Carnosic Acid Induces Antiproliferation and Anti-Metastatic Property of Esophageal Cancer Cells via MAPK Signaling Pathways

Background. Carnosic acid (CA) is a polyphenolic diterpene extracted from rosemary. Reports have shown that CA possesses anticancer activity. However, whether CA inhibits esophageal squamous cell carcinoma, an aggressive type of esophageal cancer, remains untested. Methods. The effects of CA on cell...

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Autores principales:	Sicong Jiang, Yinda Qiu, Zhaozhen Wang, Yulong Ji, Xiaofang Zhang, Xiaosong Yan, Zhiqiang Zhan
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/d1a12b6a2fc440debf8d51e43837ebaf
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spelling	oai:doaj.org-article:d1a12b6a2fc440debf8d51e43837ebaf2021-11-29T00:56:40ZCarnosic Acid Induces Antiproliferation and Anti-Metastatic Property of Esophageal Cancer Cells via MAPK Signaling Pathways1687-846910.1155/2021/4451533https://doaj.org/article/d1a12b6a2fc440debf8d51e43837ebaf2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/4451533https://doaj.org/toc/1687-8469Background. Carnosic acid (CA) is a polyphenolic diterpene extracted from rosemary. Reports have shown that CA possesses anticancer activity. However, whether CA inhibits esophageal squamous cell carcinoma, an aggressive type of esophageal cancer, remains untested. Methods. The effects of CA on cell survival, migration, and apoptosis were evaluated by a combination of MTT, colony formation assay, flow cytometry, and Transwell assay. The potential signaling pathways involved were investigated via Western blot assay. Results. CA dose-dependently inhibited cell proliferation, apoptosis, migration, and colony formation. Mechanistically, CA arrested the cell cycle at G2/M phase, promoted cell apoptosis, induced DNA damage, and inhibited the MAPK signaling pathways. Conclusion. Our results suggest that CA is a potential anticancer drug for esophageal squamous cell carcinoma.Sicong JiangYinda QiuZhaozhen WangYulong JiXiaofang ZhangXiaosong YanZhiqiang ZhanHindawi LimitedarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENJournal of Oncology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Sicong Jiang Yinda Qiu Zhaozhen Wang Yulong Ji Xiaofang Zhang Xiaosong Yan Zhiqiang Zhan Carnosic Acid Induces Antiproliferation and Anti-Metastatic Property of Esophageal Cancer Cells via MAPK Signaling Pathways
description	Background. Carnosic acid (CA) is a polyphenolic diterpene extracted from rosemary. Reports have shown that CA possesses anticancer activity. However, whether CA inhibits esophageal squamous cell carcinoma, an aggressive type of esophageal cancer, remains untested. Methods. The effects of CA on cell survival, migration, and apoptosis were evaluated by a combination of MTT, colony formation assay, flow cytometry, and Transwell assay. The potential signaling pathways involved were investigated via Western blot assay. Results. CA dose-dependently inhibited cell proliferation, apoptosis, migration, and colony formation. Mechanistically, CA arrested the cell cycle at G2/M phase, promoted cell apoptosis, induced DNA damage, and inhibited the MAPK signaling pathways. Conclusion. Our results suggest that CA is a potential anticancer drug for esophageal squamous cell carcinoma.
format	article
author	Sicong Jiang Yinda Qiu Zhaozhen Wang Yulong Ji Xiaofang Zhang Xiaosong Yan Zhiqiang Zhan
author_facet	Sicong Jiang Yinda Qiu Zhaozhen Wang Yulong Ji Xiaofang Zhang Xiaosong Yan Zhiqiang Zhan
author_sort	Sicong Jiang
title	Carnosic Acid Induces Antiproliferation and Anti-Metastatic Property of Esophageal Cancer Cells via MAPK Signaling Pathways
title_short	Carnosic Acid Induces Antiproliferation and Anti-Metastatic Property of Esophageal Cancer Cells via MAPK Signaling Pathways
title_full	Carnosic Acid Induces Antiproliferation and Anti-Metastatic Property of Esophageal Cancer Cells via MAPK Signaling Pathways
title_fullStr	Carnosic Acid Induces Antiproliferation and Anti-Metastatic Property of Esophageal Cancer Cells via MAPK Signaling Pathways
title_full_unstemmed	Carnosic Acid Induces Antiproliferation and Anti-Metastatic Property of Esophageal Cancer Cells via MAPK Signaling Pathways
title_sort	carnosic acid induces antiproliferation and anti-metastatic property of esophageal cancer cells via mapk signaling pathways
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/d1a12b6a2fc440debf8d51e43837ebaf
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Carnosic Acid Induces Antiproliferation and Anti-Metastatic Property of Esophageal Cancer Cells via MAPK Signaling Pathways

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