Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer
Human metaplastic breast cancers (MpBC) are a rare, aggressive subclass of triple-negative breast cancers. Here, the authors show over-expression of histone reader TRIM24 is sufficient to generate tumors with a molecular signature of metabolic dysfunction and EMT in a mouse model of human MpBC.
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Nature Portfolio
2021
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oai:doaj.org-article:d198e1ab2b18460f8fd9661445a6e3922021-12-02T19:12:25ZMammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer10.1038/s41467-021-25650-z2041-1723https://doaj.org/article/d198e1ab2b18460f8fd9661445a6e3922021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25650-zhttps://doaj.org/toc/2041-1723Human metaplastic breast cancers (MpBC) are a rare, aggressive subclass of triple-negative breast cancers. Here, the authors show over-expression of histone reader TRIM24 is sufficient to generate tumors with a molecular signature of metabolic dysfunction and EMT in a mouse model of human MpBC.Vrutant V. ShahAundrietta D. DuncanShiming JiangSabrina A. StrattonKendra L. AlltonClinton YamAbhinav JainPatrick M. KrauseYue LuShirong CaiYizheng TuXinhui ZhouXiaomei ZhangYan JiangChristopher L. CarrollZhijun KangBin LiuJianjun ShenMihai GageaSebastian M. ManuLei HuoMichael GilcreaseReid T. PowellLei GuoClifford StephanPeter J. DaviesJan Parker-ThornburgGuillermina LozanoRichard R. BehringerHelen Piwnica-WormsJeffrey T. ChangStacy L. MoulderMichelle Craig BartonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021) |
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Science Q Vrutant V. Shah Aundrietta D. Duncan Shiming Jiang Sabrina A. Stratton Kendra L. Allton Clinton Yam Abhinav Jain Patrick M. Krause Yue Lu Shirong Cai Yizheng Tu Xinhui Zhou Xiaomei Zhang Yan Jiang Christopher L. Carroll Zhijun Kang Bin Liu Jianjun Shen Mihai Gagea Sebastian M. Manu Lei Huo Michael Gilcrease Reid T. Powell Lei Guo Clifford Stephan Peter J. Davies Jan Parker-Thornburg Guillermina Lozano Richard R. Behringer Helen Piwnica-Worms Jeffrey T. Chang Stacy L. Moulder Michelle Craig Barton Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer |
| description |
Human metaplastic breast cancers (MpBC) are a rare, aggressive subclass of triple-negative breast cancers. Here, the authors show over-expression of histone reader TRIM24 is sufficient to generate tumors with a molecular signature of metabolic dysfunction and EMT in a mouse model of human MpBC. |
| format |
article |
| author |
Vrutant V. Shah Aundrietta D. Duncan Shiming Jiang Sabrina A. Stratton Kendra L. Allton Clinton Yam Abhinav Jain Patrick M. Krause Yue Lu Shirong Cai Yizheng Tu Xinhui Zhou Xiaomei Zhang Yan Jiang Christopher L. Carroll Zhijun Kang Bin Liu Jianjun Shen Mihai Gagea Sebastian M. Manu Lei Huo Michael Gilcrease Reid T. Powell Lei Guo Clifford Stephan Peter J. Davies Jan Parker-Thornburg Guillermina Lozano Richard R. Behringer Helen Piwnica-Worms Jeffrey T. Chang Stacy L. Moulder Michelle Craig Barton |
| author_facet |
Vrutant V. Shah Aundrietta D. Duncan Shiming Jiang Sabrina A. Stratton Kendra L. Allton Clinton Yam Abhinav Jain Patrick M. Krause Yue Lu Shirong Cai Yizheng Tu Xinhui Zhou Xiaomei Zhang Yan Jiang Christopher L. Carroll Zhijun Kang Bin Liu Jianjun Shen Mihai Gagea Sebastian M. Manu Lei Huo Michael Gilcrease Reid T. Powell Lei Guo Clifford Stephan Peter J. Davies Jan Parker-Thornburg Guillermina Lozano Richard R. Behringer Helen Piwnica-Worms Jeffrey T. Chang Stacy L. Moulder Michelle Craig Barton |
| author_sort |
Vrutant V. Shah |
| title |
Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer |
| title_short |
Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer |
| title_full |
Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer |
| title_fullStr |
Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer |
| title_full_unstemmed |
Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer |
| title_sort |
mammary-specific expression of trim24 establishes a mouse model of human metaplastic breast cancer |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/d198e1ab2b18460f8fd9661445a6e392 |
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