In vitro acellular dissolution of mineral fibres: A comparative study

Abstract The study of the mechanisms by which mineral fibres promote adverse effects in both animals and humans is a hot topic of multidisciplinary research with many aspects that still need to be elucidated. Besides length and diameter, a key parameter that determines the toxicity/pathogenicity of...

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Autores principales:	Alessandro F. Gualtieri, Simone Pollastri, Nicola Bursi Gandolfi, Magdalena Lassinantti Gualtieri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d194ebb1f38d4132ac075ad45f025ac6
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spelling	oai:doaj.org-article:d194ebb1f38d4132ac075ad45f025ac62021-12-02T16:07:51ZIn vitro acellular dissolution of mineral fibres: A comparative study10.1038/s41598-018-25531-42045-2322https://doaj.org/article/d194ebb1f38d4132ac075ad45f025ac62018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25531-4https://doaj.org/toc/2045-2322Abstract The study of the mechanisms by which mineral fibres promote adverse effects in both animals and humans is a hot topic of multidisciplinary research with many aspects that still need to be elucidated. Besides length and diameter, a key parameter that determines the toxicity/pathogenicity of a fibre is biopersistence, one component of which is biodurability. In this paper, biodurability of mineral fibres of social and economic importance (chrysotile, amphibole asbestos and fibrous erionite) has been determined for the first time in a systematic comparative way from in vitro acellular dissolution experiments. Dissolution was possible using the Gamble solution as simulated lung fluid (pH = 4 and at body temperature) so to reproduce the macrophage phagolysosome environment. The investigated mineral fibres display very different dissolution rates. For a 0.25 μm thick fibre, the calculated dissolution time of chrysotile is in the range 94–177 days, very short if compared to that of amphibole fibres (49–245 years), and fibrous erionite (181 years). Diffraction and SEM data on the dissolution products evidence that chrysotile rapidly undergoes amorphization with the formation of a nanophasic silica-rich fibrous metastable pseudomorph as first dissolution step whereas amphibole asbestos and fibrous erionite show minor signs of dissolution even after 9–12 months.Alessandro F. GualtieriSimone PollastriNicola Bursi GandolfiMagdalena Lassinantti GualtieriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alessandro F. Gualtieri Simone Pollastri Nicola Bursi Gandolfi Magdalena Lassinantti Gualtieri In vitro acellular dissolution of mineral fibres: A comparative study
description	Abstract The study of the mechanisms by which mineral fibres promote adverse effects in both animals and humans is a hot topic of multidisciplinary research with many aspects that still need to be elucidated. Besides length and diameter, a key parameter that determines the toxicity/pathogenicity of a fibre is biopersistence, one component of which is biodurability. In this paper, biodurability of mineral fibres of social and economic importance (chrysotile, amphibole asbestos and fibrous erionite) has been determined for the first time in a systematic comparative way from in vitro acellular dissolution experiments. Dissolution was possible using the Gamble solution as simulated lung fluid (pH = 4 and at body temperature) so to reproduce the macrophage phagolysosome environment. The investigated mineral fibres display very different dissolution rates. For a 0.25 μm thick fibre, the calculated dissolution time of chrysotile is in the range 94–177 days, very short if compared to that of amphibole fibres (49–245 years), and fibrous erionite (181 years). Diffraction and SEM data on the dissolution products evidence that chrysotile rapidly undergoes amorphization with the formation of a nanophasic silica-rich fibrous metastable pseudomorph as first dissolution step whereas amphibole asbestos and fibrous erionite show minor signs of dissolution even after 9–12 months.
format	article
author	Alessandro F. Gualtieri Simone Pollastri Nicola Bursi Gandolfi Magdalena Lassinantti Gualtieri
author_facet	Alessandro F. Gualtieri Simone Pollastri Nicola Bursi Gandolfi Magdalena Lassinantti Gualtieri
author_sort	Alessandro F. Gualtieri
title	In vitro acellular dissolution of mineral fibres: A comparative study
title_short	In vitro acellular dissolution of mineral fibres: A comparative study
title_full	In vitro acellular dissolution of mineral fibres: A comparative study
title_fullStr	In vitro acellular dissolution of mineral fibres: A comparative study
title_full_unstemmed	In vitro acellular dissolution of mineral fibres: A comparative study
title_sort	in vitro acellular dissolution of mineral fibres: a comparative study
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d194ebb1f38d4132ac075ad45f025ac6
work_keys_str_mv	AT alessandrofgualtieri invitroacellulardissolutionofmineralfibresacomparativestudy AT simonepollastri invitroacellulardissolutionofmineralfibresacomparativestudy AT nicolabursigandolfi invitroacellulardissolutionofmineralfibresacomparativestudy AT magdalenalassinanttigualtieri invitroacellulardissolutionofmineralfibresacomparativestudy
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In vitro acellular dissolution of mineral fibres: A comparative study

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