Determination of role of type 16 human papillomavirus and risk factors in assessing oropharyngeal cancer survival

Background: It is ascertained that the survival rate of patients infected with type 16 human papillomavirus (HPV16) positive is better as compared to those infected with HPV16 negative. The present study was conducted to determine rgw role of HPV16 and risk factors in assessing oropharyngeal cancer...

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Autores principales:	Meenakshi Bhasin, Harkanwal Preet Singh, Padam Singh, Rachna Dhingra, Saniya Arora Kohli, Anurag Azad
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	oropharyngeal cancer smoking tobacco type 16 human papillomavirus Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
Acceso en línea:	https://doaj.org/article/d1a4df415ab141a2aa876c4ee35161eb
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spelling	oai:doaj.org-article:d1a4df415ab141a2aa876c4ee35161eb2021-11-19T12:15:52ZDetermination of role of type 16 human papillomavirus and risk factors in assessing oropharyngeal cancer survival0975-740610.4103/jpbs.jpbs_132_21https://doaj.org/article/d1a4df415ab141a2aa876c4ee35161eb2021-01-01T00:00:00Zhttp://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=6;spage=1300;epage=1302;aulast=Bhasinhttps://doaj.org/toc/0975-7406Background: It is ascertained that the survival rate of patients infected with type 16 human papillomavirus (HPV16) positive is better as compared to those infected with HPV16 negative. The present study was conducted to determine rgw role of HPV16 and risk factors in assessing oropharyngeal cancer (OPC) death. Methodology: A total of 102 clinically and histologically proven cases of oral pharyngeal cancer were included. Seropositivity for HPV16 E6 as a marker of HPV16-positive cancer was estimated. Results: Out of 102 patients, there were 70 males and 32 females. Significant risk factors associated with OPC survival overall in the univariate analysis was female sex (hazard ratio [HR] 0.54, 95% confidence level [CL]: 0.36–80), alcohol use >2 drinks/day (HR 1.54, 95% CL: 1.12–2.08), smoking >10 pack-years (HR 2.20, 95% CL: 1.42–3.58), moderate dental (HR 1.54, 95% CL: 1.02–2.32), underweight (HR 2.24, 95% CL: 1.34–3.60), and Stage IV cancer (HR 2.82, 95% CL: 1.76–4.40). There was significant low risk for death among HPV16 positive (HR 0.48, 95% CL: 0.32–0.70). Conclusion: HPV16 status is an independent prognostic factor for OPC deaths. The common risk factors were female gender, moderate oral care, underweight body mass index, excessive alcohol, and smoking tobacco.Meenakshi BhasinHarkanwal Preet SinghPadam SinghRachna DhingraSaniya Arora KohliAnurag AzadWolters Kluwer Medknow Publicationsarticleoropharyngeal cancersmoking tobaccotype 16 human papillomavirusPharmacy and materia medicaRS1-441Analytical chemistryQD71-142ENJournal of Pharmacy and Bioallied Sciences, Vol 13, Iss 6, Pp 1300-1302 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oropharyngeal cancer smoking tobacco type 16 human papillomavirus Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
spellingShingle	oropharyngeal cancer smoking tobacco type 16 human papillomavirus Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142 Meenakshi Bhasin Harkanwal Preet Singh Padam Singh Rachna Dhingra Saniya Arora Kohli Anurag Azad Determination of role of type 16 human papillomavirus and risk factors in assessing oropharyngeal cancer survival
description	Background: It is ascertained that the survival rate of patients infected with type 16 human papillomavirus (HPV16) positive is better as compared to those infected with HPV16 negative. The present study was conducted to determine rgw role of HPV16 and risk factors in assessing oropharyngeal cancer (OPC) death. Methodology: A total of 102 clinically and histologically proven cases of oral pharyngeal cancer were included. Seropositivity for HPV16 E6 as a marker of HPV16-positive cancer was estimated. Results: Out of 102 patients, there were 70 males and 32 females. Significant risk factors associated with OPC survival overall in the univariate analysis was female sex (hazard ratio [HR] 0.54, 95% confidence level [CL]: 0.36–80), alcohol use >2 drinks/day (HR 1.54, 95% CL: 1.12–2.08), smoking >10 pack-years (HR 2.20, 95% CL: 1.42–3.58), moderate dental (HR 1.54, 95% CL: 1.02–2.32), underweight (HR 2.24, 95% CL: 1.34–3.60), and Stage IV cancer (HR 2.82, 95% CL: 1.76–4.40). There was significant low risk for death among HPV16 positive (HR 0.48, 95% CL: 0.32–0.70). Conclusion: HPV16 status is an independent prognostic factor for OPC deaths. The common risk factors were female gender, moderate oral care, underweight body mass index, excessive alcohol, and smoking tobacco.
format	article
author	Meenakshi Bhasin Harkanwal Preet Singh Padam Singh Rachna Dhingra Saniya Arora Kohli Anurag Azad
author_facet	Meenakshi Bhasin Harkanwal Preet Singh Padam Singh Rachna Dhingra Saniya Arora Kohli Anurag Azad
author_sort	Meenakshi Bhasin
title	Determination of role of type 16 human papillomavirus and risk factors in assessing oropharyngeal cancer survival
title_short	Determination of role of type 16 human papillomavirus and risk factors in assessing oropharyngeal cancer survival
title_full	Determination of role of type 16 human papillomavirus and risk factors in assessing oropharyngeal cancer survival
title_fullStr	Determination of role of type 16 human papillomavirus and risk factors in assessing oropharyngeal cancer survival
title_full_unstemmed	Determination of role of type 16 human papillomavirus and risk factors in assessing oropharyngeal cancer survival
title_sort	determination of role of type 16 human papillomavirus and risk factors in assessing oropharyngeal cancer survival
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/d1a4df415ab141a2aa876c4ee35161eb
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Determination of role of type 16 human papillomavirus and risk factors in assessing oropharyngeal cancer survival

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