Possible association between SIRT1 single nucleotide polymorphisms and predisposition to antisocial personality traits in Chinese adolescents

Abstract Accumulating evidence suggests an association between the SIRT1 gene and human psychiatric disorders. The aim of the study was to investigate the association between SIRT1 and predisposition to antisocial personality traits (ASP) in Chinese adolescents. Participants consisted of 327 control...

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Autores principales:	Hongjuan Chang, Qiuge Yan, Jie Tang, Juan Huang, Yanmei Zhang, Yuqiao Ma, Xiaozhou Ye, Lina Tang, Linguo Wu, Chunxia Wu, Yizhen Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d1af2ec2e0c249b0a910d9a66ea7c8dc
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spelling	oai:doaj.org-article:d1af2ec2e0c249b0a910d9a66ea7c8dc2021-12-02T11:52:31ZPossible association between SIRT1 single nucleotide polymorphisms and predisposition to antisocial personality traits in Chinese adolescents10.1038/s41598-017-01208-22045-2322https://doaj.org/article/d1af2ec2e0c249b0a910d9a66ea7c8dc2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01208-2https://doaj.org/toc/2045-2322Abstract Accumulating evidence suggests an association between the SIRT1 gene and human psychiatric disorders. The aim of the study was to investigate the association between SIRT1 and predisposition to antisocial personality traits (ASP) in Chinese adolescents. Participants consisted of 327 controls and 261 juvenile offenders who were diagnosed with predisposition to ASP according to the Personality Diagnostic Questionnaire. Four tag single nucleotide polymorphisms (tagSNPs) of SIRT1, namely rs12778366, rs7896005, rs10823112, and rs4746720, were genotyped. Association analysis between individual SNPs and ASP risk revealed the CC genotype of rs4746720 to be significantly associated with reduced risk of ASP (OR = 0.51, 95% CI = 0.33–0.77, adjusted P = 0.007). Haplotype analysis showed the TAAC haplotype was associated with reduced susceptibility to ASP (OR = 0.72, 95% CI = 0.57–0.91, P = 0.005). Moreover, rs4746720 variants were found to not only have a direct impact on ASP susceptibility but also modulate the effect of alcohol consumption (Y = 0.022X + 0.431 vs. Y = −0.066X + 0.387). The present study is the first to report a significant association between SIRT1 polymorphisms and ASP in adolescents. This finding is expected to aid in the development of effective interventions for this socially and personally costly disorder.Hongjuan ChangQiuge YanJie TangJuan HuangYanmei ZhangYuqiao MaXiaozhou YeLina TangLinguo WuChunxia WuYizhen YuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hongjuan Chang Qiuge Yan Jie Tang Juan Huang Yanmei Zhang Yuqiao Ma Xiaozhou Ye Lina Tang Linguo Wu Chunxia Wu Yizhen Yu Possible association between SIRT1 single nucleotide polymorphisms and predisposition to antisocial personality traits in Chinese adolescents
description	Abstract Accumulating evidence suggests an association between the SIRT1 gene and human psychiatric disorders. The aim of the study was to investigate the association between SIRT1 and predisposition to antisocial personality traits (ASP) in Chinese adolescents. Participants consisted of 327 controls and 261 juvenile offenders who were diagnosed with predisposition to ASP according to the Personality Diagnostic Questionnaire. Four tag single nucleotide polymorphisms (tagSNPs) of SIRT1, namely rs12778366, rs7896005, rs10823112, and rs4746720, were genotyped. Association analysis between individual SNPs and ASP risk revealed the CC genotype of rs4746720 to be significantly associated with reduced risk of ASP (OR = 0.51, 95% CI = 0.33–0.77, adjusted P = 0.007). Haplotype analysis showed the TAAC haplotype was associated with reduced susceptibility to ASP (OR = 0.72, 95% CI = 0.57–0.91, P = 0.005). Moreover, rs4746720 variants were found to not only have a direct impact on ASP susceptibility but also modulate the effect of alcohol consumption (Y = 0.022X + 0.431 vs. Y = −0.066X + 0.387). The present study is the first to report a significant association between SIRT1 polymorphisms and ASP in adolescents. This finding is expected to aid in the development of effective interventions for this socially and personally costly disorder.
format	article
author	Hongjuan Chang Qiuge Yan Jie Tang Juan Huang Yanmei Zhang Yuqiao Ma Xiaozhou Ye Lina Tang Linguo Wu Chunxia Wu Yizhen Yu
author_facet	Hongjuan Chang Qiuge Yan Jie Tang Juan Huang Yanmei Zhang Yuqiao Ma Xiaozhou Ye Lina Tang Linguo Wu Chunxia Wu Yizhen Yu
author_sort	Hongjuan Chang
title	Possible association between SIRT1 single nucleotide polymorphisms and predisposition to antisocial personality traits in Chinese adolescents
title_short	Possible association between SIRT1 single nucleotide polymorphisms and predisposition to antisocial personality traits in Chinese adolescents
title_full	Possible association between SIRT1 single nucleotide polymorphisms and predisposition to antisocial personality traits in Chinese adolescents
title_fullStr	Possible association between SIRT1 single nucleotide polymorphisms and predisposition to antisocial personality traits in Chinese adolescents
title_full_unstemmed	Possible association between SIRT1 single nucleotide polymorphisms and predisposition to antisocial personality traits in Chinese adolescents
title_sort	possible association between sirt1 single nucleotide polymorphisms and predisposition to antisocial personality traits in chinese adolescents
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d1af2ec2e0c249b0a910d9a66ea7c8dc
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Possible association between SIRT1 single nucleotide polymorphisms and predisposition to antisocial personality traits in Chinese adolescents

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