GSK-3β and BDNF genes may not be associated with venlafaxine treatment response in Chinese of Han ethnicity

GSK-3β and BDNF genes may not be associated with venlafaxine treatment response in Chinese of Han ethnicity

Qianqian Sun,1,2 Fan Yuan,1,2 Decheng Ren,1,2 Gaini Ma,1,2 Fengping Yang,1,3 Xi Wu,1,3 Lin He,1,3 Guang He1,21Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, P.R. China; 2Shangh...

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Autores principales: Sun Q, Yuan F, Ren D, Ma G, Yang F, Wu X, He L, He G
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2019
Materias:
association
GSK-3β
BDNF
major depressive disorder
venlafaxine
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/d195948a3ce54b9780ebba6aebd39af6
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spelling oai:doaj.org-article:d195948a3ce54b9780ebba6aebd39af62021-12-02T01:28:29ZGSK-3β and BDNF genes may not be associated with venlafaxine treatment response in Chinese of Han ethnicity1178-2021https://doaj.org/article/d195948a3ce54b9780ebba6aebd39af62019-03-01T00:00:00Zhttps://www.dovepress.com/gsk-3beta-and-bdnf-genes-may-not-be-associated-with-venlafaxine-treatm-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Qianqian Sun,1,2 Fan Yuan,1,2 Decheng Ren,1,2 Gaini Ma,1,2 Fengping Yang,1,3 Xi Wu,1,3 Lin He,1,3 Guang He1,21Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, P.R. China; 2Shanghai Key Laboratory of Psychotic Disorders, Shanghai Institute of Mental Health, Shanghai Jiao Tong University, Shanghai 200030, P.R. China; 3Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, P.R. ChinaPurpose: Venlafaxine is one of the commonly prescribed antidepressants for major depressive disorder (MDD). Accumulated evidence revealed the involvement of glutamatergic system in the pathophysiology of MDD and antidepressant treatment. Methods: We recruited 193 MDD patients who have been taking venlafaxine for 6 weeks, and investigated whether single nucleotide polymorphisms (SNPs) in GSK-3β and BDNF were associated with treatment response. Nine SNPs were selected randomly depending on association studies. Efficacy of treatment was determined by 17-item Hamilton Rating Scale. Allele and genotype frequencies were compared between responders and nonresponders.Results: After adjusting the false discovery rate, no significant difference was observed between response and nonresponse groups in allele or genotype distributions after venlafaxine treatment for 6 weeks.Conclusion: Our results indicated that genetic variants in the GSK-3β and BDNF may not be associated with treatment response in MDD patients treated with venlafaxine.Keywords: association, GSK-3β, BDNF, major depressive disorder, venlafaxineSun QYuan FRen DMa GYang FWu XHe LHe GDove Medical PressarticleassociationGSK-3βBDNFmajor depressive disordervenlafaxineNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 657-661 (2019)
institution DOAJ
collection DOAJ
language EN
topic association
GSK-3β
BDNF
major depressive disorder
venlafaxine
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle association
GSK-3β
BDNF
major depressive disorder
venlafaxine
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Sun Q
Yuan F
Ren D
Ma G
Yang F
Wu X
He L
He G
GSK-3β and BDNF genes may not be associated with venlafaxine treatment response in Chinese of Han ethnicity
description Qianqian Sun,1,2 Fan Yuan,1,2 Decheng Ren,1,2 Gaini Ma,1,2 Fengping Yang,1,3 Xi Wu,1,3 Lin He,1,3 Guang He1,21Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, P.R. China; 2Shanghai Key Laboratory of Psychotic Disorders, Shanghai Institute of Mental Health, Shanghai Jiao Tong University, Shanghai 200030, P.R. China; 3Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, P.R. ChinaPurpose: Venlafaxine is one of the commonly prescribed antidepressants for major depressive disorder (MDD). Accumulated evidence revealed the involvement of glutamatergic system in the pathophysiology of MDD and antidepressant treatment. Methods: We recruited 193 MDD patients who have been taking venlafaxine for 6 weeks, and investigated whether single nucleotide polymorphisms (SNPs) in GSK-3β and BDNF were associated with treatment response. Nine SNPs were selected randomly depending on association studies. Efficacy of treatment was determined by 17-item Hamilton Rating Scale. Allele and genotype frequencies were compared between responders and nonresponders.Results: After adjusting the false discovery rate, no significant difference was observed between response and nonresponse groups in allele or genotype distributions after venlafaxine treatment for 6 weeks.Conclusion: Our results indicated that genetic variants in the GSK-3β and BDNF may not be associated with treatment response in MDD patients treated with venlafaxine.Keywords: association, GSK-3β, BDNF, major depressive disorder, venlafaxine
format article
author Sun Q
Yuan F
Ren D
Ma G
Yang F
Wu X
He L
He G
author_facet Sun Q
Yuan F
Ren D
Ma G
Yang F
Wu X
He L
He G
author_sort Sun Q
title GSK-3β and BDNF genes may not be associated with venlafaxine treatment response in Chinese of Han ethnicity
title_short GSK-3β and BDNF genes may not be associated with venlafaxine treatment response in Chinese of Han ethnicity
title_full GSK-3β and BDNF genes may not be associated with venlafaxine treatment response in Chinese of Han ethnicity
title_fullStr GSK-3β and BDNF genes may not be associated with venlafaxine treatment response in Chinese of Han ethnicity
title_full_unstemmed GSK-3β and BDNF genes may not be associated with venlafaxine treatment response in Chinese of Han ethnicity
title_sort gsk-3β and bdnf genes may not be associated with venlafaxine treatment response in chinese of han ethnicity
publisher Dove Medical Press
publishDate 2019
url https://doaj.org/article/d195948a3ce54b9780ebba6aebd39af6
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