The catechol-O-methyltransferase (COMT) val158met polymorphism affects brain responses to repeated painful stimuli.

Despite the explosion of interest in the genetic underpinnings of individual differences in pain sensitivity, conflicting findings have emerged for most of the identified "pain genes". Perhaps the prime example of this inconsistency is represented by catechol-O-methyltransferase (COMT), as...

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Autores principales:	Marco L Loggia, Karin Jensen, Randy L Gollub, Ajay D Wasan, Robert R Edwards, Jian Kong
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d195ede7f3d34aee9341afd2b911a417
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spelling	oai:doaj.org-article:d195ede7f3d34aee9341afd2b911a4172021-11-18T07:33:48ZThe catechol-O-methyltransferase (COMT) val158met polymorphism affects brain responses to repeated painful stimuli.1932-620310.1371/journal.pone.0027764https://doaj.org/article/d195ede7f3d34aee9341afd2b911a4172011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22132136/?tool=EBIhttps://doaj.org/toc/1932-6203Despite the explosion of interest in the genetic underpinnings of individual differences in pain sensitivity, conflicting findings have emerged for most of the identified "pain genes". Perhaps the prime example of this inconsistency is represented by catechol-O-methyltransferase (COMT), as its substantial association to pain sensitivity has been reported in various studies, but rejected in several others. In line with findings from behavioral studies, we hypothesized that the effect of COMT on pain processing would become apparent only when the pain system was adequately challenged (i.e., after repeated pain stimulation). In the present study, we used functional Magnetic Resonance Imaging (fMRI) to investigate the brain response to heat pain stimuli in 54 subjects genotyped for the common COMT val158met polymorphism (val/val = n 22, val/met = n 20, met/met = n 12). Met/met subjects exhibited stronger pain-related fMRI signals than val/val in several brain structures, including the periaqueductal gray matter, lingual gyrus, cerebellum, hippocampal formation and precuneus. These effects were observed only for high intensity pain stimuli after repeated administration. In spite of our relatively small sample size, our results suggest that COMT appears to affect pain processing. Our data demonstrate that the effect of COMT on pain processing can be detected in presence of 1) a sufficiently robust challenge to the pain system to detect a genotype effect, and/or 2) the recruitment of pain-dampening compensatory mechanisms by the putatively more pain sensitive met homozygotes. These findings may help explain the inconsistencies in reported findings of the impact of COMT in pain regulation.Marco L LoggiaKarin JensenRandy L GollubAjay D WasanRobert R EdwardsJian KongPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 11, p e27764 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marco L Loggia Karin Jensen Randy L Gollub Ajay D Wasan Robert R Edwards Jian Kong The catechol-O-methyltransferase (COMT) val158met polymorphism affects brain responses to repeated painful stimuli.
description	Despite the explosion of interest in the genetic underpinnings of individual differences in pain sensitivity, conflicting findings have emerged for most of the identified "pain genes". Perhaps the prime example of this inconsistency is represented by catechol-O-methyltransferase (COMT), as its substantial association to pain sensitivity has been reported in various studies, but rejected in several others. In line with findings from behavioral studies, we hypothesized that the effect of COMT on pain processing would become apparent only when the pain system was adequately challenged (i.e., after repeated pain stimulation). In the present study, we used functional Magnetic Resonance Imaging (fMRI) to investigate the brain response to heat pain stimuli in 54 subjects genotyped for the common COMT val158met polymorphism (val/val = n 22, val/met = n 20, met/met = n 12). Met/met subjects exhibited stronger pain-related fMRI signals than val/val in several brain structures, including the periaqueductal gray matter, lingual gyrus, cerebellum, hippocampal formation and precuneus. These effects were observed only for high intensity pain stimuli after repeated administration. In spite of our relatively small sample size, our results suggest that COMT appears to affect pain processing. Our data demonstrate that the effect of COMT on pain processing can be detected in presence of 1) a sufficiently robust challenge to the pain system to detect a genotype effect, and/or 2) the recruitment of pain-dampening compensatory mechanisms by the putatively more pain sensitive met homozygotes. These findings may help explain the inconsistencies in reported findings of the impact of COMT in pain regulation.
format	article
author	Marco L Loggia Karin Jensen Randy L Gollub Ajay D Wasan Robert R Edwards Jian Kong
author_facet	Marco L Loggia Karin Jensen Randy L Gollub Ajay D Wasan Robert R Edwards Jian Kong
author_sort	Marco L Loggia
title	The catechol-O-methyltransferase (COMT) val158met polymorphism affects brain responses to repeated painful stimuli.
title_short	The catechol-O-methyltransferase (COMT) val158met polymorphism affects brain responses to repeated painful stimuli.
title_full	The catechol-O-methyltransferase (COMT) val158met polymorphism affects brain responses to repeated painful stimuli.
title_fullStr	The catechol-O-methyltransferase (COMT) val158met polymorphism affects brain responses to repeated painful stimuli.
title_full_unstemmed	The catechol-O-methyltransferase (COMT) val158met polymorphism affects brain responses to repeated painful stimuli.
title_sort	catechol-o-methyltransferase (comt) val158met polymorphism affects brain responses to repeated painful stimuli.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/d195ede7f3d34aee9341afd2b911a417
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The catechol-O-methyltransferase (COMT) val158met polymorphism affects brain responses to repeated painful stimuli.

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