Ultrafast sonochemical synthesis of protein-inorganic nanoflowers

Bhagwan S Batule,1 Ki Soo Park,1 Moon Il Kim,2 Hyun Gyu Park1 1Department of Chemical and Biomolecular Engineering (BK21+ Program), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 2Department of BioNano Technology, Gachon University, Seongnam, Republic of Korea Abstract: We de...

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Autores principales:	Batule BS, Park KS, Kim MI, Park HG
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d190abe9b9bf427a80c8e9cb5270597c
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spelling	oai:doaj.org-article:d190abe9b9bf427a80c8e9cb5270597c2021-12-02T02:28:07ZUltrafast sonochemical synthesis of protein-inorganic nanoflowers1178-2013https://doaj.org/article/d190abe9b9bf427a80c8e9cb5270597c2015-08-01T00:00:00Zhttp://www.dovepress.com/ultrafast-sonochemical-synthesis-of-protein-inorganic-nanoflowers-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Bhagwan S Batule,1 Ki Soo Park,1 Moon Il Kim,2 Hyun Gyu Park1 1Department of Chemical and Biomolecular Engineering (BK21+ Program), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 2Department of BioNano Technology, Gachon University, Seongnam, Republic of Korea Abstract: We developed a simple but efficient method to synthesize protein-inorganic hybrid nanostructures with a flower-like shape (nanoflowers), which relies on sonication to facilitate the synthesis of the nanoflowers. With this technique, we synthesized nanoflowers containing laccase as a model protein and copper phosphate within 5 minutes at room temperature. The resulting laccase nanoflowers yielded greatly enhanced activity, stability, and reusability, and their usefulness was successfully demonstrated by applying them in the colorimetric detection of epinephrine. The strategy developed could be used to rapidly synthesize nanoflowers for various applications in biosensor and enzyme catalysis and would expand the utilization of nanoflowers in diverse fields of biotechnology. Keywords: copper phosphate, laccase, epinephrine, hybrid nanomaterialsBatule BSPark KSKim MIPark HGDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss Special Issue on diverse applications in Nano-Theranostics, Pp 137-142 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Batule BS Park KS Kim MI Park HG Ultrafast sonochemical synthesis of protein-inorganic nanoflowers
description	Bhagwan S Batule,1 Ki Soo Park,1 Moon Il Kim,2 Hyun Gyu Park1 1Department of Chemical and Biomolecular Engineering (BK21+ Program), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 2Department of BioNano Technology, Gachon University, Seongnam, Republic of Korea Abstract: We developed a simple but efficient method to synthesize protein-inorganic hybrid nanostructures with a flower-like shape (nanoflowers), which relies on sonication to facilitate the synthesis of the nanoflowers. With this technique, we synthesized nanoflowers containing laccase as a model protein and copper phosphate within 5 minutes at room temperature. The resulting laccase nanoflowers yielded greatly enhanced activity, stability, and reusability, and their usefulness was successfully demonstrated by applying them in the colorimetric detection of epinephrine. The strategy developed could be used to rapidly synthesize nanoflowers for various applications in biosensor and enzyme catalysis and would expand the utilization of nanoflowers in diverse fields of biotechnology. Keywords: copper phosphate, laccase, epinephrine, hybrid nanomaterials
format	article
author	Batule BS Park KS Kim MI Park HG
author_facet	Batule BS Park KS Kim MI Park HG
author_sort	Batule BS
title	Ultrafast sonochemical synthesis of protein-inorganic nanoflowers
title_short	Ultrafast sonochemical synthesis of protein-inorganic nanoflowers
title_full	Ultrafast sonochemical synthesis of protein-inorganic nanoflowers
title_fullStr	Ultrafast sonochemical synthesis of protein-inorganic nanoflowers
title_full_unstemmed	Ultrafast sonochemical synthesis of protein-inorganic nanoflowers
title_sort	ultrafast sonochemical synthesis of protein-inorganic nanoflowers
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/d190abe9b9bf427a80c8e9cb5270597c
work_keys_str_mv	AT batulebs ultrafastsonochemicalsynthesisofproteininorganicnanoflowers AT parkks ultrafastsonochemicalsynthesisofproteininorganicnanoflowers AT kimmi ultrafastsonochemicalsynthesisofproteininorganicnanoflowers AT parkhg ultrafastsonochemicalsynthesisofproteininorganicnanoflowers
_version_	1718402496598114304

Ultrafast sonochemical synthesis of protein-inorganic nanoflowers

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