Clinical features and disease severity in an Iranian population of inpatients with COVID-19
Abstract Coronavirus disease 2019 (COVID-19) can present with a variety of symptoms. Severity of the disease may be associated with several factors. Here, we review clinical features of COVID-19 inpatients with different severities. This cross-sectional study was performed in Imam Reza hospital, Mas...
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2021
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oai:doaj.org-article:d1905cf2744a407b992061fe7c9be45b2021-12-02T16:45:31ZClinical features and disease severity in an Iranian population of inpatients with COVID-1910.1038/s41598-021-87917-12045-2322https://doaj.org/article/d1905cf2744a407b992061fe7c9be45b2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87917-1https://doaj.org/toc/2045-2322Abstract Coronavirus disease 2019 (COVID-19) can present with a variety of symptoms. Severity of the disease may be associated with several factors. Here, we review clinical features of COVID-19 inpatients with different severities. This cross-sectional study was performed in Imam Reza hospital, Mashhad, Iran, during February–April 2020. COVID-19 patients with typical computed tomography (CT) patterns and/or positive reverse-transcriptase polymerase chain reaction (RT-PCR) were included. The patients were classified into three groups of moderate, severe, and critical based on disease severity. Demographic, clinical, laboratory, and radiologic findings were collected and compared. P < 0.05 was considered statistically significant. Overall, 200 patients with mean age of 69.75 ± 6.39 years, of whom 82 (41%) were female were studied. Disease was severe/critical in the majority of patients (167, 83.5%). Disease severity was significantly associated with age, malignant comorbidities, dyspnea, nausea/vomiting, confusion, respiratory rate, pulse rate, O2 saturation, extent of CT involvement, serum C-reactive protein (CRP), pH, pO2, and aspartate transaminase (P < 0.05). Moreover, complications including shock, coagulopathy, acidosis, sepsis, acute respiratory distress syndrome (ARDS), intensive care unit (ICU) admission, and intubation were significantly higher in patients with higher severities (P < 0.05). O2 saturation, nausea/vomiting, and extent of lung CT involvement were independent predictors of severe/critical COVID-19 (OR 0.342, 45.93, and 25.48, respectively; P < 0.05). Our results indicate O2 saturation, nausea/vomiting, and extent of lung CT involvement as independent predictors of severe COVID-19 conditions. Serum CRP levels and pO2 were also considerably higher patients with higher severity and can be used along with other factors to predict severe disease in COVID-19 patients.Shima NabaviZahra JavidarabshahiAbolghasem AllahyariMohammad RamezaniMohsen Seddigh-ShamsiSahar RavanshadMina AkbariRadFarnoosh EbrahimzadehShohre KhatamiMaryam EmadzadehNeda SaeedianAhmadreza ZarifianMaryam MiriFariba RezaeetalabSepide HejaziReza BasiriMahnaz MozdourianNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
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Medicine R Science Q Shima Nabavi Zahra Javidarabshahi Abolghasem Allahyari Mohammad Ramezani Mohsen Seddigh-Shamsi Sahar Ravanshad Mina AkbariRad Farnoosh Ebrahimzadeh Shohre Khatami Maryam Emadzadeh Neda Saeedian Ahmadreza Zarifian Maryam Miri Fariba Rezaeetalab Sepide Hejazi Reza Basiri Mahnaz Mozdourian Clinical features and disease severity in an Iranian population of inpatients with COVID-19 |
| description |
Abstract Coronavirus disease 2019 (COVID-19) can present with a variety of symptoms. Severity of the disease may be associated with several factors. Here, we review clinical features of COVID-19 inpatients with different severities. This cross-sectional study was performed in Imam Reza hospital, Mashhad, Iran, during February–April 2020. COVID-19 patients with typical computed tomography (CT) patterns and/or positive reverse-transcriptase polymerase chain reaction (RT-PCR) were included. The patients were classified into three groups of moderate, severe, and critical based on disease severity. Demographic, clinical, laboratory, and radiologic findings were collected and compared. P < 0.05 was considered statistically significant. Overall, 200 patients with mean age of 69.75 ± 6.39 years, of whom 82 (41%) were female were studied. Disease was severe/critical in the majority of patients (167, 83.5%). Disease severity was significantly associated with age, malignant comorbidities, dyspnea, nausea/vomiting, confusion, respiratory rate, pulse rate, O2 saturation, extent of CT involvement, serum C-reactive protein (CRP), pH, pO2, and aspartate transaminase (P < 0.05). Moreover, complications including shock, coagulopathy, acidosis, sepsis, acute respiratory distress syndrome (ARDS), intensive care unit (ICU) admission, and intubation were significantly higher in patients with higher severities (P < 0.05). O2 saturation, nausea/vomiting, and extent of lung CT involvement were independent predictors of severe/critical COVID-19 (OR 0.342, 45.93, and 25.48, respectively; P < 0.05). Our results indicate O2 saturation, nausea/vomiting, and extent of lung CT involvement as independent predictors of severe COVID-19 conditions. Serum CRP levels and pO2 were also considerably higher patients with higher severity and can be used along with other factors to predict severe disease in COVID-19 patients. |
| format |
article |
| author |
Shima Nabavi Zahra Javidarabshahi Abolghasem Allahyari Mohammad Ramezani Mohsen Seddigh-Shamsi Sahar Ravanshad Mina AkbariRad Farnoosh Ebrahimzadeh Shohre Khatami Maryam Emadzadeh Neda Saeedian Ahmadreza Zarifian Maryam Miri Fariba Rezaeetalab Sepide Hejazi Reza Basiri Mahnaz Mozdourian |
| author_facet |
Shima Nabavi Zahra Javidarabshahi Abolghasem Allahyari Mohammad Ramezani Mohsen Seddigh-Shamsi Sahar Ravanshad Mina AkbariRad Farnoosh Ebrahimzadeh Shohre Khatami Maryam Emadzadeh Neda Saeedian Ahmadreza Zarifian Maryam Miri Fariba Rezaeetalab Sepide Hejazi Reza Basiri Mahnaz Mozdourian |
| author_sort |
Shima Nabavi |
| title |
Clinical features and disease severity in an Iranian population of inpatients with COVID-19 |
| title_short |
Clinical features and disease severity in an Iranian population of inpatients with COVID-19 |
| title_full |
Clinical features and disease severity in an Iranian population of inpatients with COVID-19 |
| title_fullStr |
Clinical features and disease severity in an Iranian population of inpatients with COVID-19 |
| title_full_unstemmed |
Clinical features and disease severity in an Iranian population of inpatients with COVID-19 |
| title_sort |
clinical features and disease severity in an iranian population of inpatients with covid-19 |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/d1905cf2744a407b992061fe7c9be45b |
| work_keys_str_mv |
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| _version_ |
1718383482275627008 |