ANALYSIS OF ESTROGEN RECEPTOR (ER) AND PROGESTRONE RECEPTOR (PR) EXPRESSION IN SURFACE EPITHELIAL TUMORS OF OVARY AND ITS CORRELATION WITH THEIR CLINICAL STAGE

Objective: To evaluate ER and PR expression in epithelial ovarian cancers (EOC) and to determine its association with clinical stage. Study Design: Cross sectional study. Place and Duration of Study: Histopathology department, Armed Forces Institute of Pathology (AFIP) Rawalpindi, from Mar to Oc...

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Autores principales:	Madeeha Anwar, Muhammad Asif, Riaz Ahmed, Muhammad Tahir Khadim, Hamza Mansur, Rabia Ahmed
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2018
Materias:	clinical stage estrogen receptor immunohistochemistry ovarian cancer Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d18d852fd4b44881abb10e2ff525e85f
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spelling	oai:doaj.org-article:d18d852fd4b44881abb10e2ff525e85f2021-12-01T03:16:33ZANALYSIS OF ESTROGEN RECEPTOR (ER) AND PROGESTRONE RECEPTOR (PR) EXPRESSION IN SURFACE EPITHELIAL TUMORS OF OVARY AND ITS CORRELATION WITH THEIR CLINICAL STAGE0030-96482411-8842https://doaj.org/article/d18d852fd4b44881abb10e2ff525e85f2018-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2276/1973https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To evaluate ER and PR expression in epithelial ovarian cancers (EOC) and to determine its association with clinical stage. Study Design: Cross sectional study. Place and Duration of Study: Histopathology department, Armed Forces Institute of Pathology (AFIP) Rawalpindi, from Mar to Oct 2017. Material and Methods: A total of thirty three (n=33) histologically confirmed EOCs were analyzed. ER and PR expression status was assessed by immunohistochemistry using Allred scoring system and was compared with the clinical stage defined by The International Federation of Gynecology and Obstetrics (FIGO) staging system. Results: A total of thirty three (n=33) females were enrolled. Mean age of the study females was 50.8 ± 12.9 years. Most frequent histologic type was serous carcinoma (SC) 60.6% (n=20) followed by mucinous carcinoma (MC) 15.2% (n=5), endometrioid carcinoma (EC) 9.1% (n=3), clear cell carcinoma (CC) 9.1% (n=3), Brenner tumor (MBT) 3% (n=1) and seromucinous carcinoma (SMC) 3% (n=1). Most patients were in clinical stage I 61% (n=20) followed by stage II 24%, (n=8) and stage III 15% (n=5). Among SC, 90.0% (n=18/20) were ER and 65% (n=13/20) were PR-positive. All MC and CC were ER/PR negative. Two of the three ECs were ER and one was PR-positive. Higher percentage of stage I tumors exhibited ER 65% (n=13/20) and PR 45% (n=9/20) positive status (p>0.5). The correlation was very weak positive between clinical stages and both ER and PR scores (Allred) r=0.11 and 0.15 respectively p>0.05. Conclusion: Higher percentages of stage I tumors exhibited ER and PR positive status yet not statistically significant from stage II/III. Estimation of ER and PR receptor status may help to select the women with ovarian malignancy for hormonal therapy, which is more likely to improve the response rate.Madeeha AnwarMuhammad AsifRiaz AhmedMuhammad Tahir KhadimHamza MansurRabia AhmedArmy Medical College Rawalpindiarticleclinical stageestrogen receptorimmunohistochemistryovarian cancerMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 68, Iss 5, Pp 1121-1125 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	clinical stage estrogen receptor immunohistochemistry ovarian cancer Medicine R Medicine (General) R5-920
