Positive surface charge of GluN1 N-terminus mediates the direct interaction with EphB2 and NMDAR mobility

NMDA receptors undergo constant cycling into and out of the postsynaptic density. Here authors show that NMDAR's GluN1 subunit is required to maintain NMDARs at dendritic spine synapses by direct extracellular interaction with the receptor tyrosine kinase EphB2.

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Autores principales:	Halley R. Washburn, Nan L. Xia, Wei Zhou, Yu-Ting Mao, Matthew B. Dalva
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d1ad9e82cb6f41d89b33d67ab652a1ef
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spelling	oai:doaj.org-article:d1ad9e82cb6f41d89b33d67ab652a1ef2021-12-02T16:50:04ZPositive surface charge of GluN1 N-terminus mediates the direct interaction with EphB2 and NMDAR mobility10.1038/s41467-020-14345-62041-1723https://doaj.org/article/d1ad9e82cb6f41d89b33d67ab652a1ef2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14345-6https://doaj.org/toc/2041-1723NMDA receptors undergo constant cycling into and out of the postsynaptic density. Here authors show that NMDAR's GluN1 subunit is required to maintain NMDARs at dendritic spine synapses by direct extracellular interaction with the receptor tyrosine kinase EphB2.Halley R. WashburnNan L. XiaWei ZhouYu-Ting MaoMatthew B. DalvaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Halley R. Washburn Nan L. Xia Wei Zhou Yu-Ting Mao Matthew B. Dalva Positive surface charge of GluN1 N-terminus mediates the direct interaction with EphB2 and NMDAR mobility
description	NMDA receptors undergo constant cycling into and out of the postsynaptic density. Here authors show that NMDAR's GluN1 subunit is required to maintain NMDARs at dendritic spine synapses by direct extracellular interaction with the receptor tyrosine kinase EphB2.
format	article
author	Halley R. Washburn Nan L. Xia Wei Zhou Yu-Ting Mao Matthew B. Dalva
author_facet	Halley R. Washburn Nan L. Xia Wei Zhou Yu-Ting Mao Matthew B. Dalva
author_sort	Halley R. Washburn
title	Positive surface charge of GluN1 N-terminus mediates the direct interaction with EphB2 and NMDAR mobility
title_short	Positive surface charge of GluN1 N-terminus mediates the direct interaction with EphB2 and NMDAR mobility
title_full	Positive surface charge of GluN1 N-terminus mediates the direct interaction with EphB2 and NMDAR mobility
title_fullStr	Positive surface charge of GluN1 N-terminus mediates the direct interaction with EphB2 and NMDAR mobility
title_full_unstemmed	Positive surface charge of GluN1 N-terminus mediates the direct interaction with EphB2 and NMDAR mobility
title_sort	positive surface charge of glun1 n-terminus mediates the direct interaction with ephb2 and nmdar mobility
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d1ad9e82cb6f41d89b33d67ab652a1ef
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Positive surface charge of GluN1 N-terminus mediates the direct interaction with EphB2 and NMDAR mobility

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