for amikacin, 82.8% for meropenem and 82% for cefepime. Due to the high prevalence of resistance in Klebsiella samples, there is a need for strict measures in the administration of antibiotics. Antibiotic resistance can also be reduced by choosing the appropriate antibiotic for treatment and by taking antibiotic susceptibility tests.Jamshid AyatollahiMohammad SharifyazdiRazieh FadakarfardSeyed Hossein ShahcheraghiEmergency Department of Hospital San Pedro (Logroño, Spain)articleklebsiellaresistanceantibioticMedicine (General)R5-920ENIberoamerican Journal of Medicine, Vol 2, Iss 2, Pp 32-36 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	klebsiella resistance antibiotic Medicine (General) R5-920
spellingShingle	klebsiella resistance antibiotic Medicine (General) R5-920 Jamshid Ayatollahi Mohammad Sharifyazdi Razieh Fadakarfard Seyed Hossein Shahcheraghi Antibiotic resistance pattern of Klebsiella pneumoniae in obtained samples from Ziaee Hospital of Ardakan, Yazd, Iran during 2016 to 2017
description	Background: In recent years, due to the inappropriate use of antibiotics, drug resistance has increased in gram negative bacilli, including Klebsiella pneumoniae. Drug resistance is associated with an increase in mortality and therapeutic costs. Therefore, determination of an antibiotic resistance pattern for choosing the appropriate treatment for infections caused by this bacterium seems necessary. This study was conducted to determine the antibiotic resistance pattern of Klebsiella pneumoniae species isolated from patients referring to Ziaee Hospital in Ardakan in 2016-2017. Materials and Methods: For this descriptive-analytic study, all positive cultures of Klebsiella pneumoniae in patients referred to Ziaee Hospital in Ardakan during 2016 to 2017, were evaluated. Antibiotic resistance patterns of the samples were determined by the standard method of propagation of the disk from 12 different antibiotics and data analyzed by SPSS 21 software. Results and discussions: The results of this study, which were performed on 75 samples, showed that 22 (29.3%) were male and 53 (70.7%) were female. Klebsiella's resistance to clarithromycin was 100%, but was 100% susceptible to amikacin. The percentage of Klebsiella's resistance to ampicillin was 78.3%, cefalotin 75%, cotrimoxazole 43.9%, ceftriaxone 32%, ciprofloxacin 30.9%, cefotaxime 24%, and ampicillin 20%. The highest sensitivity of Klebsiella pneumoniae for antibiotics was 100% for amikacin, 82.8% for meropenem and 82% for cefepime. Due to the high prevalence of resistance in Klebsiella samples, there is a need for strict measures in the administration of antibiotics. Antibiotic resistance can also be reduced by choosing the appropriate antibiotic for treatment and by taking antibiotic susceptibility tests.
format	article
author	Jamshid Ayatollahi Mohammad Sharifyazdi Razieh Fadakarfard Seyed Hossein Shahcheraghi
author_facet	Jamshid Ayatollahi Mohammad Sharifyazdi Razieh Fadakarfard Seyed Hossein Shahcheraghi
author_sort	Jamshid Ayatollahi
title	Antibiotic resistance pattern of Klebsiella pneumoniae in obtained samples from Ziaee Hospital of Ardakan, Yazd, Iran during 2016 to 2017
title_short	Antibiotic resistance pattern of Klebsiella pneumoniae in obtained samples from Ziaee Hospital of Ardakan, Yazd, Iran during 2016 to 2017
title_full	Antibiotic resistance pattern of Klebsiella pneumoniae in obtained samples from Ziaee Hospital of Ardakan, Yazd, Iran during 2016 to 2017
title_fullStr	Antibiotic resistance pattern of Klebsiella pneumoniae in obtained samples from Ziaee Hospital of Ardakan, Yazd, Iran during 2016 to 2017
title_full_unstemmed	Antibiotic resistance pattern of Klebsiella pneumoniae in obtained samples from Ziaee Hospital of Ardakan, Yazd, Iran during 2016 to 2017
title_sort	antibiotic resistance pattern of klebsiella pneumoniae in obtained samples from ziaee hospital of ardakan, yazd, iran during 2016 to 2017
publisher	Emergency Department of Hospital San Pedro (Logroño, Spain)
publishDate	2020
url	https://doaj.org/article/d18ba20d476f4f048c86140bffe8783e
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_version_	1718376998723649536

Antibiotic resistance pattern of Klebsiella pneumoniae in obtained samples from Ziaee Hospital of Ardakan, Yazd, Iran during 2016 to 2017

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