Tumor necrosis factor-α and its role as a mediator in myocardial infarction: A brief review
Tumor necrosis factor-α (TNF-α) contributes to myocardial infarction (MI) injury. Polymorphism of TNF-α gene promoter region and secretion and release of TNF-α and its transformation by a series of signaling pathways are all changed at different points of pathophysiological process in MI. Resear...
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KeAi Communications Co., Ltd.
2015
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oai:doaj.org-article:d1a5e03828c9430e933319f80351f3cb2021-12-02T13:26:49ZTumor necrosis factor-α and its role as a mediator in myocardial infarction: A brief review2095-882X10.1016/j.cdtm.2015.02.002https://doaj.org/article/d1a5e03828c9430e933319f80351f3cb2015-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X15000031https://doaj.org/toc/2095-882XTumor necrosis factor-α (TNF-α) contributes to myocardial infarction (MI) injury. Polymorphism of TNF-α gene promoter region and secretion and release of TNF-α and its transformation by a series of signaling pathways are all changed at different points of pathophysiological process in MI. Researches also investigated TNF-α antagonists and their potential therapeutic role in the setting of MI and heart failure at both molecular and clinical level. This article briefly reviews TNF-α and its mechanism as a mediator in MI. Keywords: Tumor necrosis factor-α, Myocardial infarction, Heart failureMing TianYun-Chuan YuanJia-Yi LiMichael R. GionfriddoRong-Chong HuangKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 1, Iss 1, Pp 18-26 (2015) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Medicine (General) R5-920 |
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Medicine (General) R5-920 Ming Tian Yun-Chuan Yuan Jia-Yi Li Michael R. Gionfriddo Rong-Chong Huang Tumor necrosis factor-α and its role as a mediator in myocardial infarction: A brief review |
| description |
Tumor necrosis factor-α (TNF-α) contributes to myocardial infarction (MI) injury. Polymorphism of TNF-α gene promoter region and secretion and release of TNF-α and its transformation by a series of signaling pathways are all changed at different points of pathophysiological process in MI. Researches also investigated TNF-α antagonists and their potential therapeutic role in the setting of MI and heart failure at both molecular and clinical level. This article briefly reviews TNF-α and its mechanism as a mediator in MI. Keywords: Tumor necrosis factor-α, Myocardial infarction, Heart failure |
| format |
article |
| author |
Ming Tian Yun-Chuan Yuan Jia-Yi Li Michael R. Gionfriddo Rong-Chong Huang |
| author_facet |
Ming Tian Yun-Chuan Yuan Jia-Yi Li Michael R. Gionfriddo Rong-Chong Huang |
| author_sort |
Ming Tian |
| title |
Tumor necrosis factor-α and its role as a mediator in myocardial infarction: A brief review |
| title_short |
Tumor necrosis factor-α and its role as a mediator in myocardial infarction: A brief review |
| title_full |
Tumor necrosis factor-α and its role as a mediator in myocardial infarction: A brief review |
| title_fullStr |
Tumor necrosis factor-α and its role as a mediator in myocardial infarction: A brief review |
| title_full_unstemmed |
Tumor necrosis factor-α and its role as a mediator in myocardial infarction: A brief review |
| title_sort |
tumor necrosis factor-î± and its role as a mediator in myocardial infarction: a brief review |
| publisher |
KeAi Communications Co., Ltd. |
| publishDate |
2015 |
| url |
https://doaj.org/article/d1a5e03828c9430e933319f80351f3cb |
| work_keys_str_mv |
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| _version_ |
1718393060363075584 |