The Ketogenic Diet: Safety, Morbidity, and Mortality

In normal daily diet consisting of 52-55% carbohydrate, 32-34% fat, and 14-18% protein, a couple hours following meal and absorption there is abundant fuel supply particularly from glucose oxidation in most tissues (Kathleen M Botham and Mayes, 2015; USDA, 2015). Conversely, in ketosis condition, mo...

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Autor principal:	Taufiqurrachman Nasihun
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Sultan Agung Semarang 2019
Materias:	the ketogenic diet safety morbidity mortality Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d18cbd4dde4b47fa9fb0cfc6cba5ee9a
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spelling	oai:doaj.org-article:d18cbd4dde4b47fa9fb0cfc6cba5ee9a2021-11-25T13:16:18ZThe Ketogenic Diet: Safety, Morbidity, and Mortality2085-15452339-093Xhttps://doaj.org/article/d18cbd4dde4b47fa9fb0cfc6cba5ee9a2019-07-01T00:00:00Zhttp://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/7893https://doaj.org/toc/2085-1545https://doaj.org/toc/2339-093XIn normal daily diet consisting of 52-55% carbohydrate, 32-34% fat, and 14-18% protein, a couple hours following meal and absorption there is abundant fuel supply particularly from glucose oxidation in most tissues (Kathleen M Botham and Mayes, 2015; USDA, 2015). Conversely, in ketosis condition, most tissues replace its energy requirement from glucose to ketone bodies resulting from hepatic ketogenesis (Cervenka and Kossoff, 2013; Mcdonald and Cervenka, 2017). In extra hepatic tissues, adenosine triphosphate (ATP) is synthesized through revert back of acetoacetate to acetoacetyl-CoA catalyzed by succinyl-CoA-acetoacetate CoA transferase. By this reaction acetoacetyl-CoA is split into two acetyl-CoA catalyzed by thiolase and then inserted into Kreb’s cycle to form ATP. Acetoacetate and b hydroxybutyrate are also able to traverse blood brain barrier and metabolized by cellular brain into ATP and used as energy also postulated as anticonvulsant (Freeman et al., 2007; J. L. Gamble et al., 1923). Moreover, when ketone bodies in circulation are increased, oxidation of ketone bodies also raised until saturation of the pathway is achieved at 12 mmol/L concentration (Kathleen M. Botham and Mayes, 2015). Concern to the energy synthesis, acetoacetate and 3-b hydroxybutyrate are the prominent ketone bodies which are readily oxidized in extra-hepatic tissues. Whilst acetone have not metabolic function and in large extent is volatilized through the lung marked by breathe odor (Kathleen M. Botham and Mayes, 2015; Paoli, 2014). Ketosis is also able to suppress hunger feeling and appetite, therefore potential to be a good regulator of the body’s calorie intake (Dashti et al., 2004). However, ketosis which is induced by ketogenic diet (KD), in the long term, its safety, morbidity, and mortality remain inconclusive.Taufiqurrachman NasihunUniversitas Sultan Agung Semarangarticlethe ketogenic dietsafetymorbiditymortalityMedicine (General)R5-920ENSains Medika, Vol 10, Iss 1, Pp 1-4 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	the ketogenic diet safety morbidity mortality Medicine (General) R5-920
spellingShingle	the ketogenic diet safety morbidity mortality Medicine (General) R5-920 Taufiqurrachman Nasihun The Ketogenic Diet: Safety, Morbidity, and Mortality
description	In normal daily diet consisting of 52-55% carbohydrate, 32-34% fat, and 14-18% protein, a couple hours following meal and absorption there is abundant fuel supply particularly from glucose oxidation in most tissues (Kathleen M Botham and Mayes, 2015; USDA, 2015). Conversely, in ketosis condition, most tissues replace its energy requirement from glucose to ketone bodies resulting from hepatic ketogenesis (Cervenka and Kossoff, 2013; Mcdonald and Cervenka, 2017). In extra hepatic tissues, adenosine triphosphate (ATP) is synthesized through revert back of acetoacetate to acetoacetyl-CoA catalyzed by succinyl-CoA-acetoacetate CoA transferase. By this reaction acetoacetyl-CoA is split into two acetyl-CoA catalyzed by thiolase and then inserted into Kreb’s cycle to form ATP. Acetoacetate and b hydroxybutyrate are also able to traverse blood brain barrier and metabolized by cellular brain into ATP and used as energy also postulated as anticonvulsant (Freeman et al., 2007; J. L. Gamble et al., 1923). Moreover, when ketone bodies in circulation are increased, oxidation of ketone bodies also raised until saturation of the pathway is achieved at 12 mmol/L concentration (Kathleen M. Botham and Mayes, 2015). Concern to the energy synthesis, acetoacetate and 3-b hydroxybutyrate are the prominent ketone bodies which are readily oxidized in extra-hepatic tissues. Whilst acetone have not metabolic function and in large extent is volatilized through the lung marked by breathe odor (Kathleen M. Botham and Mayes, 2015; Paoli, 2014). Ketosis is also able to suppress hunger feeling and appetite, therefore potential to be a good regulator of the body’s calorie intake (Dashti et al., 2004). However, ketosis which is induced by ketogenic diet (KD), in the long term, its safety, morbidity, and mortality remain inconclusive.
format	article
author	Taufiqurrachman Nasihun
author_facet	Taufiqurrachman Nasihun
author_sort	Taufiqurrachman Nasihun
title	The Ketogenic Diet: Safety, Morbidity, and Mortality
title_short	The Ketogenic Diet: Safety, Morbidity, and Mortality
title_full	The Ketogenic Diet: Safety, Morbidity, and Mortality
title_fullStr	The Ketogenic Diet: Safety, Morbidity, and Mortality
title_full_unstemmed	The Ketogenic Diet: Safety, Morbidity, and Mortality
title_sort	ketogenic diet: safety, morbidity, and mortality
publisher	Universitas Sultan Agung Semarang
publishDate	2019
url	https://doaj.org/article/d18cbd4dde4b47fa9fb0cfc6cba5ee9a
work_keys_str_mv	AT taufiqurrachmannasihun theketogenicdietsafetymorbidityandmortality AT taufiqurrachmannasihun ketogenicdietsafetymorbidityandmortality
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The Ketogenic Diet: Safety, Morbidity, and Mortality

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