Effects of zinc and multimineral vitamin supplementation on glycemic and lipid control in adult diabetes

Priyanka Gunasekara1, Manjula Hettiarachchi2, Chandrani Liyanage2, Sarath Lekamwasam21Coronary Care Unit, Teaching Hospital, Karapitiya, Galle, Sri Lanka; 2Faculty of Medicine, University of Ruhuna, Galle, Sri LankaAims: To evaluate the effects of zinc with or without other antioxidants on blood glu...

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Autores principales:	Priyanka Gunasekara, Manjula Hettiarachchi, Chandrani Liyanage, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/d18e7d057d0b441e827bd192d59e1bc0
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spelling	oai:doaj.org-article:d18e7d057d0b441e827bd192d59e1bc02021-12-02T03:40:35ZEffects of zinc and multimineral vitamin supplementation on glycemic and lipid control in adult diabetes1178-7007https://doaj.org/article/d18e7d057d0b441e827bd192d59e1bc02011-01-01T00:00:00Zhttp://www.dovepress.com/effects-of-zinc-and-multimineral-vitamin-supplementation-on-glycemic-a-a6145https://doaj.org/toc/1178-7007Priyanka Gunasekara1, Manjula Hettiarachchi2, Chandrani Liyanage2, Sarath Lekamwasam21Coronary Care Unit, Teaching Hospital, Karapitiya, Galle, Sri Lanka; 2Faculty of Medicine, University of Ruhuna, Galle, Sri LankaAims: To evaluate the effects of zinc with or without other antioxidants on blood glucose, lipid profile, and serum creatinine in adult diabetics on long-term follow-up.Materials and methods: Patients (n = 96) were randomly allocated to three groups: group A (n = 29) was supplemented with oral zinc sulfate (22 mg/day) and multivitamin/mineral (zinc+MVM) preparation; group B (n = 31) was given the same preparation without zinc (MVM); and group C (n = 36) was given a matching placebo for a period of 4 months in a single-blinded study. Blood samples were taken at baseline and after 4 months of supplementation to assess blood glucose (fasting and postprandial) and glycosylated hemoglobin (HbA1C%) and serum levels of zinc, creatinine, and lipids.Results: The zinc+MVM group had a mean change of fasting blood sugar -0.33 mmol/L (standard error of the mean 0.21 mmol/L) and was significant (P = 0.05) when compared with the other two groups (mean change in the MVM group +0.19 (0.31) mmol/L and +0.43 (0.23) mmol/L in the control group, respectively). The HbA1C% level reduced significantly, irrespective of the baseline level, in zinc+MVM-supplemented individuals. In the other two groups, the change of HbA1C% level was not significant. Serum lipid levels reduced significantly in the zinc+MVM and MVM groups.Conclusions: Zinc+MVM supplementation showed beneficial effects in the metabolic control of adult diabetics in addition to elevating their serum zinc level. Zinc supplementation improved glycemic control measured by HbA1C% and fasting and postprandial glucose. Furthermore, zinc supplementation lowered serum cholesterol and cholesterol/high-density lipoprotein ratio.Keywords: zinc, multivitamin mineral supplementation, diabetes, glycemic control Priyanka GunasekaraManjula HettiarachchiChandrani Liyanageet alDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2011, Iss default, Pp 53-60 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Priyanka Gunasekara Manjula Hettiarachchi Chandrani Liyanage et al Effects of zinc and multimineral vitamin supplementation on glycemic and lipid control in adult diabetes
description	Priyanka Gunasekara1, Manjula Hettiarachchi2, Chandrani Liyanage2, Sarath Lekamwasam21Coronary Care Unit, Teaching Hospital, Karapitiya, Galle, Sri Lanka; 2Faculty of Medicine, University of Ruhuna, Galle, Sri LankaAims: To evaluate the effects of zinc with or without other antioxidants on blood glucose, lipid profile, and serum creatinine in adult diabetics on long-term follow-up.Materials and methods: Patients (n = 96) were randomly allocated to three groups: group A (n = 29) was supplemented with oral zinc sulfate (22 mg/day) and multivitamin/mineral (zinc+MVM) preparation; group B (n = 31) was given the same preparation without zinc (MVM); and group C (n = 36) was given a matching placebo for a period of 4 months in a single-blinded study. Blood samples were taken at baseline and after 4 months of supplementation to assess blood glucose (fasting and postprandial) and glycosylated hemoglobin (HbA1C%) and serum levels of zinc, creatinine, and lipids.Results: The zinc+MVM group had a mean change of fasting blood sugar -0.33 mmol/L (standard error of the mean 0.21 mmol/L) and was significant (P = 0.05) when compared with the other two groups (mean change in the MVM group +0.19 (0.31) mmol/L and +0.43 (0.23) mmol/L in the control group, respectively). The HbA1C% level reduced significantly, irrespective of the baseline level, in zinc+MVM-supplemented individuals. In the other two groups, the change of HbA1C% level was not significant. Serum lipid levels reduced significantly in the zinc+MVM and MVM groups.Conclusions: Zinc+MVM supplementation showed beneficial effects in the metabolic control of adult diabetics in addition to elevating their serum zinc level. Zinc supplementation improved glycemic control measured by HbA1C% and fasting and postprandial glucose. Furthermore, zinc supplementation lowered serum cholesterol and cholesterol/high-density lipoprotein ratio.Keywords: zinc, multivitamin mineral supplementation, diabetes, glycemic control
format	article
author	Priyanka Gunasekara Manjula Hettiarachchi Chandrani Liyanage et al
author_facet	Priyanka Gunasekara Manjula Hettiarachchi Chandrani Liyanage et al
author_sort	Priyanka Gunasekara
title	Effects of zinc and multimineral vitamin supplementation on glycemic and lipid control in adult diabetes
title_short	Effects of zinc and multimineral vitamin supplementation on glycemic and lipid control in adult diabetes
title_full	Effects of zinc and multimineral vitamin supplementation on glycemic and lipid control in adult diabetes
title_fullStr	Effects of zinc and multimineral vitamin supplementation on glycemic and lipid control in adult diabetes
title_full_unstemmed	Effects of zinc and multimineral vitamin supplementation on glycemic and lipid control in adult diabetes
title_sort	effects of zinc and multimineral vitamin supplementation on glycemic and lipid control in adult diabetes
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/d18e7d057d0b441e827bd192d59e1bc0
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Effects of zinc and multimineral vitamin supplementation on glycemic and lipid control in adult diabetes

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