spellingShingle	clinical stage estrogen receptor immunohistochemistry ovarian cancer Medicine R Medicine (General) R5-920 Madeeha Anwar Muhammad Asif Riaz Ahmed Muhammad Tahir Khadim Hamza Mansur Rabia Ahmed ANALYSIS OF ESTROGEN RECEPTOR (ER) AND PROGESTRONE RECEPTOR (PR) EXPRESSION IN SURFACE EPITHELIAL TUMORS OF OVARY AND ITS CORRELATION WITH THEIR CLINICAL STAGE
description	Objective: To evaluate ER and PR expression in epithelial ovarian cancers (EOC) and to determine its association with clinical stage. Study Design: Cross sectional study. Place and Duration of Study: Histopathology department, Armed Forces Institute of Pathology (AFIP) Rawalpindi, from Mar to Oct 2017. Material and Methods: A total of thirty three (n=33) histologically confirmed EOCs were analyzed. ER and PR expression status was assessed by immunohistochemistry using Allred scoring system and was compared with the clinical stage defined by The International Federation of Gynecology and Obstetrics (FIGO) staging system. Results: A total of thirty three (n=33) females were enrolled. Mean age of the study females was 50.8 ± 12.9 years. Most frequent histologic type was serous carcinoma (SC) 60.6% (n=20) followed by mucinous carcinoma (MC) 15.2% (n=5), endometrioid carcinoma (EC) 9.1% (n=3), clear cell carcinoma (CC) 9.1% (n=3), Brenner tumor (MBT) 3% (n=1) and seromucinous carcinoma (SMC) 3% (n=1). Most patients were in clinical stage I 61% (n=20) followed by stage II 24%, (n=8) and stage III 15% (n=5). Among SC, 90.0% (n=18/20) were ER and 65% (n=13/20) were PR-positive. All MC and CC were ER/PR negative. Two of the three ECs were ER and one was PR-positive. Higher percentage of stage I tumors exhibited ER 65% (n=13/20) and PR 45% (n=9/20) positive status (p>0.5). The correlation was very weak positive between clinical stages and both ER and PR scores (Allred) r=0.11 and 0.15 respectively p>0.05. Conclusion: Higher percentages of stage I tumors exhibited ER and PR positive status yet not statistically significant from stage II/III. Estimation of ER and PR receptor status may help to select the women with ovarian malignancy for hormonal therapy, which is more likely to improve the response rate.
format	article
author	Madeeha Anwar Muhammad Asif Riaz Ahmed Muhammad Tahir Khadim Hamza Mansur Rabia Ahmed
author_facet	Madeeha Anwar Muhammad Asif Riaz Ahmed Muhammad Tahir Khadim Hamza Mansur Rabia Ahmed
author_sort	Madeeha Anwar
title	ANALYSIS OF ESTROGEN RECEPTOR (ER) AND PROGESTRONE RECEPTOR (PR) EXPRESSION IN SURFACE EPITHELIAL TUMORS OF OVARY AND ITS CORRELATION WITH THEIR CLINICAL STAGE
title_short	ANALYSIS OF ESTROGEN RECEPTOR (ER) AND PROGESTRONE RECEPTOR (PR) EXPRESSION IN SURFACE EPITHELIAL TUMORS OF OVARY AND ITS CORRELATION WITH THEIR CLINICAL STAGE
title_full	ANALYSIS OF ESTROGEN RECEPTOR (ER) AND PROGESTRONE RECEPTOR (PR) EXPRESSION IN SURFACE EPITHELIAL TUMORS OF OVARY AND ITS CORRELATION WITH THEIR CLINICAL STAGE
title_fullStr	ANALYSIS OF ESTROGEN RECEPTOR (ER) AND PROGESTRONE RECEPTOR (PR) EXPRESSION IN SURFACE EPITHELIAL TUMORS OF OVARY AND ITS CORRELATION WITH THEIR CLINICAL STAGE
title_full_unstemmed	ANALYSIS OF ESTROGEN RECEPTOR (ER) AND PROGESTRONE RECEPTOR (PR) EXPRESSION IN SURFACE EPITHELIAL TUMORS OF OVARY AND ITS CORRELATION WITH THEIR CLINICAL STAGE
title_sort	analysis of estrogen receptor (er) and progestrone receptor (pr) expression in surface epithelial tumors of ovary and its correlation with their clinical stage
publisher	Army Medical College Rawalpindi
publishDate	2018
url	https://doaj.org/article/d18d852fd4b44881abb10e2ff525e85f
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ANALYSIS OF ESTROGEN RECEPTOR (ER) AND PROGESTRONE RECEPTOR (PR) EXPRESSION IN SURFACE EPITHELIAL TUMORS OF OVARY AND ITS CORRELATION WITH THEIR CLINICAL STAGE

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