Imaging small molecule-induced endosomal escape of siRNA

Therapeutic siRNA becomes trapped in endosomes, limiting its efficacy. Here the authors use fluorescently-tagged galectin-9 as a biosensor for membrane damage to monitor endosomal escape of cholesterol-conjugated siRNA following treatment of small molecule membrane-destabilising drugs.

Guardado en:

Detalles Bibliográficos
Autores principales:	Hampus Du Rietz, Hampus Hedlund, Sten Wilhelmson, Pontus Nordenfelt, Anders Wittrup
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d19329c8d4634c19add07accb1157c0d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d19329c8d4634c19add07accb1157c0d
record_format	dspace
spelling	oai:doaj.org-article:d19329c8d4634c19add07accb1157c0d2021-12-02T14:42:49ZImaging small molecule-induced endosomal escape of siRNA10.1038/s41467-020-15300-12041-1723https://doaj.org/article/d19329c8d4634c19add07accb1157c0d2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15300-1https://doaj.org/toc/2041-1723Therapeutic siRNA becomes trapped in endosomes, limiting its efficacy. Here the authors use fluorescently-tagged galectin-9 as a biosensor for membrane damage to monitor endosomal escape of cholesterol-conjugated siRNA following treatment of small molecule membrane-destabilising drugs.Hampus Du RietzHampus HedlundSten WilhelmsonPontus NordenfeltAnders WittrupNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hampus Du Rietz Hampus Hedlund Sten Wilhelmson Pontus Nordenfelt Anders Wittrup Imaging small molecule-induced endosomal escape of siRNA
description	Therapeutic siRNA becomes trapped in endosomes, limiting its efficacy. Here the authors use fluorescently-tagged galectin-9 as a biosensor for membrane damage to monitor endosomal escape of cholesterol-conjugated siRNA following treatment of small molecule membrane-destabilising drugs.
format	article
author	Hampus Du Rietz Hampus Hedlund Sten Wilhelmson Pontus Nordenfelt Anders Wittrup
author_facet	Hampus Du Rietz Hampus Hedlund Sten Wilhelmson Pontus Nordenfelt Anders Wittrup
author_sort	Hampus Du Rietz
title	Imaging small molecule-induced endosomal escape of siRNA
title_short	Imaging small molecule-induced endosomal escape of siRNA
title_full	Imaging small molecule-induced endosomal escape of siRNA
title_fullStr	Imaging small molecule-induced endosomal escape of siRNA
title_full_unstemmed	Imaging small molecule-induced endosomal escape of siRNA
title_sort	imaging small molecule-induced endosomal escape of sirna
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d19329c8d4634c19add07accb1157c0d
work_keys_str_mv	AT hampusdurietz imagingsmallmoleculeinducedendosomalescapeofsirna AT hampushedlund imagingsmallmoleculeinducedendosomalescapeofsirna AT stenwilhelmson imagingsmallmoleculeinducedendosomalescapeofsirna AT pontusnordenfelt imagingsmallmoleculeinducedendosomalescapeofsirna AT anderswittrup imagingsmallmoleculeinducedendosomalescapeofsirna
_version_	1718389596168912896

Imaging small molecule-induced endosomal escape of siRNA

Ejemplares similares