Imaging small molecule-induced endosomal escape of siRNA

Imaging small molecule-induced endosomal escape of siRNA

Therapeutic siRNA becomes trapped in endosomes, limiting its efficacy. Here the authors use fluorescently-tagged galectin-9 as a biosensor for membrane damage to monitor endosomal escape of cholesterol-conjugated siRNA following treatment of small molecule membrane-destabilising drugs.

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Detalles Bibliográficos
Autores principales: Hampus Du Rietz, Hampus Hedlund, Sten Wilhelmson, Pontus Nordenfelt, Anders Wittrup
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/d19329c8d4634c19add07accb1157c0d
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